Protein Information

Cytoscape View


UniProt AC / UniProt ID P09884 / DPOLA_HUMAN
Protein Name DNA polymerase alpha catalytic subunit
Gene Name Name: POLA1
Synonyms:POLA;
Organism Homo sapiens (Human)

PRO ID PR:P09884
DAG View
PRO Name DNA polymerase alpha catalytic subunit (human)
Definition A DNA polymerase alpha catalytic subunit that is encoded in the genome of human.
Short Label hPOLA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09884 (POLA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus
Y49 Phosphorylation PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
Y66 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
T129 Phosphorylation HPRD   PhosphoSitePlus 19413330
K130 Acetylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
T174 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 20068231
S186 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 19651622, ...18669648, 19690332, 20068231
S190 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S195 Phosphorylation HPRD   PhosphoSitePlus 20068231
T198 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T200 Phosphorylation PhosphoSitePlus
S209 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...19007248, 18669648, 20068231
S212 Phosphorylation HPRD   PhosphoSitePlus 20068231
T219 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
K271 Acetylation PhosphoSitePlus
S277 Phosphorylation PhosphoSitePlus
K284 Sumoylation PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus   UniProt 23186163
K411 Ubiquitination PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
K599 Acetylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
K604 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K829 Ubiquitination PhosphoSitePlus
K848 Ubiquitination PhosphoSitePlus
K930 Ubiquitination PhosphoSitePlus
Y942 Phosphorylation PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
Y1000 Phosphorylation PhosphoSitePlus
K1031 Ubiquitination PhosphoSitePlus
K1054 Ubiquitination PhosphoSitePlus
Y1055 Phosphorylation PhosphoSitePlus
K1071 Ubiquitination PhosphoSitePlus
K1075 Ubiquitination PhosphoSitePlus
K1089 Ubiquitination PhosphoSitePlus
K1114 Ubiquitination PhosphoSitePlus
K1141 Ubiquitination PhosphoSitePlus
K1200 Ubiquitination PhosphoSitePlus
T1268 Phosphorylation PhosphoSitePlus
K1272 Ubiquitination PhosphoSitePlus
S1327 Phosphorylation PhosphoSitePlus
K1376 Ubiquitination PhosphoSitePlus
K1419 Ubiquitination PhosphoSitePlus
K1434 Methylation PhosphoSitePlus
K1434 Ubiquitination PhosphoSitePlus
S1462 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T129 A129 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K144 N144 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T200 M200 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K590 N590 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K590 R590 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K599 R599 Biomuta DOID:2994 / germ cell cancer [ tcga ]
K661 N661 Biomuta DOID:4362 / cervical cancer [ tcga ]
K829 T829 Biomuta DOID:363 / uterine cancer [ tcga ]
K848 R848 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y1055 H1055 Biomuta DOID:363 / uterine cancer [ tcga ]
S1462 Y1462 Biomuta DOID:363 / uterine cancer [ tcga ]
S1462 F1462 Biomuta DOID:1909 / melanoma [ icgc, tcga ]