iPTMnet Report for P09601 (HMOX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P09601 / HMOX1_HUMAN
Protein Name Heme oxygenase 1
Gene Name Name: HMOX1
Synonyms:HO,HO1;
Organism Homo sapiens (Human)

PRO ID PR:P09601
DAG View
PRO Name heme oxygenase 1 (human)
Definition A heme oxygenase 1 that is encoded in the genome of human.
Short Label hHMOX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09601 (HMOX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K18 Acetylation PhosphoSitePlus
K18 Ubiquitination PhosphoSitePlus
K22 Ubiquitination PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
Y55 Phosphorylation PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K86 Ubiquitination PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
Y114 Phosphorylation PhosphoSitePlus
Y137 Phosphorylation HPRD   PhosphoSitePlus 20068231
K148 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
S188 Phosphorylation P31749 (AKT1) HPRD   neXtProt   PhosphoSitePlus   RLIMS-P   Signor 15581622
T192 Phosphorylation PhosphoSitePlus
S229 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 17081983, 18767875, ...19651622, 20068231
S231 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18578522, 17081983, 18767875, ...19651622, 20068231
K243 Acetylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
T252 Phosphorylation PhosphoSitePlus
K256 Acetylation PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
Y286 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K18 N18 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K18 T18 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K148 E148 Biomuta DOID:3571 / liver cancer [ cosmic ]
S160 Y160 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S188 F188 Biomuta DOID:4159 / skin cancer [ cosmic ]
S231 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K256 R256 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y286 S286 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y286 H286 Biomuta DOID:1324 / lung cancer [ cosmic ]