iPTMnet Report for P08581 (MET)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08581 / MET_HUMAN
Protein Name Hepatocyte growth factor receptor precursor
Gene Name Name: MET
Organism Homo sapiens (Human)

PRO ID PR:P08581
DAG View
PRO Name hepatocyte growth factor receptor (human)
Definition A hepatocyte growth factor receptor that is encoded in the genome of human.
Short Label hMET
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08581 (MET) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T17 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
N106 N-Glycosylation GlyGen   UniProt 23090970, 19196183, 29391424, ...24190977
N149 N-Glycosylation GlyGen 24190977
S178 Phosphorylation RLIMS-P 25778903
K189 Ubiquitination PhosphoSitePlus
N199 N-Glycosylation GlyGen 24190977
K223 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
N393 N-Glycosylation GlyGen 24190977
N399 N-Glycosylation GlyGen 23090970, 24190977
N405 N-Glycosylation GlyGen 23345538
S468 Phosphorylation PhosphoSitePlus
S473 Phosphorylation RLIMS-P 19240370
T582 O-Glycosylation UniProt 37186866
N607 N-Glycosylation GlyGen 23090970, 24190977
S637 Phosphorylation PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus
T676 O-Glycosylation UniProt 37186866
K725 Ubiquitination PhosphoSitePlus
Y745 Phosphorylation PhosphoSitePlus
T750 Phosphorylation PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
S758 Phosphorylation PhosphoSitePlus
T759 Phosphorylation PhosphoSitePlus
T761 O-Glycosylation UniProt 37186866
K765 Ubiquitination PhosphoSitePlus
N785 N-Glycosylation GlyGen 23090970, 29391424, 24190977
T787 O-Glycosylation GlyGen 34019948, 35289036
Y830 Phosphorylation phospho.ELM   PhosphoSitePlus 12746450
K876 Ubiquitination PhosphoSitePlus
T918 O-Glycosylation GlyGen 25813380
N930 N-Glycosylation GlyGen 23345538
K962 Ubiquitination PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y971 Phosphorylation PhosphoSitePlus
T977 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 17192257
S985 Phosphorylation Q02156 (PRKCE) , P17252 (PRKCA) , Q05655 (PRKCD) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 7925482, 8294430, 15075332, ...24634221, 27147579
S988 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17192257
S990 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17192257
T992 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T993 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S997 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
N998 N-Glycosylation GlyGen 29671580, 29391424
S1000 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Y1003 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 19369195, 24362531, ...21283737, 22973954, 32782246, 23624790, 24634221, 17192257, 18083107, 30309648, 19240370, 11741535, 24330766, 21163258
T1006 Phosphorylation PhosphoSitePlus
S1015 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation PhosphoSitePlus
S1020 Phosphorylation PhosphoSitePlus
Y1026 Phosphorylation PhosphoSitePlus
Y1093 Phosphorylation PhosphoSitePlus
T1096 Phosphorylation PhosphoSitePlus
K1103 Ubiquitination PhosphoSitePlus
K1104 Ubiquitination PhosphoSitePlus
K1110 Ubiquitination PhosphoSitePlus
Y1159 Phosphorylation PhosphoSitePlus
K1161 Ubiquitination PhosphoSitePlus
N1171 N-Glycosylation GlyGen 29391424
K1179 Ubiquitination PhosphoSitePlus
K1190 Acetylation PhosphoSitePlus
K1190 Ubiquitination PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
Y1194 Phosphorylation PhosphoSitePlus
K1199 Ubiquitination PhosphoSitePlus
K1215 Ubiquitination PhosphoSitePlus
K1219 Ubiquitination PhosphoSitePlus
Y1230 Phosphorylation P08581 (MET) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 27191264, 12475979, 21423210, ...20145145, 18083107, 19240370, 31072019, 20085644, 21119598, 28332364
K1232 Ubiquitination PhosphoSitePlus
Y1234 Phosphorylation P08581 (MET) , Q04912 (MST1R) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32650779, 21992464, 32782246, ...7961992, 20085644, 23866081, 16101282, 21119598, 16914575, 31440058, 20623641, 12475979, 30999598, 21423210, 31072019, 22511956, 28332364, 26801760, 1247597, 23968581, 28248267, 21247903, 8302603, 20145145, 32565941, 29254183, 8547236, 24634221, 26216473, 26252654, 30638462, 25607934, 27323832, 18083107, 24362531, 19240370, 10871856, 8208547, 27147579
Y1235 Phosphorylation P08581 (MET) , Q04912 (MST1R) , P51813 (BMX) IntAct   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 32650779, 21992464, 22745804, ...32782246, 7961992, 20085644, 16101282, 21119598, 16914575, 31440058, 20623641, 27191264, 12475979, 30999598, 21423210, 31072019, 22511956, 1655790, 28332364, 26801760, 1247597, 23968581, 28248267, 21247903, 8302603, 32565941, 24634221, 20145145, 29254183, 26252654, 30638462, 8547236, 27323832, 23716717, 18083107, 24362531, 19240370, 10871856, 8208547
S1236 Phosphorylation PhosphoSitePlus
K1240 Ubiquitination PhosphoSitePlus
T1241 Phosphorylation PhosphoSitePlus
K1244 Ubiquitination PhosphoSitePlus
K1248 Ubiquitination PhosphoSitePlus
K1259 Ubiquitination PhosphoSitePlus
T1289 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y1307 Phosphorylation PhosphoSitePlus
Y1313 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 10069803, 24634221, 21777671, ...23583448, 7708691
K1318 Ubiquitination PhosphoSitePlus
S1342 Phosphorylation PhosphoSitePlus
T1343 Phosphorylation PhosphoSitePlus
Y1349 Phosphorylation P00519 (ABL1) , Q04912 (MST1R) , P08581 (MET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 26259250, 7513258, 22745804, ...32782246, 9826708, 18779368, 20432459, 21777671, 16782899, 26436697, 16914575, 28332364, 19187270, 12475979, 7731718, 21734462, 32565941, 24634221, 26215852, 18046719, 23583448, 20145145, 9444958, 21283737, 9252406, 27191264, 18930356, 24362531, 10871856, 7687741
T1355 Phosphorylation PhosphoSitePlus
Y1356 Phosphorylation P00519 (ABL1) , Q04912 (MST1R) , P08581 (MET) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12475979, 7513258, 7961992, ...7687741, 30165040, 32782246, 9252406, 9826708, 8547236, 21777671, 23583448, 10871856, 16782899, 9444958, 15735664, 8662889, 7731718
Y1365 Phosphorylation P08581 (MET) IntAct   phospho.ELM   PhosphoSitePlus   UniProt 12475979, 16101282, 20145145
S1367 Phosphorylation PhosphoSitePlus
S1370 Phosphorylation PhosphoSitePlus
S1371 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N405 N-Glycosylation PRO 23345538
N930 N-Glycosylation PRO 23345538
S966 Phosphorylation HPRD 18691976
T977 Phosphorylation P08581 (MET) HPRD 18691976, 17192257, 20068231
S985 Phosphorylation HPRD 8294430
S988 Phosphorylation P08581 (MET) HPRD 18691976, 18669648, 17192257, ...20068231, 18452278
S990 Phosphorylation P08581 (MET) HPRD 18691976, 18669648, 17192257, ...18452278
T992 Phosphorylation HPRD 18669648
T993 Phosphorylation HPRD 18669648
S997 Phosphorylation HPRD 18691976, 18669648
N998 N-Glycosylation PRO 29671580
S1000 Phosphorylation HPRD 18691976, 18669648, 17081983
Y1003 Phosphorylation HPRD 18691976, 11741535
Y1230 Phosphorylation HPRD 17016520, 12475979
Y1234 Phosphorylation HPRD 17016520, 8302603, 7961992
Y1235 Phosphorylation HPRD 12475979
Y1295 Phosphorylation HPRD 10069803, 7708691
S1331 Phosphorylation HPRD 12475979, 9444958, 7731718, ...7513258, 9252406
S1338 Phosphorylation HPRD 12475979, 9444958, 7731718, ...7513258, 9252406
Y1349 Phosphorylation HPRD 10069803, 12475979, 7708691
Y1356 Phosphorylation HPRD 10069803, 7961992, 7708691
Y1365 Phosphorylation HPRD 12475979


P08581 (MET) as PTM Enzyme



Substrate Site Score Source PMID
P08581-1 (MET) T977 HPRD 18691976, 17192257, 20068231
P08581-1 (MET) S988 HPRD 18691976, 18669648, 17192257, ...20068231, 18452278
P08581-1 (MET) S990 HPRD 18691976, 18669648, 17192257, ...18452278
P08581 (MET) Y1230 phospho.ELM   PhosphoSitePlus 12475979, 20145145
P08581 (MET) Y1234 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 1247597, 12475979, 8302603, ...20145145, 8547236, 7961992, 8208547
P08581 (MET) Y1235 neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12475979, 8302603, 20145145, ...8547236, 7961992, 1655790, 8208547
P08581 (MET) Y1349 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 16782899, 7687741, 12475979, ...7731718, 20145145
P08581 (MET) Y1356 neXtProt   phospho.ELM   PhosphoSitePlus   UniProt 15735664, 7687741, 8547236, ...7961992, 16782899, 7731718
P08581 (MET) Y1365 PhosphoSitePlus 20145145
P09874 (PARP1) Y907 PhosphoSitePlus 26779812
P29353 (SHC1) Y427 neXtProt   PhosphoSitePlus 7731718
Q04912 (MST1R) Y1238 PhosphoSitePlus 10871856
Q04912 (MST1R) Y1239 PhosphoSitePlus 10871856
Q04912 (MST1R) Y1353 PhosphoSitePlus 10871856
Q04912 (MST1R) Y1360 PhosphoSitePlus 10871856
Q05397 (PTK2) Y5 neXtProt   PhosphoSitePlus 20802513
Q05397 (PTK2) Y194 neXtProt   PhosphoSitePlus   Signor 16782899, 20802513
Q05397 (PTK2) Y397 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y407 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y576 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y577 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y861 neXtProt   PhosphoSitePlus   Signor 16782899
Q05397 (PTK2) Y925 neXtProt   PhosphoSitePlus   Signor 16782899
Q13480 (GAB1) Y285 HPRD   neXtProt   phospho.ELM   Signor 10734310
Q13480 (GAB1) Y307 HPRD   neXtProt   phospho.ELM 10734310, 16497976
Q13480-2 (GAB1) Y373 HPRD   neXtProt   phospho.ELM 10978177, 10734310, 17389395, ...16497976
Q13480-2 (GAB1) Y406 HPRD   neXtProt   phospho.ELM 17016520, 10734310, 17389395, ...19901323, 16497976
Q13480 (GAB1) Y447 HPRD   neXtProt   phospho.ELM 10734310
Q13480-2 (GAB1) Y472 HPRD   neXtProt   phospho.ELM 10734310
Q13480 (GAB1) Y589 HPRD   neXtProt   phospho.ELM   Signor 10734310
Q13480-2 (GAB1) Y619 HPRD 10734310
Q13480 (GAB1) Y627 HPRD   neXtProt   phospho.ELM   Signor 17016520, 10734310, 17389395, ...20068231
Q13480-2 (GAB1) Y657 HPRD 17016520, 10734310, 17389395, ...20068231
Q13480-1 (GAB1) Y659 HPRD   neXtProt   phospho.ELM   Signor 10734310, 18669648, 17389395, ...16497976
Q13480-2 (GAB1) Y689 HPRD 10734310, 18669648, 17389395, ...16497976


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P08581 (MET) Y1356 O15357 (INPPL1) unknown eFIP 30165040
Phosphorylation P08581 (MET) Y1349 Q13480 (GAB1) increased_association eFIP 18046719


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N106 D106 Biomuta DOID:3571 / liver cancer [ cosmic ]
N149 K149 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N149 S149 Biomuta DOID:3571 / liver cancer [ cosmic ]
N149 T149 Biomuta [ cosmic ]
N393 K393 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
N393 S393 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N399 I399 Biomuta DOID:4159 / skin cancer [ cosmic ]
S468 Y468 Biomuta DOID:1324 / lung cancer [ cosmic ]
T582 I582 Biomuta DOID:4159 / skin cancer [ cosmic ]
S641 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T676 I676 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K751 I751 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T787 A787 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
Y971 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y971 C971 Biomuta DOID:1324 / lung cancer [ cosmic ]
T992 I992 Biomuta [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:184 / bone cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:3953 / adrenal gland cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
T993 A993 Biomuta DOID:1324 / lung cancer [ cosmic ]
S997 L997 Biomuta [ cosmic ]
N998 D998 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1000 T1000 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1000 F1000 Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y1003 N1003 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1003 F1003 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1003 C1003 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1003 S1003 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y1003 * Biomuta DOID:1324 / lung cancer [ cosmic ]
T1006 I1006 Biomuta DOID:1319 / brain cancer [ cosmic ]
S1020 T1020 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S1020 P1020 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y1093 N1093 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1096 S1096 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K1104 I1104 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1179 E1179 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y1194 F1194 Biomuta DOID:1319 / brain cancer [ cosmic ]
K1199 T1199 Biomuta DOID:363 / uterine cancer [ icgc ]
Y1230 C1230 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
Y1230 S1230 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y1230 H1230 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
Y1235 H1235 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y1235 D1235 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S1236 R1236 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K1244 R1244 Biomuta DOID:3571 / liver cancer [ cosmic ]
T1289 I1289 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K1318 E1318 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y1356 C1356 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1365 F1365 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S1367 Y1367 Biomuta DOID:1319 / brain cancer [ icgc ]