iPTMnet Report P07197 NEFM

Protein Information

UniProt AC / UniProt ID	P07197 / NFM_HUMAN
Protein Name	Neurofilament medium polypeptide
Gene Name	Name: NEFM Synonyms:NEF3,NFM;
Organism	Homo sapiens (Human)

PRO ID	PR:P07197 DAG View
PRO Name	neurofilament medium polypeptide (human)
Definition	A neurofilament medium polypeptide that is encoded in the genome of human.
Short Label	hNEFM
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P07197 (NEFM) as Substrate

Expanded View

Site	PTM Type	Score	Source	PMID
R21	Methylation	score1	PhosphoSitePlus
S23	Phosphorylation	score1	PhosphoSitePlus
R26	Methylation	score1	PhosphoSitePlus
S28	O-Glycosylation	score1	GlyGen	23301498, 28657654
S28	Phosphorylation	score1	PhosphoSitePlus
S30	Phosphorylation	score1	PhosphoSitePlus
S33	Phosphorylation	score1	PhosphoSitePlus
S37	Phosphorylation	score1	PhosphoSitePlus
R42	Methylation	score1	PhosphoSitePlus
S44	Phosphorylation	score1	PhosphoSitePlus
T47	O-Glycosylation	score1	GlyGen	23301498, 28657654
S49	O-Glycosylation	score1	GlyGen	23301498, 28657654
S50	O-Glycosylation	score1	GlyGen	23301498, 28657654
S51	O-Glycosylation	score1	GlyGen	23301498, 28657654
R54	Methylation	score1	PhosphoSitePlus
S55	Phosphorylation	score1	PhosphoSitePlus
S73	Phosphorylation	score1	PhosphoSitePlus
K102	Methylation	score1	PhosphoSitePlus
R111	Methylation	score1	PhosphoSitePlus
K118	Ubiquitination	score1	PhosphoSitePlus
S226	Phosphorylation	score1	PhosphoSitePlus
K259	Ubiquitination	score1	PhosphoSitePlus
K263	Ubiquitination	score1	PhosphoSitePlus
K271	Ubiquitination	score1	PhosphoSitePlus
K298	Acetylation	score1	PhosphoSitePlus
S333	Phosphorylation	score1	PhosphoSitePlus
S346	Phosphorylation	score0	RLIMS-P	28634551
R382	Methylation	score1	PhosphoSitePlus
Y384	Phosphorylation	score1	PhosphoSitePlus
Y401	Phosphorylation	score1	PhosphoSitePlus
K403	Acetylation	score1	PhosphoSitePlus
K445	Ubiquitination	score1	PhosphoSitePlus
K451	Ubiquitination	score1	PhosphoSitePlus
S467	Phosphorylation	score1	PhosphoSitePlus
S511	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340
S545	Phosphorylation	score1	PhosphoSitePlus
S553	Phosphorylation	score1	PhosphoSitePlus
S558	Phosphorylation	score1	PhosphoSitePlus
S559	Phosphorylation	score1	PhosphoSitePlus
S615	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340, 15822905
S620	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340, 15822905
S628	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	15822905
S633	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	15822905
S641	Phosphorylation	score1	PhosphoSitePlus
S646	Phosphorylation	score1	PhosphoSitePlus
K653	Acetylation	score1	PhosphoSitePlus
S654	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340
S659	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340
S667	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	15822905
S670	Phosphorylation	score1	PhosphoSitePlus
S672	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	15822905
S680	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340, 15822905
S685	Phosphorylation	score2	phospho.ELM PhosphoSitePlus	17287340, 15822905
K693	Acetylation	score1	PhosphoSitePlus
K698	Acetylation	score1	PhosphoSitePlus
S736	Phosphorylation	score4	phospho.ELM PhosphoSitePlus RLIMS-P	28634551, 17287340, 20624930
T748	Phosphorylation	score1	PhosphoSitePlus
T750	Phosphorylation	score1	PhosphoSitePlus
S783	Phosphorylation	score4	phospho.ELM PhosphoSitePlus RLIMS-P	17287340, 20624930
S788	Phosphorylation	score4	phospho.ELM PhosphoSitePlus RLIMS-P	17287340, 20624930
S821	Phosphorylation	score1	PhosphoSitePlus
S837	Phosphorylation	score4	PhosphoSitePlus RLIMS-P UniProt	21406692, 28634551, 20624930
S863	O-Glycosylation	score1	GlyGen	23301498, 28657654
K871	Ubiquitination	score1	PhosphoSitePlus
Y872	Phosphorylation	score1	PhosphoSitePlus
K875	Ubiquitination	score1	PhosphoSitePlus

Site	PTM Type	Score	Source	PMID
S511	Phosphorylation	score2	HPRD	1537832, 18510355, 17287340
S545	Phosphorylation	score2	HPRD	1537832, 18510355
S553	Phosphorylation	score0	HPRD	18510355
S558	Phosphorylation	score0	HPRD	18510355, 18452278
S559	Phosphorylation	score0	HPRD	18510355, 18452278
S615	Phosphorylation	score2	HPRD	1537832, 18510355, 17287340
S620	Phosphorylation	score2	HPRD	1537832, 18510355, 17287340
S628	Phosphorylation	score0	HPRD	18510355
S633	Phosphorylation	score0	HPRD	18510355
S641	Phosphorylation	score0	HPRD	18510355
S659	Phosphorylation	score0	HPRD	18510355
S667	Phosphorylation	score0	HPRD	18510355, 20166139
S670	Phosphorylation	score0	HPRD	18510355, 20166139
S672	Phosphorylation	score0	HPRD	18510355
S680	Phosphorylation	score0	HPRD	18510355, 17287340
S685	Phosphorylation	score0	HPRD	18510355, 17287340
S736	Phosphorylation	score2	HPRD	1537832, 18510355, 17287340, ...18452278
S783	Phosphorylation	score0	HPRD	17287340
S788	Phosphorylation	score0	HPRD	17287340
S837	Phosphorylation	score0	HPRD	18510355, 15345747

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
R21	H21	Biomuta	DOID:1909 / melanoma [ cosmic ]
S28	R28	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S30	F30	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S37	L37	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
R54	C54	Biomuta	DOID:1793 / pancreatic cancer [ icgc ]
R54	H54	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R111	C111	Biomuta	DOID:2531 / hematologic cancer [ tcga ]
R111	H111	Biomuta	DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S333	L333	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R382	C382	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R382	H382	Biomuta	DOID:1793 / pancreatic cancer [ icgc ] DOID:1909 / melanoma [ cosmic ]
Y384	C384	Biomuta	DOID:363 / uterine cancer [ tcga ]
K445	M445	Biomuta	DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
S615	Y615	Biomuta	DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S628	Y628	Biomuta	DOID:363 / uterine cancer [ tcga ] DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ] DOID:3070 / malignant glioma [ tcga ]
S659	*	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S670	P670	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
S672	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S685	L685	Biomuta	DOID:1909 / melanoma [ icgc, tcga ]
K871	R871	Biomuta	DOID:3070 / malignant glioma [ cosmic, icgc, tcga ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P07197 (NEFM)

Protein Information

Interactive Sequence View

P07197 (NEFM) as Substrate

PTM sites affected in variants