iPTMnet Report for P07339 (CTSD)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07339 / CATD_HUMAN
Protein Name Cathepsin D precursor
Gene Name Name: CTSD
Synonyms:CPSD;
Organism Homo sapiens (Human)

PRO ID PR:P07339
DAG View
PRO Name cathepsin D (human)
Definition A cathepsin D that is encoded in the genome of human.
Short Label hCTSD
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07339 (CTSD) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K28 Ubiquitination PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
T63 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 23584533, 30459171, 25813380, ...23234360
K122 Acetylation PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
N134 N-Glycosylation GlyGen   UniProt 29741879, 19159218
K184 Ubiquitination PhosphoSitePlus
N209 N-Glycosylation GlyGen 24190977
N210 N-Glycosylation GlyGen 24190977
T250 Phosphorylation PhosphoSitePlus
S252 Phosphorylation HPRD   PhosphoSitePlus 18452278
K253 Ubiquitination PhosphoSitePlus
S260 O-Glycosylation GlyGen 27655845, 33214551, 30397120, ...26374642, 34725712, 34019948, 35132862, 36240223, 22661428
N263 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 29391424, 16263699, 8393577, 29741879, 12754519
T265 O-Glycosylation GlyGen 27655845, 33214551, 30397120, ...26374642, 34725712, 34019948, 35132862, 36240223, 22661428
K313 Ubiquitination PhosphoSitePlus
Y325 Phosphorylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
T334 Phosphorylation PhosphoSitePlus
T339 Phosphorylation PhosphoSitePlus
K341 Ubiquitination PhosphoSitePlus
Y347 Phosphorylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
Y354 Phosphorylation PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S42 Y42 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K313 T313 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S333 F333 Biomuta DOID:4159 / skin cancer [ cosmic ]
K357 R357 Biomuta DOID:263 / kidney cancer [ cosmic ]