Protein Information

Cytoscape View


UniProt AC / UniProt ID P08473 / NEP_HUMAN
Protein Name Neprilysin
Gene Name Name: MME
Synonyms:EPN;
Organism Homo sapiens (Human)

PRO ID PR:P08473
DAG View
PRO Name neprilysin (human)
Definition A neprilysin that is encoded in the genome of human.
Short Label hMME
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08473 (MME) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 19756956
S4 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 20166139, 22767595, 24275569
S6 Phosphorylation P68400 (CSNK2A1) , P67870 (CSNK2B) HPRD   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18578522, 8943850, 20957047, ...24275569, 20166139, 22767595
T11 Phosphorylation PhosphoSitePlus   RLIMS-P 22767595
T15 Phosphorylation PhosphoSitePlus   RLIMS-P 22767595
T25 Phosphorylation RLIMS-P 22767595
K85 Acetylation PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
N145 N-Glycosylation GlyGen   UniProt 24190977, 17704566, 10669592, ...14747736, 29741879, 12754519
T207 Phosphorylation PhosphoSitePlus
N285 N-Glycosylation GlyGen   UniProt 12754519, 24190977
N294 N-Glycosylation GlyGen 24190977
N325 N-Glycosylation GlyGen   UniProt 10669592, 14747736, 17704566
Y387 Phosphorylation PhosphoSitePlus
Y399 Phosphorylation HPRD 20068231
T407 Phosphorylation HPRD 20068231
Y482 Phosphorylation PhosphoSitePlus
Y497 Phosphorylation PhosphoSitePlus
Y502 Phosphorylation PhosphoSitePlus
Y507 Phosphorylation PhosphoSitePlus
N628 N-Glycosylation GlyGen   UniProt 10669592, 14747736, 17704566, ...22766194
S713 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T15 I15 Biomuta DOID:11934 / head and neck cancer [ tcga ]
N145 H145 Biomuta DOID:10534 / stomach cancer [ cosmic ]
N285 K285 Biomuta DOID:1324 / lung cancer [ tcga ]
N294 K294 Biomuta DOID:9256 / colorectal cancer [ tcga ]
N325 Y325 Biomuta DOID:1324 / lung cancer [ tcga ]
Y387 * Biomuta DOID:0070003 / blastoma [ cosmic ]
N628 H628 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
S713 I713 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]