iPTMnet Report for P07910 (HNRNPC)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07910 / HNRPC_HUMAN
Protein Name Heterogeneous nuclear ribonucleoproteins C1/C2
Gene Name Name: HNRNPC
Synonyms:HNRPC;
Organism Homo sapiens (Human)

PRO ID PR:P07910
DAG View
PRO Name heterogeneous nuclear ribonucleoproteins C1/C2 (human)
Definition A heterogeneous nuclear ribonucleoproteins C1/C2 that is encoded in the genome of human.
Short Label hHNRNPC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07910 (HNRNPC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378
S3 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 34725712, 21740066, 34019948, 35083852, 20305658, 32119511, 28510447, 22121020, 33465208
S3 Phosphorylation PhosphoSitePlus
K8 Acetylation PhosphoSitePlus
K8 Sumoylation PhosphoSitePlus
K8 Ubiquitination PhosphoSitePlus
T9 Phosphorylation PhosphoSitePlus
K29 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S31 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...32522876, 34725712, 21740066, 34019948, 35083852, 20305658, 32119511, 28510447, 22121020, 33465208
S31 Phosphorylation PhosphoSitePlus
S38 Phosphorylation PhosphoSitePlus
K39 Acetylation PhosphoSitePlus
K39 Methylation PhosphoSitePlus
K39 Sumoylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
K42 Sumoylation PhosphoSitePlus
K42 Ubiquitination PhosphoSitePlus
C46 Methylation IEDB 31844290
S47 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Sumoylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
Y57 Phosphorylation PhosphoSitePlus   RLIMS-P 18494499
R61 Methylation PhosphoSitePlus
K89 Sumoylation PhosphoSitePlus
K89 Ubiquitination PhosphoSitePlus
K98 Methylation PhosphoSitePlus
S100 Phosphorylation phospho.ELM 18669648
Y105 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S107 Phosphorylation PhosphoSitePlus   UniProt 18669648, 21406692
V108 Phosphorylation UniProt 18669648
T109 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
S113 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 31364055, 18669648, 19690332
S115 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332, 24275569
S119 Phosphorylation PhosphoSitePlus
S120 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S121 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y126 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
Y133 Phosphorylation PhosphoSitePlus
R135 Methylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
S138 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
Y139 Phosphorylation PhosphoSitePlus
R142 Methylation PhosphoSitePlus
R151 Methylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
R160 Methylation PhosphoSitePlus
S162 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983
T165 Phosphorylation PhosphoSitePlus
S166 Phosphorylation PhosphoSitePlus   UniProt 21406692
K170 Acetylation PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
K176 Sumoylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K187 Acetylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K189 Methylation PhosphoSitePlus
K189 Sumoylation PhosphoSitePlus
K189 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K198 Ubiquitination PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K206 Acetylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K229 Sumoylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K232 Acetylation PhosphoSitePlus
K232 Sumoylation PhosphoSitePlus
K232 Ubiquitination PhosphoSitePlus
S233 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18318008, 18669648, 24275569, 17287340, 19690332, 20068231
S238 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18669648, 17287340, ...24275569
S239 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340, 24275569
S240 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 12564933, 17287340
S241 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18669648, 23186163, ...21406692
K243 Sumoylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
T247 Phosphorylation PhosphoSitePlus
K250 Sumoylation PRO   PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
S253 Phosphorylation P48729 (CSNK1A1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 17287340, ...17081983, 15687492, 12564933, 18318008, 18669648, 24275569, 23186163, 19690332
S260 Phosphorylation P68400 (CSNK2A1) , P48729 (CSNK1A1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 21406692, 23186163, ...17081983, 15687492, 12564933, 15302935, 18318008, 18669648, 24275569, 17693683, 17287340, 19690332, 20068231
K284 Ubiquitination PhosphoSitePlus
S299 Phosphorylation P48729 (CSNK1A1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 17081983, 15687492, ...16807684, 12564933, 15302935, 18318008, 19367720, 18669648, 20068231
S306 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 21406692, ...18318008
Site PTM Type PTM Enzyme Score Source PMID
S100 Phosphorylation HPRD 18669648
S107 Phosphorylation HPRD 20068231
T109 Phosphorylation HPRD 18669648
S113 Phosphorylation HPRD 18669648, 20068231
S115 Phosphorylation HPRD 18669648, 20068231, 18452278
S119 Phosphorylation HPRD 20068231
S138 Phosphorylation HPRD 17287340, 18212344
S156 Phosphorylation HPRD 20068231
S162 Phosphorylation HPRD 17081983, 20068231
S175 Phosphorylation HPRD 20068231
S183 Phosphorylation HPRD 20068231
S233 Phosphorylation HPRD 17287340, 17081983, 19651622, ...18669648, 20166139, 20068231, 18212344
S238 Phosphorylation HPRD 18669648, 17287340, 20068231
S239 Phosphorylation HPRD 18669648, 17287340, 17081983, ...20068231
S240 Phosphorylation HPRD 18669648, 17287340, 17081983
S241 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
T247 Phosphorylation HPRD 19651622
S253 Phosphorylation P48729 (CSNK1A1) HPRD 18691976, 17287340, 17081983, ...15687492, 20058876, 19664995, 18452278, 19651622, 18669648, 20166139, 20068231
S260 Phosphorylation P19784 (CSNK2A2) , P68400 (CSNK2A1) HPRD 19413330, 18691976, 17287340, ...12564933, 20058876, 19664995, 18452278, 19651622, 17322306, 18669648, 17693683, 20166139, 20068231
S299 Phosphorylation HPRD 18491316, 18212344, 12564933, ...15302935, 18452278, 19651622, 18669648, 20166139, 20068231, 17081983
S306 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
K98 Sumoylation PhosphoSitePlus
R99 Methylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation HPRD   PhosphoSitePlus 18669648
S107 Phosphorylation HPRD   PhosphoSitePlus 18669648
S108 Phosphorylation HPRD   PhosphoSitePlus 18669648
Y113 Phosphorylation PhosphoSitePlus
R117 Methylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
S125 Phosphorylation HPRD   PhosphoSitePlus 17287340, 18212344
S143 Phosphorylation HPRD 20068231
S149 Phosphorylation HPRD 17081983, 20068231
S162 Phosphorylation HPRD 20068231
S170 Phosphorylation HPRD 20068231
S220 Phosphorylation HPRD 17287340, 17081983, 19651622, ...18669648, 20166139, 20068231, 18212344
S225 Phosphorylation HPRD 18669648, 17287340, 20068231
S226 Phosphorylation HPRD 18669648, 17287340, 17081983, ...20068231
S227 Phosphorylation HPRD   phospho.ELM 18669648, 17287340, 17081983
S228 Phosphorylation HPRD 19651622, 18669648, 17287340, ...17081983, 20068231
T234 Phosphorylation HPRD 19651622
K237 Sumoylation PhosphoSitePlus
S240 Phosphorylation P48729 (CSNK1A1) HPRD 18691976, 17287340, 17081983, ...15687492, 20058876, 19664995, 18452278, 19651622, 18669648, 20166139, 20068231
S247 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD 19413330, 18691976, 17287340, ...12564933, 20058876, 19664995, 18452278, 19651622, 17322306, 18669648, 17693683, 20166139, 20068231
S286 Phosphorylation HPRD 18491316, 18212344, 12564933, ...15302935, 18452278, 19651622, 18669648, 20166139, 20068231, 17081983
S293 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
R99 Methylation PhosphoSitePlus
S100 Phosphorylation PhosphoSitePlus
Y105 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S108 Phosphorylation PhosphoSitePlus
Y113 Phosphorylation PhosphoSitePlus
R117 Methylation PhosphoSitePlus
Y119 Phosphorylation PhosphoSitePlus
Y120 Phosphorylation PhosphoSitePlus
Y124 Phosphorylation PhosphoSitePlus
S125 Phosphorylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047886 (hHNRNPC/InitMet-/Sumo:1) suK250 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K29 N29 Biomuta DOID:1319 / brain cancer [ cosmic ]
S38 L38 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic ]
S100 Y100 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y105 C105 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S107 F107 Biomuta DOID:4159 / skin cancer [ cosmic ]
T109 P109 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
R117 L117 Biomuta DOID:2021 / placenta cancer [ cosmic ]
S120 F120 Biomuta DOID:4159 / skin cancer [ cosmic ]
R135 W135 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y139 F139 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
R142 C142 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
R142 H142 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S143 L143 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R151 L151 Biomuta DOID:3571 / liver cancer [ cosmic ]
R151 Q151 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S156 L156 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R160 C160 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K170 N170 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K176 N176 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K206 N206 Biomuta DOID:1324 / lung cancer [ cosmic ]
S209 F209 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
S209 Y209 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
S220 T220 Biomuta DOID:3571 / liver cancer [ cosmic ]
S220 P220 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S227 A227 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S228 F228 Biomuta [ cosmic ]
S233 P233 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S233 T233 Biomuta DOID:3571 / liver cancer [ cosmic ]
S240 A240 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S241 F241 Biomuta [ cosmic ]
S286 R286 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic ] DOID:2021 / placenta cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S299 R299 Biomuta DOID:363 / uterine cancer [ cosmic ]