iPTMnet Report for P09619 (PDGFRB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P09619 / PGFRB_HUMAN
Protein Name Platelet-derived growth factor receptor beta precursor
Gene Name Name: PDGFRB
Synonyms:PDGFR,PDGFR1;
Organism Homo sapiens (Human)

PRO ID PR:P09619
DAG View
PRO Name platelet-derived growth factor receptor beta (human)
Definition A beta-type platelet-derived growth factor receptor that is encoded in the genome of human.
Short Label hPDGFRB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09619 (PDGFRB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N89 N-Glycosylation GlyGen   UniProt 20534510
N103 N-Glycosylation GlyGen   UniProt 20534510
S212 Phosphorylation PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
N215 N-Glycosylation GlyGen   UniProt 20534510, 29391424
N230 N-Glycosylation GlyGen   UniProt 20534510
S254 Phosphorylation PhosphoSitePlus   RLIMS-P 35066967
N292 N-Glycosylation GlyGen   UniProt 20534510
N307 N-Glycosylation GlyGen   UniProt 20534510, 29391424
N371 N-Glycosylation GlyGen 29391424
Y562 Phosphorylation P09619 (PDGFRB) phospho.ELM   PhosphoSitePlus   UniProt 10821867
Y579 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 7685273, 15902258, 9642269, ...7687537, 8195171, 12706723, 14966296, 9742401, 24165129, 2550144, 34360683
Y581 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 7685273, 15902258, 9642269, ...12706723, 8617789, 9742401, 2550144
T605 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
K645 Ubiquitination PhosphoSitePlus
Y678 Phosphorylation PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
Y686 Phosphorylation P42684 (ABL2) , P00519 (ABL1) PhosphoSitePlus   Signor 19275932
Y692 Phosphorylation PhosphoSitePlus
S705 Phosphorylation PhosphoSitePlus
K707 Ubiquitination PhosphoSitePlus
S712 Phosphorylation PhosphoSitePlus
Y716 Phosphorylation P09619 (PDGFRB) IntAct   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 16288304, 15902258, 7935391, ...26631574, 8940081, 18567737
S717 Phosphorylation PhosphoSitePlus
Y740 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 9512716, 15902258, 1375321, ...10752619, 7876130, 8382774, 8195171, 1314164, 7683666, 7545675, 11710529, 8670861, 17403678, 8382612, 1330535, 11896612
Y751 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17961557, 10336465, 8195171, ...8564419, 11710529, 7680644, 2550144, 1375321, 8382774, 24648957, 14966296, 1709159, 33509954, 7683666, 10752619, 9153411, 7876130, 7536927, 10821867, 7545675, 8670861, 1330535, 18567737, 7692233, 33093618, 2170111, 1314164, 28487538, 17403678
Y763 Phosphorylation P09619 (PDGFRB) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 10821867, 10391677, 17403678
Y771 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 10733900, 15902258, 10821867, ...1375321, 8382774, 8195171, 10454568, 7545675, 14966296, 26631574, 33509954, 1314164
Y775 Phosphorylation P09619 (PDGFRB) IntAct   phospho.ELM   PRO   PhosphoSitePlus   UniProt 8940081, 10821867
Y778 Phosphorylation P09619 (PDGFRB) phospho.ELM   PRO   PhosphoSitePlus   UniProt 9394017, 10821867
Y857 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 15902258, 10821867, 15763428, ...1314164, 26104298, 24165129, 2550144, 1709159, 1661130, 34360683
Y921 Phosphorylation PhosphoSitePlus
S930 Phosphorylation PhosphoSitePlus
Y934 Phosphorylation P00519 (ABL1) PhosphoSitePlus   RLIMS-P   Signor 19275932, 25569182
Y970 Phosphorylation P00519 (ABL1) PhosphoSitePlus   Signor 19275932
Y1009 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8183548, 15902258, 7678051, ...10391677, 1396585, 8195171, 25569182, 11027258, 7545675, 17403678, 8538796, 7688466, 7530043, 33509954, 10821867
Y1021 Phosphorylation P09619 (PDGFRB) IntAct   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8555205, 9989826, 7678051, ...27048651, 1396585, 7876130, 11896612, 10821867, 12062403, 15902258, 7545675, 26104298, 14966296, 26631574, 10373546, 8181064, 15641795, 8119896, 33509954, 17620338
S1104 Phosphorylation phospho.ELM   PhosphoSitePlus 15271984
Site PTM Type PTM Enzyme Score Source PMID
Y579 Phosphorylation P09619 (PDGFRB) HPRD 8195171
Y581 Phosphorylation P09619 (PDGFRB) HPRD 8617789
Y716 Phosphorylation P09619 (PDGFRB) HPRD 7935391
Y740 Phosphorylation P09619 (PDGFRB) HPRD 8195171
Y751 Phosphorylation P09619 (PDGFRB) HPRD 8195171
Y763 Phosphorylation P09619 (PDGFRB) HPRD 10391677
Y771 Phosphorylation P09619 (PDGFRB) HPRD 8195171
Y775 Phosphorylation P09619 (PDGFRB) HPRD 8940081
Y857 Phosphorylation P09619 (PDGFRB) HPRD   PRO 9642269, 15271984, 15994317, ...1653029, 10821867
Y934 Phosphorylation HPRD 18491316
Y1009 Phosphorylation P09619 (PDGFRB) HPRD 8195171
Y1021 Phosphorylation P09619 (PDGFRB) HPRD 12062403
S1104 Phosphorylation PRO 15271984, 15994317


P09619 (PDGFRB) as PTM Enzyme



Substrate Site Score Source PMID
P06241-2 (FYN) Y28 HPRD   PhosphoSitePlus 9425276
P09619 (PDGFRB) Y562 PhosphoSitePlus   UniProt 10821867
P09619 (PDGFRB) Y579 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 9642269, 2550144, 8195171, ...14966296
P09619 (PDGFRB) Y581 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 15902258, 9642269, 2550144, ...8617789
P09619-1 (PDGFRB) Y716 HPRD   UniProt 15902258, 7935391
P09619 (PDGFRB) Y740 HPRD   neXtProt   PhosphoSitePlus   UniProt 7545675, 8195171, 1314164, ...1375321
P09619-1 (PDGFRB) Y751 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 2550144, 8195171, 7545675, ...10821867, 1375321
P09619 (PDGFRB) Y763 HPRD   PhosphoSitePlus   UniProt 10821867, 10391677
P09619 (PDGFRB) Y771 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 8195171, 7545675, 10821867, ...1314164, 1375321
P09619 (PDGFRB) Y775 HPRD   PhosphoSitePlus   UniProt 8940081, 10821867
P09619 (PDGFRB) Y778 PhosphoSitePlus   UniProt 10821867
P09619 (PDGFRB) Y857 HPRD   neXtProt   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 2550144, 10821867, 15763428
P09619 (PDGFRB) Y1009 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 10821867, 10391677, 1396585, ...8195171, 7545675, 7678051
P09619 (PDGFRB) Y1021 HPRD   neXtProt   PhosphoSitePlus   Signor   UniProt 1396585, 7545675, 7678051, ...12062403, 10821867
P12931 (SRC) Y139 neXtProt 9010229
P12931 (SRC) Y419 PhosphoSitePlus   Signor 15489898, 15994317
P15941 (MUC1) Y1203 neXtProt   PhosphoSitePlus 17545600
P15941 (MUC1) Y1218 neXtProt   PhosphoSitePlus 17545600
P16234 (PDGFRA) Y754 neXtProt   PhosphoSitePlus 10417313, 7523122
P27986 (PIK3R1) Y508 neXtProt 8086421
P34947 (GRK5) Y90 neXtProt 19092051
P34947 (GRK5) Y109 neXtProt 19092051
P34947 (GRK5) Y309 neXtProt 19092051
P34947 (GRK5) Y368 neXtProt 19092051
P42684 (ABL2) Y139 PhosphoSitePlus 19275932
P42684 (ABL2) Y161 PhosphoSitePlus 19275932
P42684 (ABL2) Y272 PhosphoSitePlus 19275932
Q05397 (PTK2) Y5 neXtProt   PhosphoSitePlus   Signor 20802513
Q05397 (PTK2) Y194 neXtProt   PhosphoSitePlus   Signor 20802513
Q05655 (PRKCD) Y313 neXtProt 18387943
Q05655 (PRKCD) Y334 neXtProt 18387943
Q06124-2 (PTPN11) Y542 HPRD 8041791
Q07912 (TNK2) Y635 PhosphoSitePlus 25257795
Q13480 (GAB1) Y627 neXtProt 14973141
Q13480 (GAB1) Y659 neXtProt 14973141
Q13769 (THOC5) Y225 PhosphoSitePlus 18373705


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048726 (hPDGFRB/SigPep-/Phos:1) pY579,pY581,pY716,pY740,pY751,pY763,pY771,pY775,pY778,pY857,pY1009,pY1021 PRO
PR:000049846 (hPDGFRB/SigPep-/Phos:2) pY857 PRO 1653029, 9642269
PR:000049847 (hPDGFRB/SigPep-/Phos:3) pY857,pS1104 PRO 15271984, 15994317


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000049846 (hPDGFRB/SigPep-/Phos:2) increased Interaction PR:P20936 (hRASA1) PRO 1653029
PR:000049847 (hPDGFRB/SigPep-/Phos:3) decreased Interaction PR:O14745 (hSLC9A3R1) PRO 15271984


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N89 K89 Biomuta DOID:1324 / lung cancer [ cosmic ]
N307 D307 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y562 C562 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
S608 Y608 Biomuta DOID:1324 / lung cancer [ cosmic ]
K645 T645 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y686 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S705 F705 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y716 H716 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y751 C751 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y763 C763 Biomuta DOID:363 / uterine cancer [ cosmic ]
Y778 C778 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
Y778 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y921 * Biomuta DOID:1612 / breast cancer [ cosmic ]
Y1009 S1009 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1104 N1104 Biomuta DOID:9256 / colorectal cancer [ cosmic ]