iPTMnet Report for P08235 (NR3C2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08235 / MCR_HUMAN
Protein Name Mineralocorticoid receptor
Gene Name Name: NR3C2
Synonyms:MCR,MLR;
Organism Homo sapiens (Human)

PRO ID PR:P08235
DAG View
PRO Name mineralocorticoid receptor (human)
Definition A mineralocorticoid receptor that is encoded in the genome of human.
Short Label hNR3C2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08235 (NR3C2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
Y6 Phosphorylation PhosphoSitePlus
S8 Phosphorylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
K89 Sumoylation PhosphoSitePlus
S111 Phosphorylation PhosphoSitePlus   RLIMS-P 29127314
S129 Phosphorylation neXtProt   PhosphoSitePlus 20357208
T159 Phosphorylation neXtProt 20357208
S168 Phosphorylation PhosphoSitePlus
S183 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
S227 Phosphorylation PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
S248 Phosphorylation PhosphoSitePlus
S250 Phosphorylation neXtProt   PhosphoSitePlus 20357208
S255 Phosphorylation PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S263 Phosphorylation PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
S283 O-Glycosylation GlyGen 36229526, 35254053
S283 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
S295 O-Glycosylation GlyGen 36229526, 35254053
S296 O-Glycosylation GlyGen 36229526, 35254053
S298 O-Glycosylation GlyGen 36229526, 35254053
S299 O-Glycosylation GlyGen 36229526, 35254053
S299 Phosphorylation PhosphoSitePlus
S311 Phosphorylation PhosphoSitePlus
S361 Phosphorylation PhosphoSitePlus
K399 Sumoylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
K428 Sumoylation PhosphoSitePlus
S459 Phosphorylation PhosphoSitePlus   RLIMS-P 29127314
K464 Acetylation PhosphoSitePlus
K494 Sumoylation PhosphoSitePlus
T532 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
K680 Ubiquitination PhosphoSitePlus
S703 Phosphorylation PhosphoSitePlus
T735 Phosphorylation PhosphoSitePlus   RLIMS-P 15456308
S737 Phosphorylation PhosphoSitePlus   RLIMS-P 15456308
T761 Phosphorylation PhosphoSitePlus
T800 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus   RLIMS-P 24206662
S936 Phosphorylation PhosphoSitePlus
K953 Sumoylation PhosphoSitePlus
K970 Ubiquitination PhosphoSitePlus
K977 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T159 M159 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S168 C168 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S238 F238 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S255 G255 Biomuta DOID:1324 / lung cancer [ cosmic ]
S259 F259 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S262 * Biomuta DOID:2394 / ovarian cancer [ cosmic ]
S263 R263 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S263 I263 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S274 C274 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K399 Q399 Biomuta DOID:363 / uterine cancer [ icgc ]
S424 L424 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S459 F459 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K464 R464 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S703 N703 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]