Protein Information

Cytoscape View


UniProt AC / UniProt ID P07333 / CSF1R_HUMAN
Protein Name Macrophage colony-stimulating factor 1 receptor precursor
Gene Name Name: CSF1R
Synonyms:FMS;
Organism Homo sapiens (Human)

PRO ID PR:P07333
DAG View
PRO Name macrophage colony-stimulating factor 1 receptor (human)
Definition A macrophage colony-stimulating factor 1 receptor that is encoded in the genome of human.
Short Label hCSF1R
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07333 (CSF1R) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N153 N-Glycosylation GlyGen 23090970, 29391424
S178 Phosphorylation PhosphoSitePlus
N275 N-Glycosylation GlyGen 23090970
N302 N-Glycosylation GlyGen   UniProt 16335952
N353 N-Glycosylation GlyGen   UniProt 16335952, 29391424
T363 Phosphorylation PhosphoSitePlus
T365 Phosphorylation PhosphoSitePlus
Y546 Phosphorylation P07333 (CSF1R) PhosphoSitePlus   RLIMS-P   UniProt 8798707, 24336230, 20489731, ...22974529, 30136118, 31827782
S555 Phosphorylation PhosphoSitePlus
Y556 Phosphorylation PhosphoSitePlus
S560 Phosphorylation PhosphoSitePlus
Y561 Phosphorylation P07333 (CSF1R) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15297464, 7730365, 21049007
T562 Phosphorylation PhosphoSitePlus
T567 Phosphorylation PhosphoSitePlus
Y571 Phosphorylation PhosphoSitePlus
K586 Ubiquitination PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus
S688 Phosphorylation PhosphoSitePlus
Y699 Phosphorylation P07333 (CSF1R) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19369195, 8798707, 20489731, ...21049007, 22974529, 31827782, 15297464
Y708 Phosphorylation P07333 (CSF1R) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23924795, 20489731, 29796177, ...22974529, 30136118, 15297464
S713 Phosphorylation PhosphoSitePlus   UniProt 19369195
S716 Phosphorylation PhosphoSitePlus
Y723 Phosphorylation P07333 (CSF1R) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9191055, 21266043, 24336230, ...20489731, 31033097, 29796177, 24019961, 22974529, 30136118, 15297464, 9312046, 23924795
S759 Phosphorylation PhosphoSitePlus
N805 N-Glycosylation GlyGen 29391424
Y809 Phosphorylation P07333 (CSF1R) IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24336230, 20489731, 7579387, ...22974529, 7681396, 31827782, 7526094, 15297464, 2168557
K812 Ubiquitination PhosphoSitePlus
K870 Ubiquitination PhosphoSitePlus
Y873 Phosphorylation PhosphoSitePlus
Y923 Phosphorylation PhosphoSitePlus   RLIMS-P 22974529, 21049007
Y969 Phosphorylation P07333 (CSF1R) neXtProt   Signor 11850825, 15297464
Site PTM Type PTM Enzyme Score Source PMID
Y723 Phosphorylation HPRD 9191055
Y809 Phosphorylation P07333 (CSF1R) HPRD 1833648


P07333 (CSF1R) as PTM Enzyme



Substrate Site Score Source PMID
P07333 (CSF1R) Y546 PhosphoSitePlus   UniProt 8798707, 20489731
P07333 (CSF1R) Y561 phospho.ELM   PhosphoSitePlus   Signor 15297464
P07333 (CSF1R) Y699 PhosphoSitePlus   Signor   UniProt 8798707, 20489731, 15297464
P07333 (CSF1R) Y708 Signor   UniProt 20489731, 15297464
P07333 (CSF1R) Y723 Signor   UniProt 15297464, 20489731
P07333 (CSF1R) Y809 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 7526094, 1833648, 15297464, ...20489731
P07333 (CSF1R) Y969 neXtProt   Signor 11850825, 15297464


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P07333 (CSF1R) Y561 Q04736 (Yes1) unknown eFIP 7730365
Phosphorylation P07333 (CSF1R) Y561 P05480 (Src) unknown eFIP 7730365
Phosphorylation P07333 (CSF1R) Y809 P06241 (FYN) unknown eFIP 7681396
Phosphorylation P07333 (CSF1R) Y723 Q8CIH5 (Plcg2) unknown eFIP 9312046
Phosphorylation P07333 (CSF1R) Y561 P39688 (Fyn) unknown eFIP 7730365


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N302 H302 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
T363 N363 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S560 N560 Biomuta DOID:4362 / cervical cancer [ tcga ]
Y571 * Biomuta DOID:1324 / lung cancer [ tcga ]
K812 N812 Biomuta DOID:1324 / lung cancer [ tcga ]