iPTMnet Report for P09651 (HNRNPA1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P09651 / ROA1_HUMAN
Protein Name Heterogeneous nuclear ribonucleoprotein A1
Gene Name Name: HNRNPA1
Synonyms:HNRPA1;
Organism Homo sapiens (Human)

PRO ID PR:P09651
DAG View
PRO Name heterogeneous nuclear ribonucleoprotein A1 (human)
Definition A heterogeneous nuclear ribonucleoprotein A1 that is encoded in the genome of human.
Short Label hHNRNPA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09651 (HNRNPA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
S2 Acetylation UniProt 22814378, 20068231
S2 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14729942, 23186163, 20068231
K3 Acetylation PhosphoSitePlus   UniProt 19608861
K3 Sumoylation PhosphoSitePlus
K3 Ubiquitination PhosphoSitePlus
S4 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 21406692, 23186163, 17081983, ...18220336, 18669648, 20068231, 25324306
S4 Phosphorylation Q9UBS0 (RPS6KB2) RLIMS-P+ 25324306
S6 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 21406692, 23186163, 17081983, ...18669648, 17287340, 29344170, 20068231, 25324306
S6 Phosphorylation Q9UBS0 (RPS6KB2) RLIMS-P+ 25324306
K8 Acetylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
R14 Methylation PhosphoSitePlus
K15 Acetylation PhosphoSitePlus
K15 Sumoylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S22 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...34725712, 30444036, 21740066, 30059200, 35132862, 27913144, 35083852, 31492838, 20305658, 32119511, 29351928, 22121020, 31373491, 29237092
S22 Phosphorylation PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
S29 Phosphorylation PhosphoSitePlus
R31 Methylation PhosphoSitePlus
C43 S-Nitrosylation dbSNO 20140087, 22178444
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
R55 Methylation PhosphoSitePlus
T61 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K87 Acetylation PhosphoSitePlus
K87 Sumoylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
S91 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S95 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 25999341, 7727389, 19656952, ...17287340
S95 Phosphorylation P17252 (PRKCA) Signor 7727389
T103 Phosphorylation PhosphoSitePlus
K105 Acetylation PhosphoSitePlus
K105 Sumoylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K106 Methylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Sumoylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
R122 Methylation PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
T138 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
R140 Methylation PhosphoSitePlus
S142 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K144 Acetylation PhosphoSitePlus
K144 Sumoylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K145 Acetylation PhosphoSitePlus
R146 Methylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
K161 Methylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
Y167 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
T169 Phosphorylation PhosphoSitePlus
C175 S-Nitrosylation dbSNO 26338901
K183 Sumoylation PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S192 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 25999341, 19656952, 16111636
S192 Phosphorylation Q9BUB5 (MKNK1) PhosphoSitePlus 16111636
R194 Methylation PhosphoSitePlus   UniProt 15782174
R196 Methylation PhosphoSitePlus
S197 Phosphorylation PhosphoSitePlus
S199 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 34080184, 21406692, 33319070, ...18562319, 21454539, 8451194
S199 Phosphorylation P17612 (PRKACA) neXtProt 8451194
S199 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   Signor 18562319
S199 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 8451194
R206 Methylation PhosphoSitePlus   UniProt 24129315, 15782174
R218 Methylation PhosphoSitePlus   UniProt 24129315
R225 Methylation PhosphoSitePlus   UniProt 24129315, 15782174
R232 Methylation PhosphoSitePlus   UniProt 24129315
Y244 Phosphorylation PhosphoSitePlus
Y253 Phosphorylation PhosphoSitePlus
R265 Methylation PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
Y318 Phosphorylation PhosphoSitePlus
K329 Sumoylation PhosphoSitePlus
R336 Methylation PhosphoSitePlus   UniProt 24129315
S337 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...34725712, 30444036, 21740066, 30059200, 35132862, 27913144, 35083852, 31492838, 20305658, 32119511, 29351928, 22121020, 31373491, 29237092
S337 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 18220336
S338 O-Glycosylation GlyGen 31373491
S338 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
Y341 Phosphorylation PhosphoSitePlus
Y347 Phosphorylation phospho.ELM   PhosphoSitePlus 15592455, 18083107
K350 Acetylation PhosphoSitePlus   UniProt 19608861
K350 Methylation PhosphoSitePlus
K350 Sumoylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
R352 Methylation PhosphoSitePlus   UniProt 24129315
Y357 Phosphorylation PhosphoSitePlus
S360 O-Glycosylation GlyGen 32574038, 31373491
S360 Phosphorylation PhosphoSitePlus
S361 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...34725712, 30444036, 21740066, 30059200, 35132862, 27913144, 35083852, 31492838, 20305658, 32119511, 29351928, 22121020, 31373491, 29237092
S361 Phosphorylation PhosphoSitePlus   UniProt 23186163
S362 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...34725712, 30444036, 21740066, 30059200, 35132862, 27913144, 35083852, 31492838, 20305658, 32119511, 29351928, 22121020, 31373491, 29237092
S362 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 16111636
S362 Phosphorylation Q9BUB5 (MKNK1) PhosphoSitePlus 16111636
S363 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...34725712, 30444036, 21740066, 30059200, 35132862, 27913144, 35083852, 30620550, 31492838, 20305658, 32119511, 29351928, 22121020, 31373491, 29237092
S363 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16111636
S363 Phosphorylation Q9BUB5 (MKNK1) PhosphoSitePlus 16111636
S364 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...34725712, 30444036, 21740066, 30059200, 35132862, 27913144, 35083852, 31492838, 20305658, 32119511, 29351928, 22121020, 31373491, 29237092
S364 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16111636
S364 Phosphorylation Q9BUB5 (MKNK1) PhosphoSitePlus 16111636
S365 O-Glycosylation GlyGen 33214551, 34019948, 32574038, ...34725712, 30444036, 21740066, 30059200, 35132862, 27913144, 35083852, 31492838, 20305658, 32119511, 29351928, 22121020, 31373491, 29237092
S365 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163
Y366 Phosphorylation PhosphoSitePlus
S368 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
R370 Methylation PhosphoSitePlus   UniProt 24129315
R371 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 17081983, 20068231
S4 Phosphorylation HPRD 17322306, 18767875, 19664995, ...18452278, 19651622, 18669648, 18707149, 20166139, 20068231
S6 Phosphorylation HPRD 17287340, 18212344, 8288564, ...18767875, 19664995, 18452278, 19651622, 14729942, 18669648, 18707149, 20166139, 17924679, 20068231, 20068230
S91 Phosphorylation HPRD 17287340
S95 Phosphorylation HPRD 17287340
T138 Phosphorylation HPRD 20068231
S142 Phosphorylation HPRD 18669648, 20068231
Y167 Phosphorylation HPRD 17287340
S337 Phosphorylation HPRD 18669648, 20068231
S338 Phosphorylation HPRD 17287340, 20068231
Y347 Phosphorylation HPRD 15592455, 19901323
Y357 Phosphorylation HPRD 19413330
S360 Phosphorylation HPRD 19413330
S361 Phosphorylation HPRD 19413330
S362 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S363 Phosphorylation HPRD 19413330, 18212344, 19664995
S364 Phosphorylation HPRD 19413330, 18669648, 19664995
S365 Phosphorylation HPRD 19413330, 18212344, 19664995
S368 Phosphorylation HPRD 19413330, 18669648, 19664995
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 17081983, 20068231
S4 Phosphorylation HPRD 17322306, 18767875, 19664995, ...18452278, 19651622, 18669648, 18707149, 20166139, 20068231
S6 Phosphorylation HPRD 17287340, 18212344, 18767875, ...19664995, 18452278, 19651622, 14729942, 18669648, 18707149, 20166139, 17924679, 20068231, 20068230
S91 Phosphorylation HPRD 17287340
S95 Phosphorylation HPRD 17287340
T138 Phosphorylation HPRD 20068231
S142 Phosphorylation HPRD 18669648, 20068231
Y167 Phosphorylation HPRD 17287340
R225 Methylation PhosphoSitePlus
R232 Methylation PhosphoSitePlus
S285 Phosphorylation HPRD 18669648, 20068231
S286 Phosphorylation HPRD 17287340, 20068231
Y295 Phosphorylation HPRD 15592455, 19901323
Y305 Phosphorylation HPRD 19413330
S308 Phosphorylation HPRD 19413330
S309 Phosphorylation HPRD 19413330
S310 Phosphorylation HPRD 19413330, 18669648, 19664995, ...20068231
S311 Phosphorylation HPRD 19413330, 18212344, 19664995
S312 Phosphorylation HPRD 19413330, 18669648, 19664995
S313 Phosphorylation HPRD 19413330, 18212344, 19664995
S316 Phosphorylation HPRD 19413330, 18669648, 19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 C2 Biomuta DOID:1324 / lung cancer [ cosmic ]
K3 N3 Biomuta DOID:3571 / liver cancer [ cosmic ]
S6 F6 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S6 Y6 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R14 S14 Biomuta DOID:4159 / skin cancer [ cosmic ]
S22 T22 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R31 M31 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R55 S55 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S91 F91 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S91 C91 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ]
K106 N106 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R122 K122 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y124 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T138 S138 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R140 Q140 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R146 M146 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R146 K146 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y167 C167 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T169 A169 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R194 T194 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R206 G206 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R218 H218 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y244 C244 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R265 T265 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y295 N295 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S310 N310 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S313 T313 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ] DOID:3571 / liver cancer [ icgc ] DOID:263 / kidney cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
Y347 N347 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R352 * Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S362 N362 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S365 T365 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y366 C366 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R371 T371 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:11934 / head and neck cancer [ icgc ]