iPTMnet Report for P08922 (ROS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08922 / ROS1_HUMAN
Protein Name Proto-oncogene tyrosine-protein kinase ROS precursor
Gene Name Name: ROS1
Synonyms:MCF3,ROS;
Organism Homo sapiens (Human)

PRO ID PR:P08922
DAG View
PRO Name proto-oncogene tyrosine-protein kinase ROS (human)
Definition A proto-oncogene tyrosine-protein kinase ROS that is encoded in the genome of human.
Short Label hROS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08922 (ROS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y135 Phosphorylation PhosphoSitePlus
T143 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
T145 Phosphorylation PhosphoSitePlus
T188 Phosphorylation PhosphoSitePlus
T196 Phosphorylation PhosphoSitePlus
Y800 Phosphorylation PhosphoSitePlus
Y802 Phosphorylation PhosphoSitePlus
Y807 Phosphorylation PhosphoSitePlus
S818 Phosphorylation PhosphoSitePlus
S1185 Phosphorylation PhosphoSitePlus
T1190 Phosphorylation PhosphoSitePlus
K1259 Acetylation PhosphoSitePlus
S1273 Phosphorylation PhosphoSitePlus
T1274 Phosphorylation PhosphoSitePlus
T1375 Phosphorylation PhosphoSitePlus
Y1491 Phosphorylation IEDB 35494241
K1504 Acetylation PhosphoSitePlus
S1570 O-Glycosylation GlyGen 29237092
S1577 O-Glycosylation GlyGen 29237092
S1581 O-Glycosylation GlyGen 29237092
K1749 Acetylation PhosphoSitePlus
Y1923 Phosphorylation PhosphoSitePlus
T1927 Phosphorylation PhosphoSitePlus
T1930 Phosphorylation PhosphoSitePlus
K1944 Acetylation PhosphoSitePlus
S2002 Phosphorylation PhosphoSitePlus
Y2023 Phosphorylation PhosphoSitePlus
Y2069 Phosphorylation PhosphoSitePlus
Y2110 Phosphorylation IntAct   PhosphoSitePlus 17416557
Y2114 Phosphorylation IntAct   PhosphoSitePlus 17416557
Y2115 Phosphorylation IntAct   PhosphoSitePlus 17416557
Y2173 Phosphorylation PhosphoSitePlus
Y2227 Phosphorylation PhosphoSitePlus
Y2274 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 11266449, 28759046, 15456853, ...12538861, 23292247
Y2274 Phosphorylation P08922 (ROS1) UniProt 12538861
Y2323 Phosphorylation PhosphoSitePlus
S2326 Phosphorylation PhosphoSitePlus
Y2334 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15456853, 12538861
Y2334 Phosphorylation P08922 (ROS1) UniProt 12538861
T2338 Phosphorylation PhosphoSitePlus
Y2342 Phosphorylation PhosphoSitePlus
S2346 Phosphorylation PhosphoSitePlus


P08922 (ROS1) as PTM Enzyme



Substrate Site Score Source PMID
P08922 (ROS1) Y2274 UniProt 12538861
P08922 (ROS1) Y2334 UniProt 12538861


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y144 H144 Biomuta DOID:363 / uterine cancer [ icgc ]
T145 P145 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ] DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
Y800 C800 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
Y802 C802 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y807 C807 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1273 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1273 L1273 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1274 K1274 Biomuta DOID:263 / kidney cancer [ cosmic ]
T1274 A1274 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1570 T1570 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1581 C1581 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S1581 F1581 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1930 A1930 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1930 I1930 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1944 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S2002 N2002 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
Y2110 C2110 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y2173 C2173 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y2323 F2323 Biomuta DOID:1612 / breast cancer [ cosmic ]
S2326 F2326 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S2326 C2326 Biomuta DOID:1324 / lung cancer [ cosmic ]
T2338 S2338 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
Y2342 H2342 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]