iPTMnet Report for P0CAP2 (POLR2M)
Protein Information
| UniProt AC / UniProt ID | P0CAP2 / GRL1A_HUMAN |
| Protein Name | DNA-directed RNA polymerase II subunit GRINL1A |
| Gene Name | Name: POLR2M Synonyms:GRINL1A; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P0CAP2 |
| PRO Name | DNA-directed RNA polymerase II subunit GRINL1A isoforms 1/2/3 (human) |
| Definition | A DNA-directed RNA polymerase II subunit GRINL1A (human), isoforms 1, 2, and 3. |
| Short Label | hPOLR2M/iso:[1/2/3] |
| Category | organism-seqgroup |
DAG ViewP0CAP2 (POLR2M) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K71 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S72 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K83 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S144 | Phosphorylation | score1 | PhosphoSitePlus | |||
| Y148 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T149 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S157 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S166 | O-Glycosylation | score1 | GlyGen | 30379171, 31492838 | ||
| S178 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S179 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T184 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S185 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S186 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S187 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S209 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S214 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T215 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S222 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S270 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K282 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K326 | Ubiquitination | score1 | PhosphoSitePlus | |||
| S364 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S365 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| S356 | Phosphorylation | score1 | PhosphoSitePlus |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K83 | M83 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] | |
| S179 | G179 | Biomuta | DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] | |
| S185 | F185 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
| S209 | * | Biomuta | DOID:1324 / lung cancer [ cosmic ] | |
| K216 | N216 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
| S222 | F222 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc ] |
