iPTMnet Report for P09923 (ALPI)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P09923 / PPBI_HUMAN
Protein Name Intestinal-type alkaline phosphatase precursor
Gene Name Name: ALPI
Organism Homo sapiens (Human)

PRO ID PR:P09923
DAG View
PRO Name intestinal-type alkaline phosphatase (human)
Definition An intestinal alkaline phosphatase that is encoded in the genome of human.
Short Label hALPI
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09923 (ALPI) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K43 Ubiquitination PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S111 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17322306, 18767875, 15302935, ...20068231
S150 Phosphorylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
Y179 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
T270 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K43 N43 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K50 N50 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S150 F150 Biomuta DOID:4159 / skin cancer [ cosmic ]
S150 Y150 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K160 Q160 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S174 L174 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y179 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K250 E250 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T270 N270 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]