iPTMnet Report for P08100 (RHO)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P08100 / OPSD_HUMAN
Protein Name Rhodopsin
Gene Name Name: RHO
Synonyms:OPN2;
Organism Homo sapiens (Human)

PRO ID PR:P08100
DAG View
PRO Name rhodopsin (human)
Definition A rhodopsin that is encoded in the genome of human.
Short Label hRHO
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08100 (RHO) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N15 N-Glycosylation GlyGen   UniProt 28753425
Y136 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation PhosphoSitePlus
S334 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 28753425, 9099669, 8617805, ...11910029, 11498053, 9303550
S334 Phosphorylation P17252 (PRKCA) HPRD 8617805, 11498053, 11910029, ...9099669
S334 Phosphorylation Q15835 (GRK1) HPRD 8617805, 11498053, 11910029, ...9099669
T336 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 30679635, 28753425, 9099669, ...7662865, 31251171
T336 Phosphorylation P17252 (PRKCA) HPRD 9099669
S338 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 11498053, 28753425, 31251171, ...8617805, 11910029, 7662865
S338 Phosphorylation Q15835 (GRK1) HPRD 8617805, 11498053, 11910029
T340 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 11910029, 9169442
T342 Phosphorylation RLIMS-P 20532191
S343 Phosphorylation HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P 8617805, 11910029, 11498053, ...7662865
S343 Phosphorylation Q15835 (GRK1) HPRD 8617805, 11498053, 11910029


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049043 (hRHO/Phos:1) pS334,pS338,pS343 PRO


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:O95405-1 (hZFYVE9/iso:1) Interaction PR:P08100 (hRHO) PRO 17693260


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T340 R340 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T340 M340 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:5041 / esophageal cancer [ cosmic ]
T342 M342 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ]
S343 C343 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]