Protein Information

Cytoscape View


UniProt AC / UniProt ID P09960 / LKHA4_HUMAN
Protein Name Leukotriene A-4 hydrolase
Gene Name Name: LTA4H
Synonyms:LTA4;
Organism Homo sapiens (Human)

PRO ID PR:P09960
DAG View
PRO Name leukotriene A-4 hydrolase (human)
Definition A leukotriene A-4 hydrolase that is encoded in the genome of human.
Short Label hLTA4H
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09960 (LTA4H) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
S27 Phosphorylation PhosphoSitePlus
T34 Phosphorylation PhosphoSitePlus
T42 O-Glycosylation GlyGen 23301498, 16408927, 30397120, ...29351928, 32119511, 28510447
S45 O-Glycosylation GlyGen 23301498, 16408927, 30397120, ...29351928, 32119511, 28510447
K58 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K73 Acetylation PhosphoSitePlus   UniProt 19608861
K73 Ubiquitination PhosphoSitePlus
S81 Phosphorylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
C147 S-Nitrosylation dbSNO 26338901
K154 Ubiquitination PhosphoSitePlus
S172 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S212 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K337 Acetylation PhosphoSitePlus   UniProt 19608861
K337 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
K414 Acetylation PhosphoSitePlus   UniProt 19608861
K414 Ubiquitination PhosphoSitePlus
S416 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 9395533
Y417 Phosphorylation PhosphoSitePlus
K418 Acetylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
K434 Acetylation PhosphoSitePlus
K434 Ubiquitination PhosphoSitePlus
K480 Acetylation PhosphoSitePlus
K480 Ubiquitination PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
K573 Acetylation PhosphoSitePlus   UniProt 19608861
K573 Ubiquitination PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
T600 Phosphorylation PhosphoSitePlus
K606 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S172 Phosphorylation HPRD 20068231
S416 Phosphorylation HPRD 9395533
Y589 Phosphorylation HPRD 18767875
T600 Phosphorylation HPRD 18767875


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S45 Y45 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3571 / liver cancer [ icgc ]
S172 I172 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T238 N238 Biomuta DOID:3571 / liver cancer [ icgc ]
S416 Y416 Biomuta DOID:3571 / liver cancer [ icgc ]
K418 N418 Biomuta DOID:1612 / breast cancer [ cosmic ]
K566 R566 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]