iPTMnet Report for P08575 (PTPRC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08575 / PTPRC_HUMAN
Protein Name Receptor-type tyrosine-protein phosphatase C precursor
Gene Name Name: PTPRC
Synonyms:CD45;
Organism Homo sapiens (Human)

PRO ID PR:P08575
DAG View
PRO Name receptor-type tyrosine-protein phosphatase C (human)
Definition A receptor-type tyrosine-protein phosphatase C that is encoded in the genome of human.
Short Label hPTPRC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08575 (PTPRC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T167 O-Glycosylation GlyGen 30459171
S176 O-Glycosylation GlyGen 30459171
S185 O-Glycosylation GlyGen 27655845, 34931806, 21300897, ...35132862, 29351928
T187 O-Glycosylation GlyGen 27655845, 34931806, 21300897, ...35132862, 29351928
T193 O-Glycosylation GlyGen 27655845, 34931806, 21300897, ...35132862, 29351928
S194 O-Glycosylation GlyGen 27655845, 34931806, 21300897, ...35132862, 29351928
N199 N-Glycosylation GlyGen 24190977
N234 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 29391424, ...19349973, 30582698, 29741879
N255 N-Glycosylation GlyGen 24190977
N257 N-Glycosylation GlyGen 24190977
N262 N-Glycosylation GlyGen 24190977
N263 N-Glycosylation GlyGen 24190977
N267 N-Glycosylation GlyGen 24190977
N268 N-Glycosylation GlyGen 24190977
N272 N-Glycosylation GlyGen 24190977
N278 N-Glycosylation GlyGen   UniProt 24190977, 30582698, 29391424, ...19349973
S280 Phosphorylation PhosphoSitePlus
N286 N-Glycosylation GlyGen   UniProt 24190977, 19349973
K316 Ubiquitination PhosphoSitePlus
N327 N-Glycosylation GlyGen 24211831, 24190977
N337 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 29391424, ...19349973, 30582698, 29741879, 29671580
K352 Ubiquitination PhosphoSitePlus
K355 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
N374 N-Glycosylation GlyGen 24190977
N375 N-Glycosylation GlyGen 24190977
N380 N-Glycosylation GlyGen 29741879, 30582698, 29391424, ...24190977
K383 Ubiquitination PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
N421 N-Glycosylation GlyGen   UniProt 29741879, 19349973, 30582698, ...24190977
K439 Acetylation PhosphoSitePlus
K439 Ubiquitination PhosphoSitePlus
N440 N-Glycosylation GlyGen 24190977
K450 Ubiquitination PhosphoSitePlus
Y455 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
N470 N-Glycosylation GlyGen 29741879, 30582698, 29391424, ...24190977
N490 N-Glycosylation GlyGen   UniProt 29741879, 24190977, 29391424, ...19349973
N499 N-Glycosylation GlyGen 24190977
N526 N-Glycosylation GlyGen 24190977
N531 N-Glycosylation GlyGen 24190977
N536 N-Glycosylation GlyGen 24190977
K542 Ubiquitination PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
Y550 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation PhosphoSitePlus
K643 Ubiquitination PhosphoSitePlus
S659 Phosphorylation PhosphoSitePlus
S665 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
K670 Ubiquitination PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
Y689 Phosphorylation PhosphoSitePlus
Y691 Phosphorylation PhosphoSitePlus
Y707 Phosphorylation PhosphoSitePlus
Y712 Phosphorylation PhosphoSitePlus
K717 Ubiquitination PhosphoSitePlus
K721 Ubiquitination PhosphoSitePlus
T746 Phosphorylation IEDB 35494241
K761 Ubiquitination PhosphoSitePlus
Y765 Phosphorylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
Y792 Phosphorylation PhosphoSitePlus
K796 Ubiquitination PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
K833 Ubiquitination PhosphoSitePlus
T860 Phosphorylation PhosphoSitePlus
T862 Phosphorylation PhosphoSitePlus
Y863 Phosphorylation PhosphoSitePlus
Y882 Phosphorylation PhosphoSitePlus
Y902 Phosphorylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
S939 Phosphorylation PhosphoSitePlus
S953 Phosphorylation PhosphoSitePlus
K969 Ubiquitination PhosphoSitePlus
S975 Phosphorylation PhosphoSitePlus   UniProt 19367720, 23186163, 19690332
Y980 Phosphorylation PhosphoSitePlus
Y982 Phosphorylation PhosphoSitePlus
K988 Ubiquitination PhosphoSitePlus
S994 Phosphorylation PhosphoSitePlus   UniProt 23186163
S997 Phosphorylation PhosphoSitePlus
S1001 Phosphorylation PhosphoSitePlus   Signor 10066810
S1001 Phosphorylation P19784 (CSNK2A2) Signor 10066810
S1001 Phosphorylation P68400 (CSNK2A1) Signor 10066810
S1004 Phosphorylation PhosphoSitePlus   Signor 10066810
S1004 Phosphorylation P19784 (CSNK2A2) Signor 10066810
S1004 Phosphorylation P68400 (CSNK2A1) Signor 10066810
S1005 Phosphorylation PhosphoSitePlus   Signor 10066810
S1005 Phosphorylation P19784 (CSNK2A2) Signor 10066810
S1005 Phosphorylation P68400 (CSNK2A1) Signor 10066810
S1009 Phosphorylation PhosphoSitePlus   Signor 10066810
S1009 Phosphorylation P19784 (CSNK2A2) Signor 10066810
S1009 Phosphorylation P68400 (CSNK2A1) Signor 10066810
N1019 N-Glycosylation GlyGen 29391424
K1095 Acetylation PhosphoSitePlus
K1095 Ubiquitination PhosphoSitePlus
N1124 N-Glycosylation GlyGen 29391424
K1151 Ubiquitination PhosphoSitePlus
Y1218 Phosphorylation IntAct   PhosphoSitePlus   Signor 7507203
Y1218 Phosphorylation P41240 (CSK) Signor 7507203
Y1222 Phosphorylation PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
K1254 Ubiquitination PhosphoSitePlus
K1256 Ubiquitination PhosphoSitePlus
K1270 Ubiquitination PhosphoSitePlus
S1281 Phosphorylation PhosphoSitePlus
S1285 Phosphorylation PhosphoSitePlus
T1287 Phosphorylation PhosphoSitePlus
S1293 Phosphorylation PhosphoSitePlus
S1299 Phosphorylation PhosphoSitePlus   UniProt 19690332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S176 N176 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S176 G176 Biomuta DOID:3571 / liver cancer [ cosmic ]
T193 A193 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic, icgc ]
S194 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S194 L194 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
N199 H199 Biomuta [ cosmic ]
N263 D263 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N337 S337 Biomuta [ cosmic ]
K352 E352 Biomuta DOID:3571 / liver cancer [ cosmic ]
K366 T366 Biomuta DOID:4159 / skin cancer [ cosmic ]
K366 M366 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K383 T383 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K439 E439 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S458 L458 Biomuta [ cosmic ]
S458 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N470 K470 Biomuta DOID:1324 / lung cancer [ cosmic ]
N490 K490 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K643 T643 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K643 R643 Biomuta DOID:3571 / liver cancer [ cosmic ]
K643 M643 Biomuta DOID:3571 / liver cancer [ cosmic ]
S659 R659 Biomuta DOID:1324 / lung cancer [ cosmic ]
S659 C659 Biomuta DOID:1319 / brain cancer [ cosmic ]
S665 I665 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K666 R666 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y707 C707 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K717 N717 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y765 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
Y792 C792 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T862 A862 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y902 H902 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
Y928 H928 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K934 Q934 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]
K934 N934 Biomuta DOID:4159 / skin cancer [ cosmic ]
S975 F975 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1285 G1285 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S1285 R1285 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]