Protein Information

Cytoscape View


UniProt AC / UniProt ID P08754 / GNAI3_HUMAN
Protein Name Guanine nucleotide-binding protein G(i) subunit alpha
Gene Name Name: GNAI3
Organism Homo sapiens (Human)

PRO ID PR:P08754
DAG View
PRO Name guanine nucleotide-binding protein G(i) subunit alpha (human)
Definition A guanine nucleotide-binding protein G(i) subunit alpha that is encoded in the genome of human.
Short Label hGNAI3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08754 (GNAI3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805
K17 Ubiquitination PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
K46 Ubiquitination PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus
K67 Ubiquitination PhosphoSitePlus
Y69 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K70 Acetylation PhosphoSitePlus
K92 Sumoylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K128 Ubiquitination PhosphoSitePlus
R144 Methylation PhosphoSitePlus
R161 Methylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
Y167 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
K248 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K317 Ubiquitination PhosphoSitePlus
Y320 Phosphorylation PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K46 E46 Biomuta DOID:363 / uterine cancer [ tcga ]
Y69 * Biomuta DOID:1793 / pancreatic cancer [ icgc ]
R161 K161 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S163 A163 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K197 N197 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K349 Q349 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]