iPTMnet Report for P08183 (ABCB1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08183 / MDR1_HUMAN
Protein Name ATP-dependent translocase ABCB1
Gene Name Name: ABCB1
Synonyms:MDR1,PGY1;
Organism Homo sapiens (Human)

PRO ID PR:P08183
DAG View
PRO Name ATP-dependent translocase ABCB1 (human)
Definition An ATP-dependent translocase ABCB1 that is encoded in the genome of human.
Short Label hABCB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08183 (ABCB1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation PhosphoSitePlus
T263 Phosphorylation PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K279 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K384 Acetylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K405 Sumoylation PhosphoSitePlus
K408 Sumoylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
S419 O-Glycosylation GlyGen 33214551, 34725712, 34019948, ...29351928
T422 Phosphorylation PhosphoSitePlus
T496 Phosphorylation PhosphoSitePlus
K515 Ubiquitination PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
T522 Phosphorylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
S590 Phosphorylation PhosphoSitePlus
K617 Ubiquitination PhosphoSitePlus
K619 Ubiquitination PhosphoSitePlus
S644 Phosphorylation phospho.ELM 18669648
S658 Phosphorylation phospho.ELM 18669648
S660 Phosphorylation phospho.ELM 18669648
S661 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 7909431, 10535749, 7578013, ...18669648, 8095261, 9950764
S661 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 7909431
S667 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 7909431, 10535749, 8132598, ...7578013, 9950764
S667 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 7909431
S667 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 7909431
S671 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 7909431, 10535749, 8095261, ...9950764
S671 Phosphorylation P17252 (PRKCA) PhosphoSitePlus 7909431
S671 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 7909431
S675 Phosphorylation PhosphoSitePlus
S683 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus 7909431, 8132598
S683 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus 7909431
T684 Phosphorylation PhosphoSitePlus
S696 Phosphorylation PhosphoSitePlus
K826 Ubiquitination PhosphoSitePlus
K915 Ubiquitination PhosphoSitePlus
T1015 Phosphorylation PhosphoSitePlus
T1023 Phosphorylation PhosphoSitePlus
T1030 Phosphorylation PhosphoSitePlus
K1062 Ubiquitination PhosphoSitePlus
Y1087 Phosphorylation PhosphoSitePlus
K1093 Ubiquitination PhosphoSitePlus
K1099 Ubiquitination PhosphoSitePlus
K1102 Methylation PhosphoSitePlus
K1172 Ubiquitination PhosphoSitePlus
K1181 Ubiquitination PhosphoSitePlus
K1212 Ubiquitination PhosphoSitePlus
Y1267 Phosphorylation PhosphoSitePlus
S1269 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD 20068231
T33 Phosphorylation HPRD 18767875
S35 Phosphorylation HPRD 18767875
S644 Phosphorylation HPRD 18669648
S658 Phosphorylation HPRD 18669648
S660 Phosphorylation HPRD 18669648
S661 Phosphorylation HPRD 7909431, 18669648, 20068231
S667 Phosphorylation HPRD 7909431
S671 Phosphorylation HPRD 7909431
S683 Phosphorylation HPRD 7909431


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q03135 (CAV1) Y14 P08183 (ABCB1) decreased_association eFIP 31113938


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T263 S263 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K271 N271 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K279 T279 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K367 N367 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K372 R372 Biomuta DOID:3571 / liver cancer [ cosmic ]
K380 N380 Biomuta DOID:263 / kidney cancer [ cosmic ]
K408 T408 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
T422 R422 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K619 E619 Biomuta DOID:1324 / lung cancer [ cosmic ]
S644 F644 Biomuta [ cosmic ]
S658 P658 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S660 C660 Biomuta DOID:1319 / brain cancer [ cosmic ]
S667 L667 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ]
S667 T667 Biomuta DOID:1324 / lung cancer [ cosmic ]
S675 L675 Biomuta DOID:4159 / skin cancer [ cosmic ]
S696 F696 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K915 R915 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
K915 T915 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T1015 S1015 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1062 N1062 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1267 C1267 Biomuta DOID:1324 / lung cancer [ cosmic ]