Protein Information

Cytoscape View

UniProt AC / UniProt ID P07305 / H10_HUMAN
Protein Name Histone H1.0
Gene Name Name: H1-0
Organism Homo sapiens (Human)

PRO ID PR:P07305
DAG View
PRO Name histone H1.0 (human)
Definition A histone H1.0 that is encoded in the genome of human.
Short Label hH1-0
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P07305 (H1-0) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
T2 Acetylation UniProt 19413330, 9582379
T2 Phosphorylation PhosphoSitePlus
S5 Phosphorylation PhosphoSitePlus
S7 Phosphorylation PhosphoSitePlus
K12 Methylation PhosphoSitePlus
K14 Acetylation PhosphoSitePlus
K27 Acetylation PhosphoSitePlus
K27 Ubiquitination PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K52 Acetylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
Y58 Phosphorylation PhosphoSitePlus
K59 Acetylation PhosphoSitePlus
K59 Methylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
S66 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K82 Methylation PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
T84 Phosphorylation PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
S90 Phosphorylation PhosphoSitePlus
S92 Phosphorylation PhosphoSitePlus
K102 Methylation PhosphoSitePlus
K108 Acetylation PhosphoSitePlus
K108 Methylation PhosphoSitePlus
T119 Phosphorylation PhosphoSitePlus
K121 Acetylation PhosphoSitePlus
S124 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T141 Phosphorylation PhosphoSitePlus
K149 Acetylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
T153 Phosphorylation PhosphoSitePlus
K155 Methylation PhosphoSitePlus
K161 Acetylation PhosphoSitePlus
S171 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T2 Phosphorylation HPRD 18491316, 19691289
S5 Phosphorylation HPRD 19007248, 17043054
S66 Phosphorylation HPRD 17525332
S124 Phosphorylation HPRD 17081983

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S5 F5 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K12 N12 Biomuta DOID:3571 / liver cancer [ icgc ]
S66 L66 Biomuta DOID:1909 / melanoma [ cosmic ] DOID:11054 / urinary bladder cancer [ tcga ]
K102 N102 Biomuta DOID:363 / uterine cancer [ tcga ]
K108 N108 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ]
K121 N121 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K149 Q149 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S171 F171 Biomuta DOID:363 / uterine cancer [ tcga ]