Protein Information

Cytoscape View


UniProt AC / UniProt ID P08238 / HS90B_HUMAN
Protein Name Heat shock protein HSP 90-beta
Gene Name Name: HSP90AB1
Synonyms:HSP90B,HSPC2,HSPCB;
Organism Homo sapiens (Human)

PRO ID PR:P08238
DAG View
PRO Name heat shock protein HSP 90-beta (human)
Definition A heat shock protein HSP 90-beta that is encoded in the genome of human.
Short Label hHSP90AB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08238 (HSP90AB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y33 Phosphorylation PhosphoSitePlus
K36 Acetylation PhosphoSitePlus
K36 Ubiquitination PhosphoSitePlus
S45 Phosphorylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
Y56 Phosphorylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
T60 Phosphorylation HPRD   PhosphoSitePlus 20068231
S63 Phosphorylation PhosphoSitePlus
K64 Acetylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
S67 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
T89 Phosphorylation Q6P2M8 (PNCK) PhosphoSitePlus 21325639
T94 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
T104 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
R177 Methylation PhosphoSitePlus
K180 Sumoylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
K186 Acetylation PhosphoSitePlus
K186 Methylation PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
R196 Methylation PhosphoSitePlus
K204 Acetylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
T214 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
K219 Acetylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
S226 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25608045, 16964243, 1956339, ...25995454, 18510355, 18691976, 21406692, 23186163, 18212344, 29854279, 19691289, 18318008, 2492519, 18088087, 21210654, 18767875, 19007248, 19651622, 18591256, 17287340, 17081983, 19664994, 17322306, 18669648, 20166139, 20068231
K237 Ubiquitination PhosphoSitePlus
S255 Phosphorylation Q96GD4 (AURKB) , P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25608045, 16964243, 15302935, ...1956339, 22267324, 18510355, 15822905, 25995454, 18691976, 23186163, 18212344, 29854279, 19691289, 2492519, 18088087, 21210654, 18767875, 19007248, 19651622, 18591256, 18491316, 17287340, 17081983, 16094384, 19664994, 17322306, 18669648, 20187088, 20166139, 19415658, 20068231
S261 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18691976, 16964243, 15302935, ...19651622, 18510355, 18669648, 20166139, 19415658, 20068231, 17081983
K263 Acetylation PhosphoSitePlus
K273 Ubiquitination PhosphoSitePlus
K275 Acetylation PhosphoSitePlus
K275 Methylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
Y276 Phosphorylation PhosphoSitePlus
K284 Acetylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
T285 Phosphorylation HPRD   PhosphoSitePlus 20068231
K286 Methylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
T290 Phosphorylation PhosphoSitePlus
R291 Methylation PhosphoSitePlus
T297 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17525332, 23186163
Y301 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor   UniProt 23585225, 29127384, 17855507
Y305 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Sumoylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S307 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 20068231
T309 Phosphorylation HPRD   PhosphoSitePlus 20068231
K319 Acetylation PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
S322 Phosphorylation PhosphoSitePlus
K347 Acetylation PhosphoSitePlus
K347 Methylation PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K354 Acetylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
S365 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
S391 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
K399 Acetylation PhosphoSitePlus
K399 Sumoylation PhosphoSitePlus
K399 Ubiquitination PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
C412 S-Nitrosylation dbSNO 20140087
K423 Acetylation PhosphoSitePlus
K423 Ubiquitination PhosphoSitePlus
K427 Acetylation PhosphoSitePlus
K428 Acetylation PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
Y430 Phosphorylation PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
K435 Acetylation PhosphoSitePlus   UniProt 19608861
K435 Methylation PhosphoSitePlus
K435 Ubiquitination PhosphoSitePlus
K438 Ubiquitination PhosphoSitePlus
S445 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19651622, 23186163, 20068231
T446 Phosphorylation PhosphoSitePlus
S452 Phosphorylation Q96GD4 (AURKB) HPRD   PhosphoSitePlus 22267324, 18669648, 20068231
Y457 Phosphorylation PhosphoSitePlus
T459 Phosphorylation PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
S462 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
R475 Methylation PhosphoSitePlus
K477 Acetylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
T479 Phosphorylation PhosphoSitePlus   UniProt 23186163
K481 Acetylation PhosphoSitePlus   UniProt 19608861
K481 Ubiquitination PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
Y484 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15592455, 18083107, 20068231
Y485 Phosphorylation PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
K491 Acetylation PhosphoSitePlus
K491 Ubiquitination PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
R506 Methylation PhosphoSitePlus
Y512 Phosphorylation PhosphoSitePlus
T514 Phosphorylation HPRD 20068231
Y520 Phosphorylation PhosphoSitePlus
K526 Acetylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K531 Acetylation PhosphoSitePlus
K531 Methylation UniProt 24880080
K531 Sumoylation PhosphoSitePlus
K531 Ubiquitination PhosphoSitePlus
S532 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S535 Phosphorylation HPRD 20068231
T537 Phosphorylation PhosphoSitePlus
K538 Acetylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K550 Acetylation PhosphoSitePlus
K550 Ubiquitination PhosphoSitePlus
K551 Ubiquitination PhosphoSitePlus
K559 Acetylation PhosphoSitePlus
K559 Methylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
C564 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K565 Acetylation PhosphoSitePlus
K565 Methylation PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
K568 Acetylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K574 Acetylation PhosphoSitePlus
K574 Methylation UniProt 24880080
K574 Ubiquitination PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
T579 Phosphorylation PhosphoSitePlus
S587 Phosphorylation PhosphoSitePlus
C589 S-Nitrosylation dbSNO 26338901
C590 S-Nitrosylation dbSNO 26338901
T593 Phosphorylation PhosphoSitePlus
S594 Phosphorylation PhosphoSitePlus
T595 Phosphorylation PhosphoSitePlus
Y596 Phosphorylation HPRD   PhosphoSitePlus 19901323
T599 Phosphorylation PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
K607 Methylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
R612 Methylation PhosphoSitePlus
S615 Phosphorylation PhosphoSitePlus
T616 Phosphorylation PhosphoSitePlus
Y619 Phosphorylation PhosphoSitePlus
K623 Acetylation PhosphoSitePlus
K623 Methylation PhosphoSitePlus
K623 Ubiquitination PhosphoSitePlus
K624 Acetylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
T637 Phosphorylation PhosphoSitePlus
R639 Methylation PhosphoSitePlus
K641 Ubiquitination PhosphoSitePlus
K649 Ubiquitination PhosphoSitePlus
S669 Phosphorylation PhosphoSitePlus   UniProt 24275569
K685 Ubiquitination PhosphoSitePlus
S718 Phosphorylation Q9H4B4 (PLK3) HPRD   PhosphoSitePlus   UniProt 18669648, 22828320


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025723 (hHSF1/iso:Long/Phos:1) Interaction PR:P08238 (hHSP90AB1) PRO 16278218


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S45 C45 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y56 C56 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S58 I58 Biomuta DOID:1115 / sarcoma [ tcga ]
S63 * Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S67 I67 Biomuta DOID:363 / uterine cancer [ tcga ]
K72 N72 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T83 A83 Biomuta DOID:3953 / adrenal gland cancer [ tcga ]
T94 S94 Biomuta DOID:363 / uterine cancer [ tcga ]
K107 T107 Biomuta DOID:9256 / colorectal cancer [ tcga ]
K107 N107 Biomuta DOID:3571 / liver cancer [ icgc ]
S108 F108 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S164 A164 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K186 E186 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S206 F206 Biomuta DOID:8618 / oral cavity cancer [ icgc ]
K263 E263 Biomuta DOID:3571 / liver cancer [ tcga ]
K275 E275 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
T285 S285 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S322 A322 Biomuta DOID:263 / kidney cancer [ icgc, tcga ]
K354 T354 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S383 Y383 Biomuta DOID:2531 / hematologic cancer [ icgc ]
S383 C383 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C412 Y412 Biomuta DOID:3070 / malignant glioma [ tcga ]
K427 N427 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
K428 T428 Biomuta DOID:363 / uterine cancer [ tcga ]
Y457 C457 Biomuta DOID:1319 / brain cancer [ icgc ] DOID:3070 / malignant glioma [ cosmic ]
R475 H475 Biomuta DOID:2531 / hematologic cancer [ tcga ]
Y520 D520 Biomuta DOID:363 / uterine cancer [ tcga ]
Y520 H520 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S535 L535 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
S535 * Biomuta DOID:363 / uterine cancer [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K550 E550 Biomuta DOID:1324 / lung cancer [ tcga ]
K573 T573 Biomuta DOID:363 / uterine cancer [ tcga ]
K573 * Biomuta DOID:11934 / head and neck cancer [ tcga ]
K574 N574 Biomuta DOID:2531 / hematologic cancer [ tcga ]
R612 Q612 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T637 M637 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
K641 N641 Biomuta DOID:3571 / liver cancer [ icgc ]
S718 F718 Biomuta DOID:1909 / melanoma [ tcga ]