Protein Information

Cytoscape View

UniProt AC / UniProt ID P09429 / HMGB1_HUMAN
Protein Name High mobility group protein B1
Gene Name Name: HMGB1
Organism Homo sapiens (Human)

PRO ID PR:P09429
DAG View
PRO Name high mobility group protein B1 (human)
Definition A high mobility group protein B1 that is encoded in the genome of human.
Short Label hHMGB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P09429 (HMGB1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K3 Acetylation PhosphoSitePlus
K3 Methylation PhosphoSitePlus
K12 Acetylation PhosphoSitePlus
K12 Ubiquitination PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
C23 S-Nitrosylation dbSNO 26338901
R24 Methylation PhosphoSitePlus
K30 Acetylation PhosphoSitePlus   UniProt 19608861
K30 Ubiquitination PhosphoSitePlus
S35 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17287340, 18669648, ...23186163, 20068231
S39 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
K43 Methylation PhosphoSitePlus
K43 Ubiquitination PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
S46 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
T51 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K55 Acetylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Methylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K65 Acetylation PhosphoSitePlus
K65 Ubiquitination PhosphoSitePlus
Y71 Phosphorylation PhosphoSitePlus
K76 Acetylation PhosphoSitePlus
K76 Ubiquitination PhosphoSitePlus
T77 Phosphorylation PhosphoSitePlus
Y78 Phosphorylation PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
K90 Acetylation PhosphoSitePlus
K90 Ubiquitination PhosphoSitePlus
S100 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20058876
C106 S-Nitrosylation dbSNO 26338901
S107 Phosphorylation PhosphoSitePlus
Y109 Phosphorylation HPRD   PhosphoSitePlus 20068231
K112 Methylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
K114 Methylation PhosphoSitePlus
K114 Sumoylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
S121 Phosphorylation HPRD   PhosphoSitePlus 20068231
K127 Ubiquitination PhosphoSitePlus
K128 Acetylation PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
T136 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K147 Ubiquitination PhosphoSitePlus
K154 Acetylation PhosphoSitePlus
Y155 Phosphorylation HPRD   PhosphoSitePlus 17287340
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation HPRD   PhosphoSitePlus 17287340, 20068230
K173 Acetylation PhosphoSitePlus
K177 Acetylation PhosphoSitePlus
K177 Sumoylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y16 N16 Biomuta DOID:1324 / lung cancer [ tcga ]
C23 F23 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R24 Q24 Biomuta DOID:3571 / liver cancer [ icgc ]
S35 L35 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K44 T44 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
T51 S51 Biomuta DOID:184 / bone cancer [ icgc ] DOID:3371 / chondrosarcoma [ cosmic ]
S53 F53 Biomuta DOID:363 / uterine cancer [ tcga ]
Y78 F78 Biomuta DOID:1324 / lung cancer [ icgc, tcga ]
S107 F107 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S107 C107 Biomuta DOID:3571 / liver cancer [ tcga ]
S121 P121 Biomuta DOID:10534 / stomach cancer [ tcga ]
K141 T141 Biomuta DOID:1612 / breast cancer [ icgc ]