Protein Information

Cytoscape View


UniProt AC / UniProt ID P08133 / ANXA6_HUMAN
Protein Name Annexin A6
Gene Name Name: ANXA6
Synonyms:ANX6;
Organism Homo sapiens (Human)

PRO ID PR:P08133
DAG View
PRO Name annexin A6 (human)
Definition An annexin A6 that is encoded in the genome of human.
Short Label hANXA6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08133 (ANXA6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 25944712
K3 Acetylation PhosphoSitePlus
K9 Acetylation PhosphoSitePlus
K9 Ubiquitination PhosphoSitePlus
Y10 Phosphorylation PhosphoSitePlus
R11 Methylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y30 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 19690332, 24275569
K34 Ubiquitination PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
S49 Phosphorylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus   UniProt 19608861
K63 Ubiquitination PhosphoSitePlus
K68 Acetylation PhosphoSitePlus   UniProt 19608861
K68 Ubiquitination PhosphoSitePlus
K75 Acetylation PhosphoSitePlus   UniProt 19608861
K75 Ubiquitination PhosphoSitePlus
Y76 Phosphorylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus   UniProt 19608861
K81 Ubiquitination PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
K99 Acetylation PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
K102 Acetylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
C114 S-Nitrosylation dbSNO 19483679
S121 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
T221 O-Glycosylation GlyGen 29351928
T222 O-Glycosylation GlyGen 29351928
K224 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
T252 Phosphorylation RLIMS-P 7777579
R259 Methylation PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
T269 Phosphorylation PhosphoSitePlus
T273 Phosphorylation PhosphoSitePlus
S282 Phosphorylation PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus
K299 Acetylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
Y302 Phosphorylation PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K306 Acetylation PhosphoSitePlus   UniProt 19608861
K306 Ubiquitination PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus
K314 Acetylation PhosphoSitePlus
Y340 Phosphorylation PhosphoSitePlus
T356 Phosphorylation PhosphoSitePlus
K370 Acetylation PhosphoSitePlus   UniProt 19608861
K370 Ubiquitination PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
T381 Phosphorylation PhosphoSitePlus
T391 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K418 Acetylation PhosphoSitePlus   UniProt 19608861
K418 Ubiquitination PhosphoSitePlus
S419 Phosphorylation PhosphoSitePlus
S422 Phosphorylation PhosphoSitePlus
K442 Acetylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
K478 Acetylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
K483 Acetylation PhosphoSitePlus   UniProt 19608861
K483 Ubiquitination PhosphoSitePlus
S490 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
T535 Phosphorylation PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus   UniProt 24275569
K540 Ubiquitination PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
Y572 Phosphorylation PhosphoSitePlus
K579 Ubiquitination PhosphoSitePlus
K580 Acetylation PhosphoSitePlus
S583 Phosphorylation PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
K607 Ubiquitination PhosphoSitePlus
Y609 Phosphorylation PhosphoSitePlus
K613 Acetylation PhosphoSitePlus
K620 Acetylation PhosphoSitePlus   UniProt 19608861
K620 Ubiquitination PhosphoSitePlus
S630 Phosphorylation PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
K647 Acetylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
S658 Phosphorylation PhosphoSitePlus
K663 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y30 Phosphorylation HPRD 18083107
T48 Phosphorylation HPRD 20068231
S229 Phosphorylation HPRD 20068231
S251 Phosphorylation HPRD 20068231
T381 Phosphorylation HPRD 18767875
T391 Phosphorylation HPRD 18767875, 18452278


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
A2 S2 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
R11 W11 Biomuta DOID:1324 / lung cancer [ cosmic ]
R11 Q11 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
K81 T81 Biomuta DOID:5041 / esophageal cancer [ icgc ]
Y185 * Biomuta DOID:3571 / liver cancer [ icgc ]
Y302 C302 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
K314 N314 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
T391 A391 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S419 F419 Biomuta DOID:1909 / melanoma [ tcga ]
T464 I464 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S490 R490 Biomuta DOID:3571 / liver cancer [ icgc ]
S503 Y503 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K607 T607 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]