iPTMnet Report for P08237 (PFKM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08237 / PFKAM_HUMAN
Protein Name ATP-dependent 6-phosphofructokinase, muscle type
Gene Name Name: PFKM
Synonyms:PFKX;
Organism Homo sapiens (Human)

PRO ID PR:P08237
DAG View
PRO Name ATP-dependent 6-phosphofructokinase, muscle type (human)
Definition An ATP-dependent 6-phosphofructokinase, muscle type that is encoded in the genome of human.
Short Label hPFKM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08237 (PFKM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
Y103 Phosphorylation PhosphoSitePlus
S130 Phosphorylation PhosphoSitePlus
S133 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S198 Phosphorylation PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
R301 Methylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
R310 Methylation PhosphoSitePlus
R315 Methylation PhosphoSitePlus
T328 Phosphorylation PhosphoSitePlus
T331 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
K360 Acetylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K366 Acetylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K372 Methylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S400 Phosphorylation PhosphoSitePlus
T402 Phosphorylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K564 Acetylation PhosphoSitePlus
Y576 Phosphorylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
S667 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
R673 Methylation PhosphoSitePlus
T677 Phosphorylation PhosphoSitePlus
K678 Acetylation PhosphoSitePlus
K678 Ubiquitination PhosphoSitePlus
K682 Ubiquitination PhosphoSitePlus
K727 Acetylation PhosphoSitePlus
K727 Ubiquitination PhosphoSitePlus
K738 Acetylation PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
K754 Ubiquitination PhosphoSitePlus
Y755 Phosphorylation PhosphoSitePlus
S762 Phosphorylation PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
S775 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation HPRD 17287340
S72 Phosphorylation HPRD 20068231
T82 Phosphorylation HPRD 20068231
S377 Phosphorylation HPRD 1825608
S667 Phosphorylation HPRD 20068231
S775 Phosphorylation HPRD 1825608, 20068231
Site PTM Type PTM Enzyme Score Source PMID
K272 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K49 Ubiquitination PhosphoSitePlus
T59 Phosphorylation PhosphoSitePlus
S62 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K49 M49 Biomuta DOID:3571 / liver cancer [ cosmic ]
K49 R49 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T59 I59 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S74 L74 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4159 / skin cancer [ cosmic ]
S130 F130 Biomuta DOID:4159 / skin cancer [ cosmic ]
T202 I202 Biomuta DOID:363 / uterine cancer [ cosmic ]
K280 N280 Biomuta DOID:363 / uterine cancer [ icgc ]
R310 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S377 T377 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R673 M673 Biomuta DOID:363 / uterine cancer [ cosmic ]
R673 W673 Biomuta DOID:1324 / lung cancer [ cosmic ]
K754 N754 Biomuta DOID:1319 / brain cancer [ cosmic ]
S762 * Biomuta DOID:1612 / breast cancer [ cosmic ]