iPTMnet Report P07947 YES1

Protein Information

UniProt AC / UniProt ID	P07947 / YES_HUMAN
Protein Name	Tyrosine-protein kinase Yes
Gene Name	Name: YES1 Synonyms:YES;
Organism	Homo sapiens (Human)

PRO ID	PR:P07947 DAG View
PRO Name	tyrosine-protein kinase Yes (human)
Definition	A tyrosine-protein kinase Yes that is encoded in the genome of human.
Short Label	hYES1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P07947 (YES1) as Substrate

P07947

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S11	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
K15	Ubiquitination		score1	PhosphoSitePlus
Y16	Phosphorylation		score1	PhosphoSitePlus
T21	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	18691976, 18669648
S26	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
T27	Phosphorylation		score0	HPRD	18691976
S28	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
S30	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
Y32	Phosphorylation	P07947 (YES1)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus	18083107, 9058199
T37	Phosphorylation		score1	PhosphoSitePlus
T38	Phosphorylation		score1	PhosphoSitePlus
S40	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	18691976, 18669648
S44	Phosphorylation		score2	HPRD phospho.ELM	18669648
S45	Phosphorylation		score2	HPRD PhosphoSitePlus	18669648
S46	Phosphorylation		score1	PhosphoSitePlus
Y100	Phosphorylation		score1	PhosphoSitePlus
S111	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
K138	Ubiquitination		score1	PhosphoSitePlus
Y141	Phosphorylation		score1	PhosphoSitePlus
S144	Phosphorylation		score1	PhosphoSitePlus
Y146	Phosphorylation		score1	PhosphoSitePlus
Y159	Phosphorylation		score1	PhosphoSitePlus
S187	Phosphorylation		score1	PhosphoSitePlus
T190	Phosphorylation		score1	PhosphoSitePlus
K191	Ubiquitination		score1	PhosphoSitePlus
Y194	Phosphorylation		score2	HPRD PhosphoSitePlus	18669648
S195	Phosphorylation		score2	HPRD PhosphoSitePlus	18691976
S197	Phosphorylation		score1	PhosphoSitePlus
Y222	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18083107
Y223	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18083107
T226	Phosphorylation		score1	PhosphoSitePlus
K235	Ubiquitination		score1	PhosphoSitePlus
K238	Ubiquitination		score1	PhosphoSitePlus
K250	Ubiquitination		score1	PhosphoSitePlus
K259	Ubiquitination		score1	PhosphoSitePlus
T262	Phosphorylation		score1	PhosphoSitePlus
K267	Ubiquitination		score1	PhosphoSitePlus
S276	Phosphorylation		score1	PhosphoSitePlus
K325	Ubiquitination		score1	PhosphoSitePlus
Y336	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
Y345	Phosphorylation		score2	PhosphoSitePlus UniProt	19369195
S355	Phosphorylation		score1	PhosphoSitePlus
K361	Ubiquitination		score1	PhosphoSitePlus
Y426	Phosphorylation	P07947 (YES1)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	19651622, 9058199, 17081983, ...16094384, 9794236, 17192257, 18083107, 18691976, 18669648, 18707149
T427	Phosphorylation		score1	PhosphoSitePlus
K433	Ubiquitination		score1	PhosphoSitePlus
K437	Ubiquitination		score1	PhosphoSitePlus
Y446	Phosphorylation		score2	HPRD phospho.ELM PhosphoSitePlus	18083107
K468	Ubiquitination		score1	PhosphoSitePlus
Y489	Phosphorylation		score1	PhosphoSitePlus
K510	Ubiquitination		score1	PhosphoSitePlus
T531	Phosphorylation		score1	PhosphoSitePlus
T533	Phosphorylation		score1	PhosphoSitePlus
Y537	Phosphorylation	P41240 (CSK)	score4	HPRD phospho.ELM PhosphoSitePlus UniProt	19369195, 18691976, 7690925, ...16439366, 18083107

P07947 (YES1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P07947 (YES1)	Y32	score2	neXtProt	9058199
P07947 (YES1)	Y426	score4	HPRD neXtProt Signor UniProt	18691976, 9058199, 17081983, ...9794236, 19651622, 18669648, 18707149
P11802 (CDK4)	Y17	score3	neXtProt PhosphoSitePlus Signor	18479465
P15529-7 (CD46)	Y324	score1	HPRD	11901164
P15529-12 (CD46)	Y338	score1	HPRD	11901164
P15529-11 (CD46)	Y353	score1	HPRD	11901164
P15529-4 (CD46)	Y354	score2	neXtProt	11901164
P15529-1 (CD46)	Y368	score1	HPRD	11901164
P46527 (CDKN1B)	Y74	score3	HPRD neXtProt PhosphoSitePlus	17254967
P46527 (CDKN1B)	Y88	score3	HPRD neXtProt PhosphoSitePlus	17254967
P46527 (CDKN1B)	Y89	score3	neXtProt PhosphoSitePlus	17254967
Q05397 (PTK2)	Y576	score2	neXtProt	16293639
Q05397 (PTK2)	Y861	score2	PhosphoSitePlus	25868388
Q05397 (PTK2)	Y925	score2	PhosphoSitePlus	25868388
Q05655 (PRKCD)	Y313	score2	neXtProt	18387943
Q05655 (PRKCD)	Y334	score2	neXtProt	18387943
Q16543 (CDC37)	Y298	score2	PhosphoSitePlus	22727666
Q16555 (DPYSL2)	Y479	score2	PhosphoSitePlus	19276087
Q8TEW0 (PARD3)	Y1127	score2	neXtProt	17053785
Q969T9 (WBP2)	Y192	score3	PhosphoSitePlus Signor	21642474
Q969T9 (WBP2)	Y231	score3	PhosphoSitePlus Signor	21642474

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
S11	R11	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
S26	G26	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S40	P40	Biomuta	DOID:1319 / brain cancer [ cosmic, icgc ]
S40	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
S44	L44	Biomuta	DOID:4159 / skin cancer [ cosmic ]
S45	F45	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
S46	L46	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
S111	L111	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
Y159	C159	Biomuta	DOID:1324 / lung cancer [ cosmic ]
Y159	F159	Biomuta	DOID:1612 / breast cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S195	F195	Biomuta	DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S195	P195	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S197	F197	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y223	S223	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
Y223	*	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
Y336	C336	Biomuta	DOID:3571 / liver cancer [ cosmic ]
Y345	S345	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc ]
Y489	C489	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T533	A533	Biomuta	DOID:1324 / lung cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P07947 (YES1)

Protein Information

Interactive Sequence View

P07947 (YES1) as Substrate

P07947 (YES1) as PTM Enzyme

PTM sites affected in variants