Protein Information

Cytoscape View


UniProt AC / UniProt ID P0C0S8 / H2A1_HUMAN
Protein Name Histone H2A type 1
Gene Name Name: HIST1H2AM
Synonyms:H2AFP;Synonyms:H2AFC;Synonyms:H2AFD;Synonyms:H2AFI;Synonyms:H2AFN;
Organism Homo sapiens (Human)

PRO ID PR:P0C0S8
DAG View
PRO Name histone H2A type 1-G/I/K/L/M (human)
Definition A histone H2A type 1-G/I/K/L/M that is encoded in the genome of human.
Short Label hHIST1H2A[G/I/K/L/M]
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P0C0S8 (HIST1H2AM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 15823041, 16457589, 11709551
S2 Phosphorylation O75582 (RPS6KA5) phospho.ELM   PRO   Signor   UniProt 15010469, 11709551
K6 Acetylation PRO 17709392
K10 Acetylation PRO 18552846, 12937907
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
S19 Phosphorylation PhosphoSitePlus
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Ubiquitination PRO   UniProt 18400894, 16359901, 15386022, ...25470042, 16702407
T121 Phosphorylation PR:O43683 (hBUB1) PRO   UniProt 19965387, 14667408, 11756469, ...24140421, 15078818


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044889 (hHIST1H2A[G/I/K/L/M]/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044890 (hHIST1H2A[G/I/K/L/M]/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000044891 (hHIST1H2A[G/I/K/L/M]/InitMet-/Phos:1) pS2 PRO 15010469
PR:000044893 (hHIST1H2A[G/I/K/L/M]/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000044898 (hHIST1H2A[G/I/K/L/M]/InitMet-/Phos:2) pT121 PR:O43683 (hBUB1) PRO 11756469, 14667408, 19965387


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 T2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S2 L2 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1612 / breast cancer [ tcga ]
S2 Y2 Biomuta DOID:5041 / esophageal cancer [ tcga ]
S2 F2 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ tcga ]
S2 C2 Biomuta DOID:3571 / liver cancer [ tcga ] DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ] DOID:11934 / head and neck cancer [ tcga ]
K6 N6 Biomuta DOID:11934 / head and neck cancer [ icgc, tcga ]
K6 R6 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K14 Q14 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K14 E14 Biomuta DOID:1324 / lung cancer [ tcga ]
K16 E16 Biomuta DOID:363 / uterine cancer [ tcga ]
K16 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S19 Y19 Biomuta DOID:1324 / lung cancer [ cosmic ]
S19 F19 Biomuta DOID:1324 / lung cancer [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S19 C19 Biomuta DOID:5041 / esophageal cancer [ icgc ]
Q105 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
Q105 P105 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Q105 R105 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ] DOID:263 / kidney cancer [ cosmic, tcga ]
Q105 H105 Biomuta DOID:3571 / liver cancer [ tcga ]
K119 Q119 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K119 T119 Biomuta DOID:363 / uterine cancer [ tcga ]
K120 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K120 N120 Biomuta DOID:1324 / lung cancer [ tcga ]
K120 E120 Biomuta DOID:10534 / stomach cancer [ cosmic ]