iPTMnet Report for P07437 (TUBB)
Protein Information
UniProt AC / UniProt ID | P07437 / TBB5_HUMAN |
Protein Name | Tubulin beta chain |
Gene Name | Name: TUBB Synonyms:TUBB5;ORFNames:OK/SW-cl.56; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P07437 |
PRO Name | tubulin beta chain (human) |
Definition | A tubulin beta chain that is encoded in the genome of human. |
Short Label | hTUBB |
Category | organism-gene |
P07437 (TUBB) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
R2 | Methylation | score1 | PhosphoSitePlus | |||
C12 | S-Nitrosylation | score0 | dbSNO | 19483679 | ||
K19 | Acetylation | score1 | PhosphoSitePlus | |||
K19 | Methylation | score1 | PhosphoSitePlus | |||
K19 | Ubiquitination | score1 | PhosphoSitePlus | |||
S25 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
T33 | Phosphorylation | score1 | PhosphoSitePlus | |||
T35 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y36 | Phosphorylation | score2 | HPRD phospho.ELM PRO PhosphoSitePlus | 15592455 | ||
S40 | Phosphorylation | score1 | PhosphoSitePlus | |||
R46 | Methylation | score1 | PhosphoSitePlus | |||
S48 | Phosphorylation | score2 | HPRD PRO PhosphoSitePlus | 19664994, 19007248, 20068231, ... | ||
Y50 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
Y51 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 20068231 | ||
T55 | Phosphorylation | score2 | HPRD PRO PhosphoSitePlus UniProt | 23186163, 19007248, 19691289 | ||
K58 | Acetylation | score2 | PRO PhosphoSitePlus UniProt | 19608861 | ||
K58 | Methylation | score1 | PhosphoSitePlus | |||
K58 | Sumoylation | score1 | PhosphoSitePlus | |||
K58 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y59 | Phosphorylation | score1 | PhosphoSitePlus | |||
T72 | Phosphorylation | score1 | PhosphoSitePlus | |||
S75 | Phosphorylation | score1 | PhosphoSitePlus | |||
S78 | Phosphorylation | score1 | PhosphoSitePlus | |||
S95 | Phosphorylation | score1 | PhosphoSitePlus | |||
K103 | Acetylation | score1 | PhosphoSitePlus | |||
K103 | Sumoylation | score1 | PhosphoSitePlus | |||
K103 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y106 | Phosphorylation | score1 | PhosphoSitePlus | |||
T107 | Phosphorylation | score1 | PhosphoSitePlus | |||
S115 | Phosphorylation | score1 | PhosphoSitePlus | |||
K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
S126 | Phosphorylation | score1 | PhosphoSitePlus | |||
T136 | Phosphorylation | score1 | PhosphoSitePlus | |||
S138 | Phosphorylation | score1 | PhosphoSitePlus | |||
T143 | Phosphorylation | score1 | PhosphoSitePlus | |||
S145 | Phosphorylation | score1 | PhosphoSitePlus | |||
T149 | Phosphorylation | score1 | PhosphoSitePlus | |||
S153 | Phosphorylation | score1 | PhosphoSitePlus | |||
K154 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y159 | Phosphorylation | score1 | PhosphoSitePlus | |||
R162 | Methylation | score1 | PhosphoSitePlus | |||
T166 | Phosphorylation | score1 | PhosphoSitePlus | |||
S168 | Phosphorylation | score1 | PhosphoSitePlus | |||
S172 | Phosphorylation | score2 | neXtProt PhosphoSitePlus UniProt | 16371510 | ||
K174 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y183 | Phosphorylation | score1 | PhosphoSitePlus | |||
T196 | Phosphorylation | score1 | PhosphoSitePlus | |||
T199 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y200 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y208 | Phosphorylation | score1 | PhosphoSitePlus | |||
K216 | Acetylation | score1 | PhosphoSitePlus | |||
K216 | Ubiquitination | score1 | PhosphoSitePlus | |||
T218 | Phosphorylation | score1 | PhosphoSitePlus | |||
T219 | Phosphorylation | score1 | PhosphoSitePlus | |||
T221 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y222 | Phosphorylation | score1 | PhosphoSitePlus | |||
S234 | Phosphorylation | score1 | PhosphoSitePlus | |||
C239 | S-Nitrosylation | score0 | dbSNO | 19483679, 25040305 | ||
K252 | Acetylation | score1 | PhosphoSitePlus | |||
K252 | Sumoylation | score1 | PhosphoSitePlus | |||
K252 | Ubiquitination | score1 | PhosphoSitePlus | |||
T274 | Phosphorylation | score1 | PhosphoSitePlus | |||
S275 | Phosphorylation | Q5TCY1 (TTBK1) | score3 | HPRD PhosphoSitePlus | 7556643 | |
R276 | Methylation | score1 | PhosphoSitePlus | |||
S278 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y281 | Phosphorylation | score1 | PhosphoSitePlus | |||
T285 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T290 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K297 | Acetylation | score1 | PhosphoSitePlus | |||
K297 | Ubiquitination | score1 | PhosphoSitePlus | |||
C303 | S-Nitrosylation | score0 | dbSNO | 25040305 | ||
Y310 | Phosphorylation | score1 | PhosphoSitePlus | |||
T312 | Phosphorylation | score1 | PhosphoSitePlus | |||
R318 | Methylation | score1 | PhosphoSitePlus | |||
S322 | Phosphorylation | score1 | PhosphoSitePlus | |||
K324 | Acetylation | score1 | PhosphoSitePlus | |||
K324 | Sumoylation | score1 | PhosphoSitePlus | |||
K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
K336 | Acetylation | score1 | PhosphoSitePlus | |||
K336 | Ubiquitination | score1 | PhosphoSitePlus | |||
S338 | Phosphorylation | score1 | PhosphoSitePlus | |||
S339 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y340 | Phosphorylation | score2 | PRO PhosphoSitePlus | |||
K350 | Sumoylation | score1 | PhosphoSitePlus | |||
K350 | Ubiquitination | score1 | PhosphoSitePlus | |||
T351 | Phosphorylation | score1 | PhosphoSitePlus | |||
K362 | Ubiquitination | score1 | PhosphoSitePlus | |||
T366 | Phosphorylation | score1 | PhosphoSitePlus | |||
S371 | Phosphorylation | score1 | PhosphoSitePlus | |||
K379 | Acetylation | score1 | PhosphoSitePlus | |||
K379 | Ubiquitination | score1 | PhosphoSitePlus | |||
S382 | Phosphorylation | score1 | PhosphoSitePlus | |||
T386 | Phosphorylation | score1 | PhosphoSitePlus | |||
K392 | Ubiquitination | score1 | PhosphoSitePlus | |||
T399 | Phosphorylation | score1 | PhosphoSitePlus | |||
T409 | Phosphorylation | score2 | IntAct | 24813628 | ||
Y422 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y425 | Phosphorylation | score1 | PhosphoSitePlus | |||
T429 | Phosphorylation | score2 | HPRD PRO PhosphoSitePlus | 19007248 |
Proteoforms
PRO ID (Short Label) | Sites | PTM Enzyme | Source | PMID | |
---|---|---|---|---|---|
PR:000036901 (hTUBB/Phos:1) | pY340 | PRO | |||
PR:000036902 (hTUBB/Phos:2) | pY340,pT429 | PRO | |||
PR:000036903 (hTUBB/AcPhos:1) | acK58 | PRO | |||
PR:000036903 (hTUBB/AcPhos:1) | pY36,pS48 | PRO | |||
PR:000036904 (hTUBB/AcPhos:2) | acK58 | PRO | |||
PR:000036904 (hTUBB/AcPhos:2) | pY36,pS48,pT55,pY340 | PRO |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P07437 (TUBB) | T409 | P25098 (GRK2) | unknown | eFIP | 24813628 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
T33 | S33 | Biomuta | DOID:5041 / esophageal cancer [ icgc ] | |
S48 | F48 | Biomuta | DOID:11054 / urinary bladder cancer [ tcga ] | |
S75 | C75 | Biomuta | DOID:4159 / skin cancer [ icgc ] | |
S115 | Y115 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S145 | F145 | Biomuta | DOID:1909 / melanoma [ tcga ] | |
T219 | A219 | Biomuta | DOID:3070 / malignant glioma [ tcga ] | |
R276 | H276 | Biomuta | DOID:11054 / urinary bladder cancer [ tcga ] | |
S339 | G339 | Biomuta | DOID:9256 / colorectal cancer [ tcga ] | |
K362 | N362 | Biomuta | DOID:3963 / thyroid carcinoma [ icgc ] |