iPTMnet Report for P07814 (EPRS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07814 / SYEP_HUMAN
Protein Name Bifunctional glutamate/proline--tRNA ligase
Gene Name Name: EPRS1
Synonyms:EPRS,GLNS,PARS,QARS,QPRS;ORFNames:PIG32;
Organism Homo sapiens (Human)

PRO ID PR:P07814
DAG View
PRO Name bifunctional glutamate/proline--tRNA ligase (human)
Definition A bifunctional glutamate/proline--tRNA ligase that is encoded in the genome of human.
Short Label hEPRS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07814 (EPRS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S29 Phosphorylation PhosphoSitePlus
Y57 Phosphorylation IEDB 35494241
T64 Phosphorylation PhosphoSitePlus
C92 S-Nitrosylation dbSNO 19483679
C105 Methylation IEDB 31844290
C105 S-Nitrosylation dbSNO 19483679
K139 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
Y224 Phosphorylation PhosphoSitePlus
K229 Methylation PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
K231 Methylation PhosphoSitePlus
K243 Acetylation PhosphoSitePlus
K245 Acetylation PhosphoSitePlus
M277 Methylation IEDB 25880248
K282 Acetylation PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K300 Acetylation PhosphoSitePlus   UniProt 19608861
K300 Ubiquitination PhosphoSitePlus
K318 Sumoylation PhosphoSitePlus
K328 Methylation PhosphoSitePlus
K328 Ubiquitination PhosphoSitePlus
S330 Phosphorylation PhosphoSitePlus
S335 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
T355 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y357 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
K417 Acetylation PhosphoSitePlus   UniProt 19608861
K417 Ubiquitination PhosphoSitePlus
Y423 Phosphorylation PhosphoSitePlus
S434 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17322306, 18767875, 23186163, ...20068231
K435 Ubiquitination PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
R454 Methylation PhosphoSitePlus
R464 Methylation PhosphoSitePlus
T467 Phosphorylation PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K497 Acetylation PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K498 Acetylation PhosphoSitePlus   UniProt 19608861
K498 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K528 Acetylation PhosphoSitePlus
K535 Acetylation PhosphoSitePlus   UniProt 19608861
K535 Ubiquitination PhosphoSitePlus
K542 Acetylation PhosphoSitePlus   UniProt 19608861
K542 Ubiquitination PhosphoSitePlus
Y546 Phosphorylation PhosphoSitePlus
S547 Phosphorylation PhosphoSitePlus
K581 Ubiquitination PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
K593 Ubiquitination PhosphoSitePlus
K599 Acetylation PhosphoSitePlus
K599 Ubiquitination PhosphoSitePlus
T613 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 27655845, 30379171, 34725712, 26853435, 34019948, 21740066, 29351928, 35132862, 35083852, 32870666, 20305658, 32119511, 28510447, 33465208
T631 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 27655845, 30379171, 34725712, 26853435, 34019948, 21740066, 29351928, 35132862, 35083852, 32870666, 20305658, 32119511, 28510447, 33465208
K637 Acetylation PhosphoSitePlus   UniProt 19608861
K642 Ubiquitination PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
Y684 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
Y690 Phosphorylation PhosphoSitePlus
S691 Phosphorylation PhosphoSitePlus
C697 Methylation IEDB 31844290
K708 Ubiquitination PhosphoSitePlus
S713 Phosphorylation HPRD   PhosphoSitePlus 20068231
K718 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K725 Ubiquitination PhosphoSitePlus
T728 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 27655845, 30379171, 34725712, 26853435, 34019948, 21740066, 29351928, 35132862, 35083852, 32870666, 20305658, 32119511, 28510447, 33465208
K733 Ubiquitination PhosphoSitePlus
S739 Phosphorylation PhosphoSitePlus
T745 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 27655845, 30379171, 34725712, 26853435, 34019948, 21740066, 29351928, 35132862, 35083852, 32870666, 20305658, 32119511, 28510447, 33465208
T745 Phosphorylation PhosphoSitePlus
T746 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 27655845, 30379171, 34725712, 26853435, 34019948, 21740066, 29351928, 35132862, 35083852, 32870666, 20305658, 32119511, 28510447, 33465208
T746 Phosphorylation PhosphoSitePlus
S747 Phosphorylation PhosphoSitePlus   UniProt 23186163
S750 Phosphorylation PhosphoSitePlus
Y754 Phosphorylation PhosphoSitePlus
K782 Ubiquitination PhosphoSitePlus
K788 Acetylation PhosphoSitePlus   UniProt 19608861
S813 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648, 17287340
S814 Phosphorylation phospho.ELM 18669648, 17287340, 18220336
S816 Phosphorylation PhosphoSitePlus
S817 Phosphorylation PhosphoSitePlus
S819 Phosphorylation phospho.ELM 18669648, 17287340
S825 Phosphorylation PhosphoSitePlus
Y827 Phosphorylation PhosphoSitePlus
S845 Phosphorylation HPRD   PhosphoSitePlus 20068231
K849 Ubiquitination PhosphoSitePlus
C856 S-Nitrosylation dbSNO 19483679, 22178444
S859 Phosphorylation PhosphoSitePlus
K861 Acetylation PhosphoSitePlus
K861 Ubiquitination PhosphoSitePlus
Y864 Phosphorylation PhosphoSitePlus
Y872 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S880 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983, 20058876, ...19651622, 18669648, 20068231
S882 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 23186163, 17081983, ...18691976, 20230923, 19664995, 19651622, 18669648, 19690332, 18212344
S883 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983, 20230923, ...19664995, 18669648, 19415658, 20068231, 18212344
S885 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18491316, 17287340, ...17081983, 18691976, 20230923, 20058876, 19664995, 18669648, 19415658, 20068231
S886 Phosphorylation HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18578522, 18691976, 21406692, ...19647514, 23186163, 20230923, 18452278, 21220307, 23071094, 19690332, 19413330, 20058876, 19651622, 18491316, 17287340, 19664994, 19664995, 17322306, 18669648, 19415658, 20068231, 17924679
S886 Phosphorylation Q00535 (CDK5) PhosphoSitePlus   Signor 19647514, 21220307, 23071094
T888 Phosphorylation HPRD   PhosphoSitePlus 19413330, 17081983, 18452278, ...19651622, 18669648, 20068231
S891 O-Glycosylation GlyGen 31373491
S891 Phosphorylation HPRD   PhosphoSitePlus   UniProt 17287340, 17081983, 19651622, ...18669648, 19690332, 20068231
T898 O-Glycosylation GlyGen 31373491
T898 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 16964243, 15302935, ...18669648, 20068231
K902 Ubiquitination PhosphoSitePlus
K907 Ubiquitination PhosphoSitePlus
S910 Phosphorylation PhosphoSitePlus 21851590
S910 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
K925 Ubiquitination PhosphoSitePlus
K939 Ubiquitination PhosphoSitePlus
K943 Ubiquitination PhosphoSitePlus
S944 Phosphorylation PhosphoSitePlus
Y950 Phosphorylation PhosphoSitePlus
K951 Acetylation PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
K980 Ubiquitination PhosphoSitePlus
S990 Phosphorylation PhosphoSitePlus
K991 Methylation PhosphoSitePlus
K991 Ubiquitination PhosphoSitePlus
S998 Phosphorylation PhosphoSitePlus   UniProt 23186163
S999 Phosphorylation HPRD   PRO   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 19647514, 28178239, ...21220307
S1000 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 18669648, 15302935, ...20068231
K1009 Ubiquitination PhosphoSitePlus
T1012 Phosphorylation HPRD   PhosphoSitePlus 20068231
K1019 Ubiquitination PhosphoSitePlus
K1020 Ubiquitination PhosphoSitePlus
C1046 Methylation IEDB 31844290
K1069 Ubiquitination PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
S1083 O-Glycosylation GlyGen 23301498, 16408927, 33214551, ...35138101, 27655845, 30379171, 34725712, 26853435, 34019948, 21740066, 29351928, 35132862, 35083852, 32870666, 20305658, 32119511, 28510447, 33465208
K1091 Ubiquitination PhosphoSitePlus
K1109 Ubiquitination PhosphoSitePlus
T1121 Phosphorylation HPRD 20068231
K1132 Ubiquitination PhosphoSitePlus
K1143 Ubiquitination PhosphoSitePlus
R1152 Methylation PhosphoSitePlus   UniProt 24129315
K1156 Acetylation PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
K1207 Ubiquitination PhosphoSitePlus
Y1221 Phosphorylation PhosphoSitePlus
T1222 Phosphorylation PhosphoSitePlus
K1250 Methylation PhosphoSitePlus
R1278 Methylation PhosphoSitePlus
T1279 Phosphorylation PhosphoSitePlus
S1336 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1349 Phosphorylation PhosphoSitePlus
S1350 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1354 Methylation PhosphoSitePlus
K1361 Ubiquitination PhosphoSitePlus
K1375 Ubiquitination PhosphoSitePlus
C1377 S-Nitrosylation dbSNO 2212679, 22126794, 26338901
K1389 Acetylation PhosphoSitePlus
K1389 Ubiquitination PhosphoSitePlus
K1435 Ubiquitination PhosphoSitePlus
K1458 Ubiquitination PhosphoSitePlus
K1477 Ubiquitination PhosphoSitePlus
C1480 S-Nitrosylation dbSNO 26338901
K1484 Ubiquitination PhosphoSitePlus
C1487 S-Nitrosylation dbSNO 26338901
K1503 Acetylation PhosphoSitePlus   UniProt 19608861
K1503 Ubiquitination PhosphoSitePlus
R1510 Methylation PhosphoSitePlus


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000037787 (hEPRS/Phos:1) pS886,pS999 PRO 19647514


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 G29 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
K173 N173 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
M277 L277 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S330 N330 Biomuta DOID:3571 / liver cancer [ cosmic ]
R464 T464 Biomuta DOID:4159 / skin cancer [ cosmic ]
R464 K464 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K497 E497 Biomuta DOID:4159 / skin cancer [ cosmic ]
K497 R497 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K542 T542 Biomuta DOID:3571 / liver cancer [ cosmic ]
K581 T581 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T631 S631 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K647 N647 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y690 H690 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K708 R708 Biomuta DOID:3571 / liver cancer [ cosmic ]
K720 T720 Biomuta DOID:1324 / lung cancer [ cosmic ]
T728 I728 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S739 F739 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S750 Y750 Biomuta DOID:363 / uterine cancer [ icgc ]
S813 Y813 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S814 F814 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S825 Y825 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S825 F825 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K861 N861 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S880 C880 Biomuta DOID:1612 / breast cancer [ cosmic ]
S883 L883 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic, icgc ]
S885 * Biomuta DOID:3571 / liver cancer [ cosmic ]
S891 F891 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K925 N925 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S954 L954 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S990 F990 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S990 C990 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S999 L999 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1020 E1020 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K1020 Q1020 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C1046 W1046 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1069 M1069 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K1069 N1069 Biomuta DOID:363 / uterine cancer [ icgc ]
K1070 N1070 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
R1152 L1152 Biomuta DOID:1324 / lung cancer [ cosmic ]
R1152 C1152 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R1152 H1152 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
R1278 L1278 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R1278 Q1278 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R1278 * Biomuta DOID:263 / kidney cancer [ cosmic ]
K1477 T1477 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R1510 H1510 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R1510 C1510 Biomuta DOID:4362 / cervical cancer [ icgc ]