iPTMnet Report for P09917 (ALOX5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P09917 / LOX5_HUMAN
Protein Name Polyunsaturated fatty acid 5-lipoxygenase
Gene Name Name: ALOX5
Synonyms:LOG5;
Organism Homo sapiens (Human)

PRO ID PR:P09917
DAG View
PRO Name polyunsaturated fatty acid 5-lipoxygenase (human)
Definition A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of human.
Short Label hALOX5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09917 (ALOX5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y21 Phosphorylation PhosphoSitePlus
Y23 Phosphorylation PhosphoSitePlus
F42 Phosphorylation IntAct 24860872
Y43 Phosphorylation PhosphoSitePlus
S53 Phosphorylation IntAct 24860872
Y54 Phosphorylation PhosphoSitePlus
Y75 Phosphorylation PhosphoSitePlus
T87 Phosphorylation PhosphoSitePlus
D94 Phosphorylation IntAct 24860872
Y95 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
T105 Phosphorylation PhosphoSitePlus
Y182 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus
T259 Phosphorylation PhosphoSitePlus
T260 Phosphorylation PhosphoSitePlus
S266 Phosphorylation PhosphoSitePlus
L271 Phosphorylation IntAct 24860872
S272 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , Q9UQM7 (CAMK2A) , P17612 (PRKACA) , P49137 (MAPKAPK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 18978352, 12670876, 11844797, ...10779545
C301 Methylation IEDB 31844290
C311 Methylation IEDB 31844290
T445 Phosphorylation IntAct   PhosphoSitePlus 24860872
Y446 Phosphorylation PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
T486 Phosphorylation PhosphoSitePlus
S523 Phosphorylation IntAct   RLIMS-P 26210919, 24860872, 16230355, ...15280375
S524 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   UniProt 26210919, 16230355, 15280375
K528 Acetylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
S664 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   Signor 12205041, 12670876
S671 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S272 Phosphorylation P49137 (MAPKAPK2) HPRD 11844797, 10779545


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046325 (hALOX5/InitMet-/Phos:1) pS272 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y21 H21 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S53 L53 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
T87 M87 Biomuta DOID:10283 / prostate cancer [ icgc ]
T260 R260 Biomuta DOID:4159 / skin cancer [ cosmic ]
T260 M260 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C301 Y301 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T445 I445 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S524 * Biomuta DOID:4362 / cervical cancer [ cosmic ]