Protein Information

Cytoscape View

UniProt AC / UniProt ID P07947 / YES_HUMAN
Protein Name Tyrosine-protein kinase Yes
Gene Name Name: YES1
Organism Homo sapiens (Human)

PRO ID PR:P07947
DAG View
PRO Name tyrosine-protein kinase Yes (human)
Definition A tyrosine-protein kinase Yes that is encoded in the genome of human.
Short Label hYES1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P07947 (YES1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S11 Phosphorylation HPRD   PhosphoSitePlus 18691976
K15 Ubiquitination PhosphoSitePlus
Y16 Phosphorylation PhosphoSitePlus
T21 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 18669648
S26 Phosphorylation HPRD   PhosphoSitePlus 18691976
T27 Phosphorylation HPRD 18691976
S28 Phosphorylation HPRD   PhosphoSitePlus 18691976
S30 Phosphorylation HPRD   PhosphoSitePlus 18691976
Y32 Phosphorylation P07947 (YES1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 18083107, 9058199
T37 Phosphorylation PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S40 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 18669648
S44 Phosphorylation HPRD   phospho.ELM 18669648
S45 Phosphorylation HPRD   PhosphoSitePlus 18669648
S46 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
S111 Phosphorylation HPRD   PhosphoSitePlus 18691976
K138 Ubiquitination PhosphoSitePlus
Y141 Phosphorylation PhosphoSitePlus
S144 Phosphorylation PhosphoSitePlus
Y146 Phosphorylation PhosphoSitePlus
Y159 Phosphorylation PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
T190 Phosphorylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
Y194 Phosphorylation HPRD   PhosphoSitePlus 18669648
S195 Phosphorylation HPRD   PhosphoSitePlus 18691976
S197 Phosphorylation PhosphoSitePlus
Y222 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
Y223 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T226 Phosphorylation PhosphoSitePlus
K235 Ubiquitination PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
S276 Phosphorylation PhosphoSitePlus
K325 Ubiquitination PhosphoSitePlus
Y336 Phosphorylation PhosphoSitePlus   UniProt 19369195
Y345 Phosphorylation PhosphoSitePlus   UniProt 19369195
S355 Phosphorylation PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
Y426 Phosphorylation P07947 (YES1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19651622, 9058199, 17081983, ...16094384, 9794236, 17192257, 18083107, 18691976, 18669648, 18707149
T427 Phosphorylation PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
Y446 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107
K468 Ubiquitination PhosphoSitePlus
Y489 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
T531 Phosphorylation PhosphoSitePlus
T533 Phosphorylation PhosphoSitePlus
Y537 Phosphorylation P41240 (CSK) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19369195, 18691976, 7690925, ...16439366, 18083107

P07947 (YES1) as PTM Enzyme

Substrate Site Score Source PMID
P07947 (YES1) Y32 neXtProt 9058199
P07947 (YES1) Y426 HPRD   neXtProt   Signor   UniProt 18691976, 9058199, 17081983, ...9794236, 19651622, 18669648, 18707149
P11802 (CDK4) Y17 neXtProt   PhosphoSitePlus   Signor 18479465
P15529-7 (CD46) Y324 HPRD 11901164
P15529-4 (CD46) Y338 HPRD 11901164
P15529-3 (CD46) Y353 HPRD 11901164
P15529-4 (CD46) Y354 neXtProt 11901164
P15529-2 (CD46) Y368 HPRD 11901164
P46527 (CDKN1B) Y74 HPRD   neXtProt   PhosphoSitePlus 17254967
P46527 (CDKN1B) Y88 HPRD   neXtProt   PhosphoSitePlus 17254967
P46527 (CDKN1B) Y89 neXtProt   PhosphoSitePlus 17254967
Q05397 (PTK2) Y576 neXtProt 16293639
Q05397 (PTK2) Y861 PhosphoSitePlus 25868388
Q05397 (PTK2) Y925 PhosphoSitePlus 25868388
Q05655 (PRKCD) Y313 neXtProt 18387943
Q05655 (PRKCD) Y334 neXtProt 18387943
Q16543 (CDC37) Y298 PhosphoSitePlus 22727666
Q16555 (DPYSL2) Y479 PhosphoSitePlus 19276087
Q8TEW0 (PARD3) Y1127 neXtProt 17053785
Q969T9 (WBP2) Y192 PhosphoSitePlus 21642474
Q969T9 (WBP2) Y231 PhosphoSitePlus 21642474

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P09619 (PDGFRB) Y579 P07947 (YES1) unknown eFIP 7685273
Phosphorylation P09917 (ALOX5) S53 P07947 (YES1) unknown eFIP 24860872
Phosphorylation P36888 (FLT3) Y726 P07947 (YES1) unknown eFIP 28086240
Phosphorylation Q08345 (DDR1) Y586 P07947 (YES1) unknown eFIP 22057045
Phosphorylation Q8IZP0 (ABI1) Y421 P07947 (YES1) unknown eFIP 20598684

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S40 P40 Biomuta DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]
S44 * Biomuta DOID:3571 / liver cancer [ icgc ]
S45 F45 Biomuta DOID:263 / kidney cancer [ cosmic, icgc, tcga ]
S46 L46 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
Y159 F159 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y223 S223 Biomuta DOID:1324 / lung cancer [ tcga ]
Y223 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
Y336 C336 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y345 S345 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
Y426 N426 Biomuta DOID:2531 / hematologic cancer [ tcga ]
Y489 C489 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]