Protein Information

Cytoscape View


UniProt AC / UniProt ID P08047 / SP1_HUMAN
Protein Name Transcription factor Sp1
Gene Name Name: SP1
Synonyms:TSFP1;
Organism Homo sapiens (Human)

PRO ID PR:P08047
DAG View
PRO Name transcription factor Sp1 (human)
Definition A transcription factor Sp1 that is encoded in the genome of human.
Short Label hSP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P08047 (SP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 21406692, 20068231
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S7 Phosphorylation PhosphoSitePlus   UniProt 18239466, 21406692, 23186163, ...20068231
T12 Phosphorylation PhosphoSitePlus
K16 Sumoylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S40 Phosphorylation phospho.ELM 18669648
S41 Phosphorylation phospho.ELM 18669648
S42 Phosphorylation P31749 (AKT1) phospho.ELM   PhosphoSitePlus 18669648, 22718198
T43 Phosphorylation phospho.ELM 18669648
S45 Phosphorylation PhosphoSitePlus
S46 Phosphorylation phospho.ELM 18669648
S48 Phosphorylation phospho.ELM 18669648
T49 Phosphorylation PhosphoSitePlus
S56 Phosphorylation Q13315 (ATM) phospho.ELM   PhosphoSitePlus 18669648, 18619531
S59 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18199680, 18239466, 23186163, ...16964243, 15302935, 17049555, 11904305, 19318349
S73 Phosphorylation PhosphoSitePlus
S101 Phosphorylation Q13315 (ATM) , Q13535 (ATR) neXtProt   PhosphoSitePlus   Signor   UniProt 18171990, 17609267, 18619531
S120 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S126 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T128 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S134 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T254 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T265 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S271 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S273 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T276 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T278 Phosphorylation P45983 (MAPK8) neXtProt   PhosphoSitePlus   Signor   UniProt 18199680, 19245816
S312 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T394 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S421 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T424 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S446 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T453 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T453 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 32615164, 14744793, 16377629, ...14593115, 11904305, 19318349, 20882567
T455 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S491 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 9343410, 11371615
S507 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
S510 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T517 O-Glycosylation GlyGen 23301498, 24129563, 21795679, ...21740066, 9111324, 20699577, 31847126, 24802710, 16408927, 21105874, 24995865, 25352121, 31866443, 30397120, 24553187, 28054006, 19302979, 20305658, 17614351, 27655845, 9452489, 20657584, 9079710, 29351928, 23013401, 16027160, 28510447, 26499076
T579 Phosphorylation P68400 (CSNK2A1) phospho.ELM   Signor 9153193
K610 Ubiquitination PhosphoSitePlus
S612 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 16332679
S612 Phosphorylation UniProt 16332679
R615 Methylation PhosphoSitePlus
S617 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
T640 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 16332679
T640 Phosphorylation UniProt 16332679
S641 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 16332679
S641 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   Signor   UniProt 16332679, 16943418, 19464346, ...18258854
T651 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T668 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   Signor   UniProt 16943418, 18258854
S670 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   Signor   UniProt 16943418, 18258854
T679 Phosphorylation P31749 (AKT1) PhosphoSitePlus 22718198
T681 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   Signor   UniProt 17049555, 16943418, 18258854
K684 Acetylation PhosphoSitePlus
K685 Ubiquitination PhosphoSitePlus
K693 Ubiquitination PhosphoSitePlus
S698 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 16332679
S698 Phosphorylation P31749 (AKT1) PhosphoSitePlus   UniProt 16332679, 22718198
S702 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 16332679
S702 Phosphorylation PhosphoSitePlus   UniProt 20953893, 16332679
K703 Acetylation PhosphoSitePlus   UniProt 16478997
T707 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
T723 Phosphorylation PhosphoSitePlus
S728 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P+ 19372209
S732 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   RLIMS-P+ 19372209
T737 Phosphorylation PhosphoSitePlus
T739 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) , P06493 (CDK1) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor   UniProt 18199680, 19245816, 20882567, ...14744793, 20150555, 22266860, 16377629, 14593115, 11904305, 19318349
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 19651622, 20068231
S7 Phosphorylation HPRD 19651622, 20068231
K16 Sumoylation PRO 16407261
S40 Phosphorylation HPRD 18669648
S41 Phosphorylation HPRD 18669648
S42 Phosphorylation HPRD 18669648
T43 Phosphorylation HPRD 18669648
S46 Phosphorylation HPRD 18669648
S48 Phosphorylation HPRD 18669648
S56 Phosphorylation HPRD 18669648
S59 Phosphorylation HPRD   PRO 17049555, 18239466, 15302935, ...16964243
T375 Phosphorylation HPRD 20068231
T453 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 11904305
S491 O-Glycosylation PRO 9343410, 11371615
T579 Phosphorylation P68400 (CSNK2A1) HPRD   PRO 9153193
S617 Phosphorylation HPRD 20068231
T651 Phosphorylation HPRD 18669648
K703 Acetylation PR:Q09472 (hEP300) PRO 16478997
T739 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) HPRD 11904305


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028672 (hSP1/iso:1/Ac:2) acK703 PR:Q09472 (hEP300) PRO 16478997
PR:000036500 (hSP1/iso:1/Phos:2) pT579 PRO 9153193
PR:000036501 (hSP1/iso:1/Phos:3) pS59 PRO 17049555, 18239466
PR:000036503 (hSP1/iso:1/Sumo:1) suK16 PRO 16407261