iPTMnet Report for P07357 (C8A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07357 / CO8A_HUMAN
Protein Name Complement component C8 alpha chain precursor
Gene Name Name: C8A
Organism Homo sapiens (Human)

PRO ID PR:P07357
DAG View
PRO Name complement component C8 alpha chain (human)
Definition A complement component C8 alpha chain that is encoded in the genome of human.
Short Label hC8A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07357 (C8A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S10 Phosphorylation PhosphoSitePlus
T13 Phosphorylation PhosphoSitePlus
W44 C-Glycosylation GlyGen   UniProt 10551839
S125 Phosphorylation PhosphoSitePlus
T290 Phosphorylation HPRD   PhosphoSitePlus 19664994
Y341 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus
K359 Methylation PhosphoSitePlus
S395 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
S431 Phosphorylation PhosphoSitePlus
N437 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 29671580, ...19159218, 29741879
S439 Phosphorylation PhosphoSitePlus
Y452 Phosphorylation PhosphoSitePlus
W542 C-Glycosylation GlyGen   UniProt 10551839
W545 C-Glycosylation GlyGen   UniProt 10551839
W548 C-Glycosylation GlyGen   UniProt 10551839
Site PTM Type PTM Enzyme Score Source PMID
N437 N-Glycosylation PRO 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S10 F10 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S10 P10 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S125 C125 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S346 F346 Biomuta DOID:4159 / skin cancer [ cosmic ]
S395 L395 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S427 I427 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S428 Y428 Biomuta DOID:363 / uterine cancer [ icgc ]
N437 S437 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
W542 S542 Biomuta DOID:1324 / lung cancer [ cosmic ]