iPTMnet Report for P08887 (IL6R)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08887 / IL6RA_HUMAN
Protein Name Interleukin-6 receptor subunit alpha precursor
Gene Name Name: IL6R
Organism Homo sapiens (Human)

PRO ID PR:P08887
DAG View
PRO Name interleukin-6 receptor subunit alpha (human)
Definition An interleukin-6 receptor subunit alpha that is encoded in the genome of human.
Short Label hIL6R
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08887 (IL6R) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N55 N-Glycosylation GlyGen   UniProt 10066782, 28060820, 24190977
S91 Phosphorylation PhosphoSitePlus
N93 N-Glycosylation GlyGen   UniProt 23090970, 10066782, 28060820, ...24190977
T139 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
T144 Phosphorylation PhosphoSitePlus
N221 N-Glycosylation GlyGen   UniProt 10066782, 28060820
S243 Phosphorylation PhosphoSitePlus
N245 N-Glycosylation GlyGen   UniProt 28060820
T329 O-Glycosylation GlyGen 30459171
T335 O-Glycosylation GlyGen 30459171
N350 N-Glycosylation GlyGen   UniProt 28060820
T352 O-Glycosylation GlyGen   UniProt 28060820
K401 Ubiquitination PhosphoSitePlus
S455 Phosphorylation PhosphoSitePlus
Y457 Phosphorylation PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T139 I139 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S141 F141 Biomuta DOID:4159 / skin cancer [ icgc ]
S141 Y141 Biomuta DOID:3571 / liver cancer [ cosmic ]
S243 Y243 Biomuta DOID:4159 / skin cancer [ cosmic ]
K401 N401 Biomuta DOID:4159 / skin cancer [ cosmic ]
K401 M401 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y457 D457 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]