iPTMnet Report for P07858 (CTSB)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07858 / CATB_HUMAN
Protein Name Cathepsin B precursor
Gene Name Name: CTSB
Synonyms:CPSB;
Organism Homo sapiens (Human)

PRO ID PR:P07858
DAG View
PRO Name cathepsin B (human)
Definition A cathepsin B that is encoded in the genome of human.
Short Label hCTSB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07858 (CTSB) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y33 Phosphorylation PhosphoSitePlus
N38 N-Glycosylation GlyGen 23090970, 32125861, 24190977
S169 Phosphorylation PhosphoSitePlus
Y173 Phosphorylation PhosphoSitePlus
N192 N-Glycosylation GlyGen   UniProt 23090970, 24190977, 3463996
S194 O-Glycosylation GlyGen 34019948, 34725712, 35254053
C211 S-Nitrosylation dbSNO 2212679, 22126794
Y215 Phosphorylation PhosphoSitePlus
Y219 Phosphorylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K237 Ubiquitination PhosphoSitePlus
Y244 Phosphorylation PhosphoSitePlus
C319 S-Nitrosylation dbSNO 25040305


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y33 H33 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
N38 T38 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S194 C194 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K223 R223 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K237 N237 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K237 T237 Biomuta DOID:10534 / stomach cancer [ cosmic ]