Protein Information

Cytoscape View

UniProt AC / UniProt ID P08319 / ADH4_HUMAN
Protein Name All-trans-retinol dehydrogenase [NAD(+)] ADH4
Gene Name Name: ADH4
Organism Homo sapiens (Human)

PRO ID PR:P08319
DAG View
PRO Name all-trans-retinol dehydrogenase [NAD(+)] ADH4 (human)
Definition An all-trans-retinol dehydrogenase [NAD(+)] ADH4 that is encoded in the genome of human.
Short Label hADH4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P08319 (ADH4) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T83 Phosphorylation PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
S117 Phosphorylation PhosphoSitePlus
K120 Methylation PhosphoSitePlus
S121 Phosphorylation PhosphoSitePlus   UniProt 24275569
T133 Phosphorylation PhosphoSitePlus
Y144 Phosphorylation PhosphoSitePlus
K218 Acetylation PhosphoSitePlus
K254 Acetylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus   UniProt 24275569
T280 Phosphorylation PhosphoSitePlus
K342 Acetylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S278 Phosphorylation HPRD 20166139
T280 Phosphorylation HPRD 20166139

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T83 I83 Biomuta DOID:10534 / stomach cancer [ tcga ]
S121 R121 Biomuta DOID:363 / uterine cancer [ tcga ]
T133 I133 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
Y144 C144 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y144 H144 Biomuta DOID:1324 / lung cancer [ cosmic ]
K254 E254 Biomuta DOID:1909 / melanoma [ cosmic ]
T280 I280 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T355 A355 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]