Protein Information

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UniProt AC / UniProt ID P07948 / LYN_HUMAN
Protein Name Tyrosine-protein kinase Lyn
Gene Name Name: LYN
Synonyms:JTK8;
Organism Homo sapiens (Human)

PRO ID PR:P07948
DAG View
PRO Name tyrosine-protein kinase Lyn (human)
Definition A tyrosine-protein kinase Lyn that is encoded in the genome of human.
Short Label hLYN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07948 (LYN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 18817770, 25255805
K9 Ubiquitination PhosphoSitePlus
S11 Phosphorylation PhosphoSitePlus   UniProt 18691976, 21406692, 23186163, ...19369195, 24275569
S13 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18691976, 21406692, 23186163, ...19369195, 17192257, 24275569, 18088087, 33004926, 20068231
K20 Ubiquitination PhosphoSitePlus
T30 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus 23764002
Y32 Phosphorylation P00533 (EGFR) PhosphoSitePlus 23764002
K40 Ubiquitination PhosphoSitePlus
T58 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K101 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S115 Phosphorylation PhosphoSitePlus
Y117 Phosphorylation PhosphoSitePlus
K132 Ubiquitination PhosphoSitePlus
T135 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus
K181 Ubiquitination PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
Y193 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 18577747, 16497976
Y194 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S196 Phosphorylation PhosphoSitePlus
K213 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
S228 Phosphorylation PhosphoSitePlus   UniProt 19369195
S246 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
Y266 Phosphorylation PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
T276 Phosphorylation PhosphoSitePlus
T281 Phosphorylation PhosphoSitePlus
S283 Phosphorylation PhosphoSitePlus
T296 Phosphorylation PhosphoSitePlus
Y306 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18083107
Y316 Phosphorylation PhosphoSitePlus   UniProt 19369195
T319 Phosphorylation PhosphoSitePlus
Y321 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
Y397 Phosphorylation neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 32547702, 23422267, 20564182, ...17081983, 30590041, 14563648, 27297662, 21636860, 7935444, 24404189, 18083107, 18070987, 25751262, 8530369, 18088087, 30979953, 17517964
Y397 Phosphorylation P07948 (LYN) neXtProt   phospho.ELM   UniProt 14563648, 18070987, 21636860, ...8530369
T398 Phosphorylation PhosphoSitePlus
K404 Ubiquitination PhosphoSitePlus
T438 Phosphorylation PhosphoSitePlus
Y439 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus
Y460 Phosphorylation PhosphoSitePlus   UniProt 18577747
Y473 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18083107, 18691976, 19369195
K477 Ubiquitination PhosphoSitePlus
Y501 Phosphorylation PhosphoSitePlus
T502 Phosphorylation PhosphoSitePlus
T504 Phosphorylation PhosphoSitePlus
Y508 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18691976, 18070987, 15626731, ...23936469, 9171348, 30590041, 19369195, 7935444, 18083107, 14985335, 9058799, 15592455, 17905674, 1722201
Y508 Phosphorylation P07948 (LYN) UniProt 18070987
Y508 Phosphorylation P41240 (CSK) neXtProt   phospho.ELM   Signor 7935444, 1722201, 9171348, ...15626731
Y508 Phosphorylation P42679 (MATK) neXtProt   PhosphoSitePlus 14985335, 9171348
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD 18691976, 17081983, 18767875, ...19651622, 18669648, 20068231
S13 Phosphorylation HPRD 18691976, 18088087, 18767875, ...19664994, 19007248, 19691289, 19651622, 17322306, 18669648, 20166139, 19415658, 20068231
Y32 Phosphorylation HPRD 18691976
Y193 Phosphorylation HPRD 18083107, 16497976
Y194 Phosphorylation HPRD 17016520, 18083107, 16497976, ...18691976
S228 Phosphorylation HPRD 18691976
S246 Phosphorylation HPRD 20068231
Y306 Phosphorylation HPRD 20068231
Y316 Phosphorylation HPRD 17389395
Y397 Phosphorylation HPRD 19901323, 18691976, 18088087, ...20068231, 9171348
Y397 Phosphorylation P07948 (LYN) HPRD 19901323, 18691976, 18088087, ...20068231, 9171348
Y473 Phosphorylation HPRD 18083107, 18691976
T489 Phosphorylation HPRD 18691976
Y492 Phosphorylation HPRD 16497976
Y501 Phosphorylation HPRD 17081983, 16497976
T504 Phosphorylation HPRD 18691976
Y508 Phosphorylation HPRD 19901323, 18691976, 8612628, ...18452278, 19651622, 18669648, 20068231, 16497976
Y508 Phosphorylation P41240 (CSK) HPRD 19901323, 18691976, 8612628, ...18452278, 19651622, 18669648, 20068231, 16497976
Y508 Phosphorylation P42679 (MATK) HPRD 19901323, 18691976, 8612628, ...18452278, 19651622, 18669648, 20068231, 16497976
Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation PhosphoSitePlus
S13 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
Y376 Phosphorylation PhosphoSitePlus
Y487 Phosphorylation PhosphoSitePlus


P07948 (LYN) as PTM Enzyme



Substrate Site Score Source PMID
O14920 (IKBKB) Y188 PhosphoSitePlus 26353931
O14920 (IKBKB) Y199 PhosphoSitePlus 26353931
O15492 (RGS16) Y168 HPRD   PhosphoSitePlus 12588871, 11602604
O15492 (RGS16) Y177 phospho.ELM   PhosphoSitePlus 12588871
O43823 (AKAP8) Y51 PhosphoSitePlus 25770215
O43823 (AKAP8) Y53 PhosphoSitePlus 25770215
O43823 (AKAP8) Y80 PhosphoSitePlus 25770215
O43823 (AKAP8) Y146 PhosphoSitePlus 25770215
O43823 (AKAP8) Y150 PhosphoSitePlus 25770215
O43823 (AKAP8) Y152 PhosphoSitePlus 25770215
O43823 (AKAP8) Y154 PhosphoSitePlus 25770215
O43823 (AKAP8) Y170 PhosphoSitePlus 25770215
O43823 (AKAP8) Y311 PhosphoSitePlus 25770215
O43823 (AKAP8) Y436 PhosphoSitePlus 25770215
O43823 (AKAP8) Y539 PhosphoSitePlus 25770215
O60496 (DOK2) Y271 HPRD 10428862
O60496 (DOK2) Y299 HPRD 19901323, 10428862, 16497976
O60496 (DOK2) Y345 HPRD 10428862
O60711 (LPXN) Y72 neXtProt   Signor 17640867
P00519 (ABL1) Y70 PhosphoSitePlus 16912036
P00519 (ABL1) Y115 PhosphoSitePlus 16912036
P00519 (ABL1) Y128 PhosphoSitePlus 16912036
P00519 (ABL1) Y139 PhosphoSitePlus 16912036
P00519 (ABL1) Y172 PhosphoSitePlus 16912036
P00519 (ABL1) Y185 PhosphoSitePlus 16912036
P00519 (ABL1) Y215 PhosphoSitePlus 16912036
P00519 (ABL1) Y226 PhosphoSitePlus 16912036
P00519 (ABL1) Y393 PhosphoSitePlus 16912036
P02730 (SLC4A1) Y8 HPRD   phospho.ELM   PhosphoSitePlus 10942405, 2065070, 1998697, ...17404032
P02730 (SLC4A1) Y21 HPRD   phospho.ELM   PhosphoSitePlus 10942405, 2065070, 1998697, ...17404032
P02730-1 (SLC4A1) Y359 HPRD   phospho.ELM   PhosphoSitePlus 10942405, 2065070, 17404032
P02730 (SLC4A1) Y904 HPRD   phospho.ELM   PhosphoSitePlus 10942405, 2065070, 17404032
P06493 (CDK1) Y15 HPRD   RLIMS-P+ 17016520, 19413330, 18691976, ...8084605, 20058876, 18452278, 19651622, 18669648, 19901323, 10564259, 7530044, 19415658, 20068231, 16497976
P07948 (LYN) Y397 HPRD   neXtProt   phospho.ELM   UniProt 19901323, 18691976, 18070987, ...18088087, 14563648, 21636860, 9171348, 8530369, 20068231
P07948 (LYN) Y508 UniProt 18070987
P11137 (MAP2) Y67 phospho.ELM 15536091
P11274 (BCR) Y177 PhosphoSitePlus 16912036
P11802 (CDK4) Y17 neXtProt   PhosphoSitePlus 18479465
P11912-2 (CD79A) Y150 HPRD 9531288
P11912-1 (CD79A) Y188 HPRD   phospho.ELM 9531288
P12318-2 (FCGR2A) Y280 HPRD 8756631
P12318 (FCGR2A) Y281 phospho.ELM 8756631
P12318-2 (FCGR2A) Y287 HPRD 8756631
P12318 (FCGR2A) Y288 phospho.ELM 8756631
P12318-2 (FCGR2A) Y303 HPRD 8756631
P12318 (FCGR2A) Y304 phospho.ELM   PhosphoSitePlus 8756631
P13569 (CFTR) Y512 RLIMS-P+ 24178769
P13569 (CFTR) Y515 RLIMS-P+ 24178769
P13569 (CFTR) Y517 RLIMS-P+ 24178769
P14317 (HCLS1) Y222 HPRD   phospho.ELM   PhosphoSitePlus 15795233, 10066823
P14317 (HCLS1) Y378 HPRD   phospho.ELM   Signor 9104825
P14317-1 (HCLS1) Y397 HPRD   phospho.ELM   Signor 9104825
P15391-1 (CD19) Y409 HPRD   neXtProt 10933394
P15391 (CD19) Y500 HPRD   phospho.ELM   PhosphoSitePlus   Signor 10933394
P15391-1 (CD19) Y531 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 10933394, 16497976
P15941 (MUC1) Y1229 neXtProt 12750561
P16885 (PLCG2) Y743 phospho.ELM 12181444
P16885 (PLCG2) Y753 HPRD 7682059, 12181444, 15144186
P16885 (PLCG2) Y759 HPRD 19901323, 7682059, 12181444, ...16497976
P19174-1 (PLCG1) Y771 HPRD   RLIMS-P+ 17016520, 17389395, 7682059, ...15144186, 8657103, 1689310, 20068231, 16497976
P19174-1 (PLCG1) Y783 HPRD 17016520, 17389395, 7682059, ...8657103, 20068231, 1689310, 8885868, 16497976
P19235 (EPOR) Y368 phospho.ELM 10579919
P21854 (CD72) Y7 neXtProt 9590210
P21854 (CD72) Y39 neXtProt 9590210
P22681 (CBL) Y371 PhosphoSitePlus 24469048
P24941 (CDK2) Y15 RLIMS-P+ 8806683
P25490 (YY1) Y8 PhosphoSitePlus 26198631
P25490 (YY1) Y254 PhosphoSitePlus 26198631
P25490 (YY1) Y383 PhosphoSitePlus 26198631
P29350 (PTPN6) Y536 PhosphoSitePlus 17675340
P29350 (PTPN6) Y564 HPRD   Signor 8692915, 10574931, 8114715, ...10488096, 12468540
P30419 (NMT1) Y117 phospho.ELM 11594778
P30419 (NMT1) Y180 HPRD   phospho.ELM   PhosphoSitePlus 11594778
P31994-5 (FCGR2B) Y272 HPRD 8756631
P31994-2 (FCGR2B) Y273 HPRD 8756631
P31994-4 (FCGR2B) Y291 HPRD 8756631
P31994 (FCGR2B) Y292 HPRD   phospho.ELM   PhosphoSitePlus 8756631
P31995 (FCGR2C) Y310 phospho.ELM   PhosphoSitePlus 8756631
P32927 (CSF2RB) Y466 PhosphoSitePlus 10672044
P32927 (CSF2RB) Y468 PhosphoSitePlus 10672044
P32927 (CSF2RB) Y822 PhosphoSitePlus 10672044
P32927 (CSF2RB) Y882 PhosphoSitePlus 10672044
P33993 (MCM7) Y600 PhosphoSitePlus 23764002
P35354 (PTGS2) Y120 PhosphoSitePlus 24970799
P37840-1 (SNCA) Y125 HPRD 12096713, 11162638, 11744621
P40259-2 (CD79B) Y92 HPRD 9531288
P40259-2 (CD79B) Y103 HPRD 9531288
P40259 (CD79B) Y196 HPRD   phospho.ELM 9531288
P40259 (CD79B) Y207 HPRD   phospho.ELM 9531288
P42229 (STAT5A) Y694 neXtProt   phospho.ELM 9573010, 11641791
P42680 (TEC) Y519 neXtProt 9473212
P42768 (WAS) Y291 PhosphoSitePlus 12769846
P43405-1 (SYK) Y131 HPRD 9820500
P43405 (SYK) Y323 neXtProt 9820500, 14871838
P43405 (SYK) Y348 neXtProt 9820500, 14871838
P43405 (SYK) Y352 neXtProt 9820500, 14871838
P46527 (CDKN1B) Y88 HPRD   neXtProt   PhosphoSitePlus   Signor 21423214, 17254966
P60484 (PTEN) Y240 PhosphoSitePlus 22891331
P68400 (CSNK2A1) Y255 phospho.ELM 12628006
Q05655-1 (PRKCD) Y52 HPRD 7575560, 10945993
Q05655-1 (PRKCD) Y64 HPRD 7575560, 10945993
Q05655-1 (PRKCD) Y155 HPRD 7575560, 10945993
Q05655-1 (PRKCD) Y187 HPRD 7575560, 10945993
Q05655 (PRKCD) Y313 neXtProt 20190138, 18387943
Q05655 (PRKCD) Y334 neXtProt 20190138, 18387943
Q05655-1 (PRKCD) Y567 HPRD 7575560, 10945993
Q06187 (BTK) Y223 PhosphoSitePlus 9326643
Q06187 (BTK) Y551 HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11598012, 8630736, 11226282, ...8629002, 9326643
Q12972-3 (PPP1R8) Y40 HPRD 11104670
Q12972-3 (PPP1R8) Y111 HPRD 11104670
Q12972-2 (PPP1R8) Y122 HPRD 11104670
Q12972-2 (PPP1R8) Y193 HPRD 11104670
Q12972 (PPP1R8) Y264 HPRD   phospho.ELM 11104670
Q12972 (PPP1R8) Y335 HPRD   phospho.ELM   PhosphoSitePlus 11104670
Q13263 (TRIM28) Y449 PhosphoSitePlus 23645696
Q13263 (TRIM28) Y458 PhosphoSitePlus 23645696
Q13263 (TRIM28) Y517 PhosphoSitePlus 23645696
Q13291 (SLAMF1) Y327 phospho.ELM   PhosphoSitePlus   Signor 15315965
Q14790 (CASP8) Y380 PhosphoSitePlus 18086677
Q14790 (CASP8) Y448 PhosphoSitePlus 18086677
Q8N6F7 (GCSAM) Y107 PhosphoSitePlus 17489982
Q8N6F7 (GCSAM) Y128 PhosphoSitePlus 17489982
Q92918-1 (MAP4K1) Y381 HPRD 11514608
Q9GZY6 (LAT2) Y95 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y110 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y118 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y119 PhosphoSitePlus 17993265
Q9GZY6 (LAT2) Y136 PhosphoSitePlus 17993265
Q9H792 (PEAK1) Y635 PhosphoSitePlus 23378338
Q9HBA0-1 (TRPV4) Y253 HPRD   phospho.ELM 12538589
Q9NWQ8 (PAG1) Y105 neXtProt 16920712
Q9UN19-1 (DAPP1) Y139 HPRD   PhosphoSitePlus 19901323, 10880360, 17389395
Q9Y6Y9 (LY96) Y22 PhosphoSitePlus 21918188
Q9Y6Y9 (LY96) Y131 PhosphoSitePlus 21918188


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048279 (hLYN/InitMet-/Phos:2) pY397 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04049 (RAF1) S259 P07948 (LYN) increased_association eFIP 22182854
Phosphorylation P14317 (HCLS1) Y397 P07948 (LYN) unknown eFIP 15795233
Phosphorylation P31994 (FCGR2B) Y292 P07948 (LYN) unknown eFIP 10382761
Phosphorylation Q06649 (Sh3bp2) Y446 P07948 (LYN) unknown eFIP 12709437
Phosphorylation Q08345 (DDR1) Y586 P07948 (LYN) unknown eFIP 22057045
Phosphorylation Q8IZP0 (ABI1) Y421 P07948 (LYN) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K40 I40 Biomuta DOID:1324 / lung cancer [ cosmic ]
K109 T109 Biomuta DOID:263 / kidney cancer [ tcga ]
S115 R115 Biomuta DOID:1324 / lung cancer [ cosmic ]
S149 I149 Biomuta DOID:363 / uterine cancer [ tcga ]
S149 R149 Biomuta DOID:1324 / lung cancer [ cosmic ]
S164 T164 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y194 H194 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K224 N224 Biomuta DOID:1612 / breast cancer [ tcga ]
T398 K398 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
K404 N404 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]