iPTMnet Report for P08631 (HCK)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08631 / HCK_HUMAN
Protein Name Tyrosine-protein kinase HCK
Gene Name Name: HCK
Organism Homo sapiens (Human)

PRO ID PR:P08631
DAG View
PRO Name tyrosine-protein kinase HCK (human)
Definition A tyrosine-protein kinase HCK that is encoded in the genome of human.
Short Label hHCK
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08631 (HCK) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 7791757
K28 Ubiquitination PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y51 Phosphorylation neXtProt   PhosphoSitePlus   Signor   UniProt 10934191, 11896602
Y51 Phosphorylation P08631 (HCK) neXtProt   Signor   UniProt 10934191, 11896602
Y89 Phosphorylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus
S119 Phosphorylation PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
Y180 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y209 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107, 10644735
Y209 Phosphorylation P08631 (HCK) phospho.ELM 10644735
K228 Acetylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
Y330 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
S347 O-Glycosylation GlyGen 29351928
S351 O-Glycosylation GlyGen 29351928
Y411 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11896602, 10644735, 10934191, ...9822689
Y411 Phosphorylation P08631 (HCK) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10934191, 9822689, 10644735
T412 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus   UniProt 19369195
S520 Phosphorylation PhosphoSitePlus
Y522 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor   UniProt 10360180, 11896602, 10644735, ...16216497, 14985335, 10934191, 9024658
Y522 Phosphorylation P08631 (HCK) phospho.ELM   PhosphoSitePlus   Signor 10934191, 10644735
Y522 Phosphorylation P42679 (MATK) neXtProt 14985335
Site PTM Type PTM Enzyme Score Source PMID
Y51 Phosphorylation HPRD 10934191
Y51 Phosphorylation P08631 (HCK) HPRD 10934191
Y209 Phosphorylation HPRD 18083107, 16497976
Y411 Phosphorylation HPRD 17016520, 16497976, 11976726, ...19664994, 9407116
Y411 Phosphorylation P08631 (HCK) HPRD 17016520, 16497976, 11976726, ...19664994, 9407116
Y522 Phosphorylation HPRD 11976726
Y522 Phosphorylation P41240 (CSK) HPRD 11976726


P08631 (HCK) as PTM Enzyme



Substrate Site Score Source PMID
O15350 (TP73) Y28 neXtProt 17535448
O60496 (DOK2) Y271 HPRD 10428862
O60496 (DOK2) Y299 HPRD 19901323, 10428862, 16497976
O60496 (DOK2) Y345 HPRD 10428862
P00519 (ABL1) Y70 neXtProt   PhosphoSitePlus 18775435, 16912036
P00519 (ABL1) Y115 PhosphoSitePlus 16912036
P00519 (ABL1) Y128 PhosphoSitePlus 16912036
P00519 (ABL1) Y139 PhosphoSitePlus 16912036
P00519 (ABL1) Y172 PhosphoSitePlus 16912036
P00519 (ABL1) Y185 PhosphoSitePlus 16912036
P00519 (ABL1) Y215 PhosphoSitePlus 16912036
P00519 (ABL1) Y226 PhosphoSitePlus 18775435, 16912036
P00519 (ABL1) Y393 PhosphoSitePlus 18775435, 16912036
P08631-1 (HCK) Y51 HPRD   neXtProt   Signor   UniProt 10934191, 11896602
P08631 (HCK) Y209 phospho.ELM 10644735
P08631 (HCK) Y411 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 17016520, 9822689, 11976726, ...9407116, 10644735, 19664994, 10934191, 16497976
P08631 (HCK) Y522 phospho.ELM   PhosphoSitePlus   Signor 10934191, 10644735
P11274 (BCR) Y177 HPRD   phospho.ELM   PhosphoSitePlus 9407116, 9178913, 8955135, ...12522270, 16912036, 16497976
P16885 (PLCG2) Y753 HPRD 7682059, 12181444, 15144186
P16885 (PLCG2) Y759 HPRD 19901323, 7682059, 12181444, ...16497976
P19174-1 (PLCG1) Y771 HPRD 17016520, 17389395, 7682059, ...15144186, 8657103, 1689310, 20068231, 16497976
P19174-2 (PLCG1) Y783 HPRD 17016520, 17389395, 7682059, ...8657103, 20068231, 1689310, 8885868, 16497976
P19174-1 (PLCG1) Y1253 HPRD 17016520, 17389395, 7682059, ...15144186, 20068231, 18707149, 8885868
P22681 (CBL) Y731 HPRD 11994282, 10092522, 9890970, ...11239464, 10799548
P40763-2 (STAT3) Y704 HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095
P40763-1 (STAT3) Y705 HPRD 17016520, 19901323, 10918587, ...12576423, 8626374, 11350938, 14551213, 17389395, 12626508, 11294897, 11940572, 12244095, 16497976
P42229 (STAT5A) Y694 PhosphoSitePlus 25885255
P42768 (WAS) Y291 HPRD   phospho.ELM 19901323, 18088087, 12769846, ...10068673, 9742969, 12235133, 16497976
P51692 (STAT5B) Y699 phospho.ELM   PhosphoSitePlus 12411494
Q05655 (PRKCD) Y313 neXtProt 20190138
Q13444 (ADAM15) Y715 phospho.ELM   PhosphoSitePlus   Signor 11741929
Q13444 (ADAM15) Y735 Signor 11741929
Q13905 (RAPGEF1) Y504 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10318861, 24396067, 15320955, ...12734187, 14551197
Q13905-3 (RAPGEF1) Y522 HPRD 10318861, 12734187, 14551197
Q92556 (ELMO1) Y18 HPRD   neXtProt   PhosphoSitePlus   Signor 12029088, 15952790
Q92556-2 (ELMO1) Y31 HPRD 15952790
Q92556 (ELMO1) Y216 HPRD   neXtProt   PhosphoSitePlus   Signor 12029088, 15952790
Q92556-2 (ELMO1) Y240 HPRD 15952790
Q92556 (ELMO1) Y395 HPRD   neXtProt   PhosphoSitePlus   Signor 12029088, 15952790
Q92556 (ELMO1) Y511 HPRD   neXtProt   PhosphoSitePlus   Signor 12029088, 15952790
Q92556 (ELMO1) Y720 HPRD   neXtProt   PhosphoSitePlus   Signor 12029088, 15952790
Q99062-1 (CSF3R) Y752 HPRD 9790917
Q99062-3 (CSF3R) Y779 HPRD 9790917
Q99062-1 (CSF3R) Y787 HPRD 9790917
Q99062-3 (CSF3R) Y814 HPRD 9790917
Q9UQC2 (GAB2) Y452 neXtProt 17513616


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000025889 (hHCK/Phos:1) pY522 PRO 10360180


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K28 T28 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T36 I36 Biomuta DOID:1324 / lung cancer [ cosmic ]
S111 F111 Biomuta DOID:4159 / skin cancer [ cosmic ]
K124 N124 Biomuta DOID:4159 / skin cancer [ cosmic ]
S181 P181 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S181 F181 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y209 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S261 Y261 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S261 F261 Biomuta DOID:4159 / skin cancer [ cosmic ]
T311 S311 Biomuta DOID:3571 / liver cancer [ cosmic ]
T311 I311 Biomuta [ cosmic ]
Y330 H330 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
Y411 C411 Biomuta DOID:363 / uterine cancer [ icgc ]
T412 M412 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10283 / prostate cancer [ cosmic, icgc ]
T412 K412 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S442 F442 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y522 * Biomuta DOID:1324 / lung cancer [ cosmic ]