Protein Information

Cytoscape View


UniProt AC / UniProt ID P09493 / TPM1_HUMAN
Protein Name Tropomyosin alpha-1 chain
Gene Name Name: TPM1
Synonyms:C15orf13,TMSA;
Organism Homo sapiens (Human)

PRO ID PR:P09493
DAG View
PRO Name tropomyosin alpha-1 chain (human)
Definition A tropomyosin alpha-1 chain that is encoded in the genome of human.
Short Label hTPM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P09493 (TPM1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 3548719
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
K15 Acetylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
K29 Acetylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
K48 Acetylation PhosphoSitePlus
K48 Ubiquitination PhosphoSitePlus
T53 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
S61 Phosphorylation P42336 (PIK3CA) phospho.ELM   PhosphoSitePlus 16094730
K77 Ubiquitination PhosphoSitePlus
T79 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
K112 Acetylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K118 Acetylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S123 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
K161 Methylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus   UniProt 24275569
T199 Phosphorylation PhosphoSitePlus
T201 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
Y214 Phosphorylation PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
K231 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
Y261 Phosphorylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
Y267 Phosphorylation PhosphoSitePlus
K268 Ubiquitination PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S283 Phosphorylation P53355 (DAPK1) neXtProt   PhosphoSitePlus   Signor   UniProt 17895359
Site PTM Type PTM Enzyme Score Source PMID
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S229 Phosphorylation HPRD   PhosphoSitePlus 18452278
S283 Phosphorylation HPRD   PhosphoSitePlus 278975
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
K195 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
S213 Phosphorylation PhosphoSitePlus
T221 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K29 Acetylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K213 Acetylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
S215 Phosphorylation PhosphoSitePlus
S229 Phosphorylation HPRD   PhosphoSitePlus 18452278
K251 Acetylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
S252 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648, 18212344
K259 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T277 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation PhosphoSitePlus
S16 Phosphorylation PhosphoSitePlus
S51 Phosphorylation HPRD   PhosphoSitePlus 20068231
Site PTM Type PTM Enzyme Score Source PMID
S70 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S252 Phosphorylation HPRD 19651622, 18669648, 18212344
Site PTM Type PTM Enzyme Score Source PMID
S229 Phosphorylation HPRD 18452278
S252 Phosphorylation HPRD 19651622, 18669648, 18212344
Site PTM Type PTM Enzyme Score Source PMID
S252 Phosphorylation HPRD 19651622, 18669648, 18212344


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P20963 (CD247) Y142 P09493 (TPM1) unknown eFIP 24502978


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 I1 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K48 E48 Biomuta DOID:363 / uterine cancer [ tcga ]
Y60 C60 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K77 R77 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
K118 * Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R160 C160 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T201 M201 Biomuta DOID:363 / uterine cancer [ tcga ]