Protein Information

Cytoscape View


UniProt AC / UniProt ID P07900 / HS90A_HUMAN
Protein Name Heat shock protein HSP 90-alpha
Gene Name Name: HSP90AA1
Synonyms:HSP90A,HSPC1,HSPCA;
Organism Homo sapiens (Human)

PRO ID PR:P07900
DAG View
PRO Name heat shock protein HSP 90-alpha (human)
Definition A heat shock protein HSP 90-alpha that is encoded in the genome of human.
Short Label hHSP90AA1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07900 (HSP90AA1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25423885, 2507541
T7 Phosphorylation P78527 (PRKDC) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25423885, 26010604, 2507541
T36 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 21419342
Y38 Phosphorylation P30291 (WEE1) PhosphoSitePlus 20159553
K41 Acetylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
S53 Phosphorylation PhosphoSitePlus
K58 Acetylation PhosphoSitePlus
K58 Ubiquitination PhosphoSitePlus
Y61 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
T65 Phosphorylation PhosphoSitePlus
S68 Phosphorylation PhosphoSitePlus
K69 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K74 Acetylation PhosphoSitePlus
K74 Sumoylation PhosphoSitePlus
K74 Ubiquitination PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
T88 Phosphorylation PhosphoSitePlus
T90 Phosphorylation P17612 (PRKACA) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 21919888, 19965370
T94 Phosphorylation PhosphoSitePlus
T99 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T109 Phosphorylation PhosphoSitePlus
K112 Ubiquitination PhosphoSitePlus
S113 Phosphorylation PhosphoSitePlus
T115 Phosphorylation P05129 (PRKCG) , P33981 (TTK) PhosphoSitePlus   Signor 26804907, 24117238
K116 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
Y160 Phosphorylation PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus   RLIMS-P 29209046
S169 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K191 Acetylation PhosphoSitePlus
K191 Methylation PhosphoSitePlus
K191 Sumoylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T195 Phosphorylation PhosphoSitePlus
Y197 Phosphorylation PhosphoSitePlus   RLIMS-P 22727666, 29343704
R201 Methylation PhosphoSitePlus
K204 Sumoylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K209 Acetylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S211 Phosphorylation PhosphoSitePlus
Y216 Phosphorylation PhosphoSitePlus
T219 Phosphorylation PhosphoSitePlus
K224 Acetylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S231 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 17287340, 18088087, 17081983, ...18318008, 2492519, 24275569, 23186163, 15822905
K238 Ubiquitination PhosphoSitePlus
K245 Ubiquitination PhosphoSitePlus
S252 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18088087, 21406692, 23186163, ...17081983
K255 Ubiquitination PhosphoSitePlus
S263 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 18691976, 18088087, 17081983, ...16807684, 18318008, 19367720, 18669648, 17287340, 2492519, 23186163, 15822905
K274 Acetylation PhosphoSitePlus
K276 Acetylation PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
K283 Acetylation PhosphoSitePlus
K283 Methylation PhosphoSitePlus
K283 Ubiquitination PhosphoSitePlus
Y284 Phosphorylation PhosphoSitePlus
K292 Acetylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
K294 Methylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
R299 Methylation PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
Y309 Phosphorylation PhosphoSitePlus
Y313 Phosphorylation PhosphoSitePlus   RLIMS-P 22727666, 31189925, 29343704
K314 Acetylation PhosphoSitePlus
K314 Sumoylation PhosphoSitePlus
K314 Ubiquitination PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
T317 Phosphorylation PhosphoSitePlus
K327 Acetylation PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
R345 Methylation PhosphoSitePlus
R355 Methylation PhosphoSitePlus
K357 Sumoylation PhosphoSitePlus
K358 Sumoylation PhosphoSitePlus
K358 Ubiquitination PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
S391 Phosphorylation Q6P2M8 (PNCK) PhosphoSitePlus 21325639
S399 Phosphorylation PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
K407 Acetylation PhosphoSitePlus
K407 Sumoylation PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K410 Acetylation PhosphoSitePlus
K419 Acetylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
C420 S-Nitrosylation dbSNO 20140087, 22178444
T425 Phosphorylation P05129 (PRKCG) PhosphoSitePlus   Signor 24117238
K431 Acetylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
Y434 Phosphorylation PhosphoSitePlus
K435 Acetylation PhosphoSitePlus
K436 Acetylation PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
S442 Phosphorylation PhosphoSitePlus
K443 Acetylation PhosphoSitePlus   UniProt 19608861
K443 Methylation PhosphoSitePlus
K443 Ubiquitination PhosphoSitePlus
K446 Acetylation PhosphoSitePlus
K446 Ubiquitination PhosphoSitePlus
S453 Phosphorylation PhosphoSitePlus
K457 Acetylation PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K458 Acetylation PhosphoSitePlus   UniProt 19608861
K458 Ubiquitination PhosphoSitePlus
S460 Phosphorylation PhosphoSitePlus
R464 Methylation PhosphoSitePlus
Y465 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
S468 Phosphorylation PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus   UniProt 23186163
K478 Acetylation PhosphoSitePlus
K478 Ubiquitination PhosphoSitePlus
Y480 Phosphorylation PhosphoSitePlus
C481 S-Nitrosylation dbSNO 22178444, 17629318
T482 Phosphorylation PhosphoSitePlus
K485 Acetylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K489 Acetylation PhosphoSitePlus   UniProt 19608861
K489 Methylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
Y492 Phosphorylation PhosphoSitePlus
Y493 Phosphorylation PhosphoSitePlus
T498 Phosphorylation PhosphoSitePlus
K499 Acetylation PhosphoSitePlus
K499 Ubiquitination PhosphoSitePlus
S505 Phosphorylation PhosphoSitePlus
R510 Methylation PhosphoSitePlus
K513 Acetylation PhosphoSitePlus
K513 Methylation PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
Y528 Phosphorylation PhosphoSitePlus
K534 Acetylation PhosphoSitePlus
K539 Acetylation PhosphoSitePlus
K539 Sumoylation PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
T540 Phosphorylation PhosphoSitePlus
S543 Phosphorylation PhosphoSitePlus
K546 Acetylation PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
K558 Acetylation PhosphoSitePlus
K558 Ubiquitination PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
K565 Ubiquitination PhosphoSitePlus
T566 Phosphorylation PhosphoSitePlus
K567 Acetylation PhosphoSitePlus
K567 Ubiquitination PhosphoSitePlus
K573 Acetylation PhosphoSitePlus
K573 Methylation PhosphoSitePlus
K573 Ubiquitination PhosphoSitePlus
K576 Acetylation PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
K581 Acetylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
K582 Ubiquitination PhosphoSitePlus
K585 Acetylation PhosphoSitePlus   UniProt 19608861
K585 Ubiquitination PhosphoSitePlus
S589 Phosphorylation PhosphoSitePlus
S595 Phosphorylation PhosphoSitePlus   RLIMS-P 24962213
C597 S-Nitrosylation dbSNO 22178444, 15937123
C598 S-Nitrosylation dbSNO 22178444, 15937123
T601 Phosphorylation PhosphoSitePlus
S602 Phosphorylation PhosphoSitePlus
T603 Phosphorylation P05129 (PRKCG) PhosphoSitePlus   Signor 24117238
Y604 Phosphorylation PhosphoSitePlus
T607 Phosphorylation PhosphoSitePlus
K615 Acetylation PhosphoSitePlus
K615 Methylation PhosphoSitePlus
K615 Ubiquitination PhosphoSitePlus
S623 Phosphorylation PhosphoSitePlus
T624 Phosphorylation Q6P2M8 (PNCK) PhosphoSitePlus 21325639
Y627 Phosphorylation PhosphoSitePlus   RLIMS-P 22727666, 29343704
K631 Acetylation PhosphoSitePlus
K631 Ubiquitination PhosphoSitePlus
K632 Acetylation PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
S641 Phosphorylation PhosphoSitePlus   UniProt 23186163
T645 Phosphorylation PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
T669 Phosphorylation PhosphoSitePlus
Y689 Phosphorylation PhosphoSitePlus
T704 Phosphorylation PhosphoSitePlus
T708 Phosphorylation PhosphoSitePlus
S709 Phosphorylation PhosphoSitePlus
T725 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S726 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
T5 Phosphorylation P78527 (PRKDC) HPRD 2507541
T7 Phosphorylation P78527 (PRKDC) HPRD 2507541
T88 Phosphorylation HPRD 17287340
T90 Phosphorylation HPRD 17287340
S231 Phosphorylation P68400 (CSNK2A1) HPRD 18088087, 18767875, 18452278, ...19651622, 18510355, 2492519, 20166139, 17287340, 20068231
S252 Phosphorylation HPRD 18578522, 18088087, 17081983, ...20230923, 18452278, 19651622, 18707149, 20068231
S263 Phosphorylation P68400 (CSNK2A1) HPRD 19413330, 18691976, 18088087, ...18212344, 18767875, 18452278, 19651622, 18510355, 18669648, 20187088, 2492519, 18707149, 20166139, 17287340, 19415658, 20068231
S315 Phosphorylation HPRD 19651622
S589 Phosphorylation HPRD 20068231
S641 Phosphorylation HPRD 19651622
Y667 Phosphorylation HPRD 20068231
S673 Phosphorylation HPRD 20068231
S674 Phosphorylation HPRD 20068231
S677 Phosphorylation HPRD 20068231
T683 Phosphorylation HPRD 20068231
T704 Phosphorylation HPRD 18452278
T708 Phosphorylation HPRD 18452278
S709 Phosphorylation HPRD 18452278
T725 Phosphorylation HPRD 18669648, 20068231, 18452278
S726 Phosphorylation HPRD 18669648, 18452278
Site PTM Type PTM Enzyme Score Source PMID
S73 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
T127 Phosphorylation P78527 (PRKDC) HPRD 2507541
T129 Phosphorylation P78527 (PRKDC) HPRD 2507541
Y183 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
T210 Phosphorylation HPRD 17287340
T212 Phosphorylation HPRD 17287340
S353 Phosphorylation P68400 (CSNK2A1) HPRD 18088087, 18767875, 18452278, ...19651622, 18510355, 2492519, 20166139, 17287340, 20068231
S374 Phosphorylation HPRD 18578522, 18088087, 17081983, ...20230923, 18452278, 19651622, 18707149, 20068231
S385 Phosphorylation P68400 (CSNK2A1) HPRD 19413330, 18691976, 18088087, ...18212344, 18767875, 18452278, 19651622, 18510355, 18669648, 20187088, 2492519, 18707149, 20166139, 17287340, 19415658, 20068231
Y406 Phosphorylation PhosphoSitePlus
S437 Phosphorylation HPRD 19651622
K449 Acetylation PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
T589 Phosphorylation PhosphoSitePlus
T604 Phosphorylation PhosphoSitePlus
K607 Acetylation PhosphoSitePlus
Y614 Phosphorylation PhosphoSitePlus
Y615 Phosphorylation PhosphoSitePlus
K656 Acetylation PhosphoSitePlus
S711 Phosphorylation HPRD 20068231
Y726 Phosphorylation PhosphoSitePlus
K753 Acetylation PhosphoSitePlus
S763 Phosphorylation HPRD 19651622
Y789 Phosphorylation HPRD 20068231
S795 Phosphorylation HPRD 20068231
S796 Phosphorylation HPRD 20068231
S799 Phosphorylation HPRD 20068231
T805 Phosphorylation HPRD 20068231
T826 Phosphorylation HPRD 18452278
T830 Phosphorylation HPRD 18452278
S831 Phosphorylation HPRD 18452278
T847 Phosphorylation HPRD 18669648, 20068231, 18452278
S848 Phosphorylation HPRD 18669648, 18452278


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O95433 (AHSA1) Y223 P07900 (HSP90AA1) increased_association eFIP 29127155
Phosphorylation P07900 (HSP90AA1) Y197 P19838 (NFKB1) inhibited_association eFIP 22727666
Phosphorylation P07900 (HSP90AA1) S164 Q9UBU7 (DBF4) unknown eFIP 29209046
Phosphorylation P07900 (HSP90AA1) Y197 Q16543 (CDC37) unknown eFIP 29343704
Phosphorylation P07900 (HSP90AA1) Y313 O95433 (AHSA1) decreased_association eFIP 31189925
Phosphorylation P07900 (HSP90AA1) S164 O00311 (CDC7) unknown eFIP 29209046
Phosphorylation P31749 (AKT1) S473 P07900 (HSP90AA1) unknown eFIP 25935150
Phosphorylation P31749 (AKT1) S129 P07900 (HSP90AA1) unknown eFIP 19662498
Phosphorylation Q00613 (HSF1) S121 P07900 (HSP90AA1) increased_association eFIP 16278218
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 17922836
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 12930845
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 25619116
Phosphorylation Q16543 (CDC37) S13 P07900 (HSP90AA1) unknown eFIP 21871133


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000025723 (hHSF1/iso:Long/Phos:1) Interaction PR:P07900 (hHSP90AA1) PRO 16278218


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S53 * Biomuta DOID:1324 / lung cancer [ tcga ]
K58 T58 Biomuta DOID:2994 / germ cell cancer [ cosmic ]
T65 K65 Biomuta DOID:3571 / liver cancer [ icgc ]
T94 N94 Biomuta DOID:363 / uterine cancer [ tcga ]
T99 A99 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S164 Y164 Biomuta DOID:3571 / liver cancer [ icgc ]
Y197 C197 Biomuta DOID:263 / kidney cancer [ tcga ]
R201 G201 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S211 F211 Biomuta DOID:1324 / lung cancer [ tcga ]
Y216 H216 Biomuta DOID:3571 / liver cancer [ tcga ]
K245 E245 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K276 N276 Biomuta DOID:1612 / breast cancer [ tcga ]
K283 T283 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R299 S299 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R355 K355 Biomuta DOID:363 / uterine cancer [ tcga ]
K358 N358 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S391 L391 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
S399 T399 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y434 C434 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S453 C453 Biomuta DOID:1612 / breast cancer [ cosmic ]
S470 C470 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y480 H480 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
C481 G481 Biomuta DOID:1324 / lung cancer [ cosmic ]
K485 E485 Biomuta DOID:263 / kidney cancer [ tcga ]
K499 N499 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S505 * Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R510 L510 Biomuta DOID:1115 / sarcoma [ tcga ]
S543 * Biomuta DOID:3571 / liver cancer [ icgc ]
K558 R558 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K576 T576 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
K581 T581 Biomuta DOID:363 / uterine cancer [ tcga ]
S589 * Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
S595 F595 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y604 H604 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T607 A607 Biomuta DOID:2394 / ovarian cancer [ tcga ]
S623 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
T624 K624 Biomuta DOID:3571 / liver cancer [ icgc ]
S641 C641 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T708 A708 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T725 I725 Biomuta DOID:3571 / liver cancer [ icgc ]
S726 L726 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]