Protein Information

Cytoscape View


UniProt AC / UniProt ID P08670 / VIME_HUMAN
Protein Name Vimentin
Gene Name Name: VIM
Organism Homo sapiens (Human)

PRO ID PR:P08670
DAG View
PRO Name vimentin (human)
Definition A vimentin that is encoded in the genome of human.
Short Label hVIM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08670 (VIM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD   RLIMS-P 20068231, 24282534
T3 Phosphorylation PhosphoSitePlus
R4 Methylation PhosphoSitePlus
S5 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14762106, 18669648, 20068231
S7 O-Glycosylation PhosphoSitePlus   UniProt 20068230
S7 Phosphorylation P17252 (PRKCA) , Q96GD4 (AURKB) , Q02156 (PRKCE) , P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 14762106, 18212344, 19664995, ...18669648, 12458200, 2500966, 20068231, 16270034
S8 Phosphorylation P17252 (PRKCA) PhosphoSitePlus   UniProt 14762106
S9 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   UniProt 14762106, 2500966, 19664995, ...20068231
S10 Phosphorylation P17252 (PRKCA) HPRD   PhosphoSitePlus   UniProt 14762106, 2500966, 20068231
Y11 Phosphorylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus
R13 Methylation PhosphoSitePlus
T20 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17287340, 19007248, 19691289, ...24275569, 20068231
S22 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17287340, 20068231
R23 Methylation PhosphoSitePlus
S25 Phosphorylation Q96GD4 (AURKB) , P17252 (PRKCA) , P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 12458200, 19691289, ...18669648, 24275569, 17287340, 2500966, 20068231
S26 Phosphorylation Q13153 (PAK1) , P17252 (PRKCA) , Q13177 (PAK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340, 11895474, ...2500966, 20068231
S27 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17287340, 17081983, 20068231
R28 Methylation PhosphoSitePlus
S29 Phosphorylation HPRD   PhosphoSitePlus 18212344, 20068231, 19007248
Y30 Phosphorylation HPRD   PhosphoSitePlus 17081983
T32 Phosphorylation HPRD   PhosphoSitePlus 19691289
T33 O-Glycosylation PhosphoSitePlus   UniProt 20068230
T33 Phosphorylation HPRD   PhosphoSitePlus 19007248, 19691289, 17081983
S34 O-Glycosylation PhosphoSitePlus   UniProt 20068230
S34 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 2500966, 18212344, ...20068231
T35 Phosphorylation PhosphoSitePlus
R36 Methylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
Y38 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S39 Phosphorylation P49137 (MAPKAPK2) , Q13177 (PAK2) , P17612 (PRKACA) , P31749 (AKT1) , O75116 (ROCK2) , Q13153 (PAK1) , Q96GD4 (AURKB) , P17252 (PRKCA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12761892, 23186163, 20856200, ...19691289, 12458200, 24275569, 30696956, 18220336, 18767875, 29781749, 21969470, 19007248, 9565595, 14762106, 17287340, 17024653, 18669648, 11895474, 2500966, 20068231, 20058876
S42 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14762106, 23186163, 18220336, ...19691289, 19007248, 18669648, 2500966, 19415658, 20068231
R45 Methylation PhosphoSitePlus
S47 Phosphorylation P17612 (PRKACA) , Q96GD4 (AURKB) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 17287340, 12458200, 18669648, ...23186163, 2500966, 20068231
T48 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 18220336
S49 Phosphorylation PhosphoSitePlus   UniProt 23186163
R50 Methylation PhosphoSitePlus
S51 Phosphorylation Q13153 (PAK1) , P49137 (MAPKAPK2) , Q13177 (PAK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18212344, ...18220336, 15713670, 19664995, 19691289, 12761892, 18669648, 11895474, 19007248, 19690332, 20068231
Y53 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 19901323, 18578522, 19664995, ...18083107, 18669648, 18707149, 30696956, 20068231, 16497976
S55 O-Glycosylation PhosphoSitePlus
S55 Phosphorylation P06493 (CDK1) , P24941 (CDK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 18691976, 18491316, 17287340, ...12691412, 7983050, 18847512, 19664995, 27603133, 19651622, 18669648, 9030781, 9168797, 19584300, 9378721, 16260496, 25375189, 2019567, 12686602, 20068231
S56 Phosphorylation P78527 (PRKDC) , P06493 (CDK1) , P49137 (MAPKAPK2) , Q13153 (PAK1) , P24941 (CDK2) , Q00535 (CDK5) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 19413330, 18578522, 16964243, ...12761892, 21465480, 16990256, 27603133, 18707149, 30267961, 18691976, 23186163, 18212344, 16997882, 7983050, 15766329, 30135525, 19691289, 16565220, 15345747, 19690332, 19812368, 18767875, 18847512, 20058876, 19007248, 19494238, 19270731, 19651622, 18491316, 17287340, 17081983, 24282534, 15713670, 19664995, 18669648, 20068230, 19415658, 20068231, 17924679
Y61 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19901323, 18578522, 18491316, ...17287340, 18212344, 20230923, 18083107, 30696956, 18669648, 18707149, 15592455, 23186163, 19690332, 20068231, 16497976
T63 Phosphorylation PhosphoSitePlus
R64 Methylation PhosphoSitePlus
S65 Phosphorylation Q96GD4 (AURKB) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 18669648, 12458200, 20068231
S66 Phosphorylation Q96GD4 (AURKB) , Q13153 (PAK1) , Q13177 (PAK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 12458200, 18669648, ...11895474, 20068231
R69 Methylation PhosphoSitePlus
R71 Methylation PhosphoSitePlus
S72 Phosphorylation Q96GD4 (AURKB) , Q13464 (ROCK1) , P17612 (PRKACA) , O75116 (ROCK2) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 14762106, 11420699, 15676024, ...21969470, 18669648, 15597762, 12553669, 20166139, 12458200, 9565595, 30696956, 19007248, 23737341, 20068231
S73 Phosphorylation Q13177 (PAK2) , Q96GD4 (AURKB) , P17612 (PRKACA) , Q13153 (PAK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 14762106, 18578522, 23186163, ...17081983, 15676024, 11420699, 12458200, 19007248, 14722118, 20166139, 18669648, 19651622, 30696956, 11895474, 20068231
S83 Phosphorylation Q13557 (CAMK2D) , Q9UQM7 (CAMK2A) , P49137 (MAPKAPK2) , P53350 (PLK1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9794428, 18056432, 16140754, ...12761892, 29107103, 18669648, 10852918, 24275569, 20166139, 15345747, 20068231
S87 Phosphorylation Q96GD4 (AURKB) HPRD   neXtProt   PhosphoSitePlus   UniProt 12458200, 24275569, 20068231
K97 Ubiquitination PhosphoSitePlus
T99 Phosphorylation HPRD   PhosphoSitePlus 20068231
T101 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
R113 Methylation PhosphoSitePlus
Y117 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 15592455, 30696956
K120 Acetylation PhosphoSitePlus   UniProt 19608861
K120 Methylation PhosphoSitePlus
K120 Ubiquitination PhosphoSitePlus
K129 Acetylation PhosphoSitePlus
K129 Ubiquitination PhosphoSitePlus
K139 Acetylation PhosphoSitePlus   UniProt 19608861
K139 Ubiquitination PhosphoSitePlus
K143 Ubiquitination PhosphoSitePlus
S144 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 21406692, 20068231
Y150 Phosphorylation PhosphoSitePlus
R158 Methylation PhosphoSitePlus
K168 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
R184 Methylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
S205 Phosphorylation HPRD   PhosphoSitePlus 20068231
S214 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 19007248, ...19691289, 24275569, 18707149, 20068231
K223 Ubiquitination PhosphoSitePlus
S226 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K235 Acetylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K236 Acetylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
S261 Phosphorylation HPRD   PhosphoSitePlus 19007248, 20068231
K262 Ubiquitination PhosphoSitePlus
T266 Phosphorylation HPRD   PhosphoSitePlus 19007248
Y276 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
K282 Acetylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
K292 Acetylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S299 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19007248, ...20068231
R310 Methylation PhosphoSitePlus
K313 Acetylation PhosphoSitePlus
K313 Sumoylation PhosphoSitePlus
K313 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S325 Phosphorylation HPRD   PhosphoSitePlus 18578522, 19664995, 20068231, ...18452278
T327 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 20068231, 18452278
C328 S-Nitrosylation dbSNO 19447776, 19483679, 26338901, ...25040305, 22126794, 22178444
K334 Acetylation PhosphoSitePlus
K334 Ubiquitination PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus
Y358 Phosphorylation PhosphoSitePlus
T361 Phosphorylation PhosphoSitePlus
K373 Acetylation PhosphoSitePlus   UniProt 19608861
K373 Ubiquitination PhosphoSitePlus
R381 Methylation PhosphoSitePlus
Y383 Phosphorylation PhosphoSitePlus
Y400 Phosphorylation HPRD 18083107
R401 Methylation PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K402 Sumoylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S409 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
R410 Methylation PhosphoSitePlus
S412 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17081983, 18220336, ...19651622, 18669648, 20068231, 17924679
S419 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18578522, 23186163, 17081983, ...20230923, 20058876, 19651622, 18669648, 24275569, 20166139, 20068231
S420 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14762106, 18578522, 23186163, ...20230923, 20058876, 19651622, 18669648, 20166139, 20068231
T426 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15274135, 17081983, 18578522, ...19691289, 24275569, 20068231
S430 Phosphorylation P78527 (PRKDC) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14762106, 18578522, 17287340, ...17081983, 24282534, 19691289, 18669648, 24275569, 23186163, 20068231
T436 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18578522, 23186163, 20068231
S438 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18578522, 23186163, 20068231
K439 Acetylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
T441 Phosphorylation PhosphoSitePlus
K445 Acetylation PhosphoSitePlus   UniProt 19608861
K445 Methylation PhosphoSitePlus
K445 Sumoylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
T446 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 17924679
T449 Phosphorylation PhosphoSitePlus
T458 Phosphorylation P00540 (MOS) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 14762106, 17287340, 17081983, ...18767875, 19664995, 19651622, 20068231
S459 Phosphorylation P78527 (PRKDC) , P53350 (PLK1) , P00540 (MOS) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 19413330, 18691976, 21406692, ...17287340, 17081983, 14762106, 18767875, 19651622, 19007248, 19664995, 17322306, 24196446, 18669648, 20166139, 23186163, 24282534, 19415658, 20068231, 17924679


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P08670 (VIM) S55 P53350 (PLK1) unknown eFIP 16260496
Phosphorylation Q05397 (PTK2) Y397 P08670 (VIM) unknown eFIP 24858039


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 L8 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S22 I22 Biomuta DOID:3571 / liver cancer [ tcga ]
T33 M33 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
R50 H50 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S55 A55 Biomuta DOID:1324 / lung cancer [ cosmic ]
S56 Y56 Biomuta DOID:1324 / lung cancer [ cosmic ]
R64 H64 Biomuta DOID:1909 / melanoma [ cosmic ]
R69 C69 Biomuta DOID:1909 / melanoma [ cosmic ]
R71 W71 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K129 E129 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R158 H158 Biomuta DOID:363 / uterine cancer [ icgc ]
T266 M266 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:10534 / stomach cancer [ tcga ]
S278 R278 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R310 H310 Biomuta DOID:10283 / prostate cancer [ cosmic ]
R310 S310 Biomuta DOID:363 / uterine cancer [ tcga ]
R310 C310 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:10534 / stomach cancer [ cosmic ]
Y319 C319 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S325 Y325 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S325 P325 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
S325 F325 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S339 F339 Biomuta DOID:1909 / melanoma [ tcga ]
R381 G381 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y400 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S412 Y412 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S412 P412 Biomuta DOID:363 / uterine cancer [ tcga ]
S420 F420 Biomuta DOID:1909 / melanoma [ tcga ]
S438 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T446 R446 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S459 C459 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]