iPTMnet Report for P07992 (ERCC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07992 / ERCC1_HUMAN
Protein Name DNA excision repair protein ERCC-1
Gene Name Name: ERCC1
Organism Homo sapiens (Human)

PRO ID PR:P07992
DAG View
PRO Name DNA excision repair protein ERCC-1 (human)
Definition A DNA excision repair protein ERCC-1 that is encoded in the genome of human.
Short Label hERCC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07992 (ERCC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
M1 Acetylation UniProt 22814378
S14 Phosphorylation PhosphoSitePlus
K21 Ubiquitination PhosphoSitePlus
K37 Acetylation PhosphoSitePlus
K37 Ubiquitination PhosphoSitePlus
S104 Phosphorylation PhosphoSitePlus
K114 Ubiquitination PhosphoSitePlus
K162 Ubiquitination PhosphoSitePlus
C194 Methylation IEDB 31844290
K213 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
C238 Methylation IEDB 31844290
K243 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K295 Acetylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
K281 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047324 (hERCC1/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S14 L14 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S14 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K21 T21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]