iPTMnet Report for P09543 (CNP)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P09543 / CN37_HUMAN
Protein Name 2',3'-cyclic-nucleotide 3'-phosphodiesterase precursor
Gene Name Name: CNP
Organism Homo sapiens (Human)

PRO ID PR:P09543
DAG View
PRO Name 2',3'-cyclic-nucleotide 3'-phosphodiesterase (human)
Definition A 2',3'-cyclic-nucleotide 3'-phosphodiesterase that is encoded in the genome of human.
Short Label hCNP
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09543 (CNP) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus   UniProt 23186163
K8 Ubiquitination PhosphoSitePlus
S9 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 10646504
T11 Phosphorylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
S22 Phosphorylation phospho.ELM   PhosphoSitePlus 10646504
S24 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
Y86 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
C111 S-Nitrosylation dbSNO 26338901
Y141 Phosphorylation PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus   UniProt 23186163
K175 Acetylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
Y241 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
T292 Phosphorylation PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
Y373 Phosphorylation PhosphoSitePlus
T383 Phosphorylation PhosphoSitePlus
T406 Phosphorylation PhosphoSitePlus
S409 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S170 Phosphorylation HPRD 19413330, 20166139, 19664994
S312 Phosphorylation HPRD 18510355
S318 Phosphorylation HPRD 18510355


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T11 A11 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K15 N15 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S22 L22 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K87 R87 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K164 N164 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
S170 L170 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K217 R217 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K235 N235 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K255 N255 Biomuta DOID:363 / uterine cancer [ icgc ]
K275 N275 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T292 A292 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
K316 M316 Biomuta DOID:3571 / liver cancer [ cosmic ]