iPTMnet Report for P08253 (MMP2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08253 / MMP2_HUMAN
Protein Name 72 kDa type IV collagenase precursor
Gene Name Name: MMP2
Synonyms:CLG4A;
Organism Homo sapiens (Human)

PRO ID PR:P08253
DAG View
PRO Name 72 kDa type IV collagenase (human)
Definition A 72 kDa type IV collagenase that is encoded in the genome of human.
Short Label hMMP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08253 (MMP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T11 Phosphorylation PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus 17435175
S160 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17435175
S246 Phosphorylation PhosphoSitePlus
T250 Phosphorylation PhosphoSitePlus 17435175
T250 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17435175
T261 Phosphorylation PhosphoSitePlus
Y360 Phosphorylation PhosphoSitePlus
S362 Phosphorylation PhosphoSitePlus
T364 Phosphorylation PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus 17435175
S365 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17435175
S369 Phosphorylation PhosphoSitePlus
T377 Phosphorylation PhosphoSitePlus 17435175
T377 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17435175
T378 Phosphorylation PhosphoSitePlus 17435175
T378 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 17435175
T460 O-Glycosylation GlyGen 30459171
Site PTM Type PTM Enzyme Score Source PMID
T364 Phosphorylation HPRD 20166139


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T250 S250 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S362 N362 Biomuta DOID:263 / kidney cancer [ cosmic ]
T377 A377 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
T378 K378 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]