Protein Information

Cytoscape View


UniProt AC / UniProt ID P09622 / DLDH_HUMAN
Protein Name Dihydrolipoyl dehydrogenase, mitochondrial precursor
Gene Name Name: DLD
Synonyms:GCSL,LAD,PHE3;
Organism Homo sapiens (Human)

PRO ID PR:P09622
DAG View
PRO Name dihydrolipoyl dehydrogenase, mitochondrial (human)
Definition A dihydrolipoyl dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hDLD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09622 (DLD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K66 Acetylation PhosphoSitePlus
K66 Methylation PhosphoSitePlus
K72 Acetylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
R109 Methylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
K143 Acetylation PhosphoSitePlus   UniProt 19608861
K143 Methylation PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
Y153 Phosphorylation PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
K166 Ubiquitination PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
K267 Acetylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K271 Acetylation PhosphoSitePlus
K273 Acetylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
K277 Acetylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
K320 Acetylation PhosphoSitePlus
K320 Ubiquitination PhosphoSitePlus
K346 Acetylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K410 Acetylation PhosphoSitePlus   UniProt 19608861
K410 Ubiquitination PhosphoSitePlus
K417 Acetylation PhosphoSitePlus   UniProt 19608861
K417 Ubiquitination PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus   UniProt 23186163
K505 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T276 Phosphorylation HPRD 20068231
T341 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K146 M146 Biomuta DOID:1324 / lung cancer [ cosmic ]
K320 N320 Biomuta DOID:363 / uterine cancer [ tcga ]
K320 M320 Biomuta DOID:1324 / lung cancer [ tcga ]
K417 E417 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K430 N430 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S502 A502 Biomuta DOID:363 / uterine cancer [ tcga ]