Protein Information

Cytoscape View


UniProt AC / UniProt ID P07954 / FUMH_HUMAN
Protein Name Fumarate hydratase, mitochondrial precursor
Gene Name Name: FH
Organism Homo sapiens (Human)

PRO ID PR:P07954
DAG View
PRO Name fumarate hydratase, mitochondrial (human)
Definition A fumarate hydratase, mitochondrial that is encoded in the genome of human.
Short Label hFH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07954 (FH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
K61 Acetylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K66 Acetylation PhosphoSitePlus   UniProt 19608861
K66 Ubiquitination PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus   RLIMS-P 28628081
K80 Acetylation PhosphoSitePlus   UniProt 19608861
T85 Phosphorylation PhosphoSitePlus
T90 Phosphorylation PhosphoSitePlus   UniProt 23186163
K94 Acetylation PhosphoSitePlus   UniProt 19608861
K94 Ubiquitination PhosphoSitePlus
K100 Methylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
Y110 Phosphorylation PhosphoSitePlus
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
K172 Acetylation PhosphoSitePlus
K172 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
T236 Phosphorylation P78527 (PRKDC) PhosphoSitePlus   RLIMS-P   UniProt 26237645
Y251 Phosphorylation PhosphoSitePlus
K256 Acetylation PhosphoSitePlus   UniProt 19608861
K292 Acetylation PhosphoSitePlus   UniProt 19608861
K292 Ubiquitination PhosphoSitePlus
T301 Phosphorylation PhosphoSitePlus
R343 Methylation PhosphoSitePlus
S351 Phosphorylation PhosphoSitePlus
S366 Phosphorylation PhosphoSitePlus   UniProt 24275569
Y465 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
K470 Acetylation PhosphoSitePlus
K473 Acetylation PhosphoSitePlus
K477 Acetylation PhosphoSitePlus
Y491 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T493 Phosphorylation PhosphoSitePlus
K502 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y270 Phosphorylation HPRD 20068231
T301 Phosphorylation HPRD 19413330
Y491 Phosphorylation HPRD 18083107


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S46 R46 Biomuta DOID:11934 / head and neck cancer [ tcga ]
Y54 * Biomuta DOID:10534 / stomach cancer [ cosmic ]
Y67 H67 Biomuta DOID:3571 / liver cancer [ tcga ]
Y67 S67 Biomuta DOID:1324 / lung cancer [ tcga ]
Y68 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T85 A85 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
T85 K85 Biomuta DOID:3571 / liver cancer [ icgc ]
T90 I90 Biomuta DOID:1324 / lung cancer [ tcga ]
K100 N100 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K115 N115 Biomuta DOID:1612 / breast cancer [ tcga ]
S171 C171 Biomuta DOID:1324 / lung cancer [ cosmic ]
R343 Q343 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ]
R343 * Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S351 T351 Biomuta DOID:1909 / melanoma [ cosmic ]
S351 * Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
K470 R470 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]