Protein Information

Cytoscape View


UniProt AC / UniProt ID P09769 / FGR_HUMAN
Protein Name Tyrosine-protein kinase Fgr
Gene Name Name: FGR
Synonyms:SRC2;
Organism Homo sapiens (Human)

PRO ID PR:P09769
DAG View
PRO Name tyrosine-protein kinase Fgr (human)
Definition A tyrosine-protein kinase Fgr that is encoded in the genome of human.
Short Label hFGR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09769 (FGR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Ubiquitination PhosphoSitePlus
Y28 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
Y34 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18083107
Y86 Phosphorylation PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
T176 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
Y209 Phosphorylation PhosphoSitePlus
T211 Phosphorylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
S341 Phosphorylation PhosphoSitePlus
Y412 Phosphorylation P09769 (FGR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 18083107, 8612628, 7515063, ...19369195
T453 Phosphorylation PhosphoSitePlus
Y459 Phosphorylation PhosphoSitePlus
Y523 Phosphorylation P41240 (CSK) , P09769 (FGR) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 8612628, 7515063


P09769 (FGR) as PTM Enzyme



Substrate Site Score Source PMID
P09769 (FGR) Y412 HPRD   neXtProt   phospho.ELM 8612628, 7515063
P09769 (FGR) Y523 neXtProt 7515063
P12931-1 (SRC) Y530 HPRD 12387813, 12468645, 9208935, ...7678701
P14317-1 (HCLS1) Y222 HPRD   neXtProt   phospho.ELM 10066823
P14317 (HCLS1) Y397 phospho.ELM 9183008
P31040 (SDHA) Y543 neXtProt 17997986
P31040 (SDHA) Y604 neXtProt 17997986
P37840-1 (SNCA) Y125 HPRD 12096713, 11162638, 11744621
P68400 (CSNK2A1) Y255 neXtProt   phospho.ELM 12628006
Q05397 (PTK2) Y397 neXtProt   PhosphoSitePlus 12387730, 15561106
Q05397 (PTK2) Y576 neXtProt   PhosphoSitePlus 12387730, 15561106
Q05397 (PTK2) Y925 neXtProt   PhosphoSitePlus   Signor 12387730
Q99798 (ACO2) Y71 neXtProt 17997986
Q99798 (ACO2) Y544 neXtProt 17997986
Q99798 (ACO2) Y665 neXtProt 17997986


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04626 (ERBB2) Y1139 P09769 (FGR) unknown eFIP 16273093
Phosphorylation P09917 (ALOX5) S53 P09769 (FGR) unknown eFIP 24860872
Phosphorylation Q8IZP0 (ABI1) Y421 P09769 (FGR) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S181 F181 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
S261 G261 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T453 P453 Biomuta DOID:1909 / melanoma [ icgc, tcga ]