iPTMnet Report for P07197 (NEFM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07197 / NFM_HUMAN
Protein Name Neurofilament medium polypeptide
Gene Name Name: NEFM
Synonyms:NEF3,NFM;
Organism Homo sapiens (Human)

PRO ID PR:P07197
DAG View
PRO Name neurofilament medium polypeptide (human)
Definition A neurofilament medium polypeptide that is encoded in the genome of human.
Short Label hNEFM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07197 (NEFM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
R21 Methylation PhosphoSitePlus
S23 Phosphorylation PhosphoSitePlus
R26 Methylation PhosphoSitePlus
S28 O-Glycosylation GlyGen 23301498, 30379171, 28657654
S28 Phosphorylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S44 Phosphorylation PhosphoSitePlus
T47 O-Glycosylation GlyGen 23301498, 30379171, 28657654
S49 O-Glycosylation GlyGen 23301498, 30379171, 28657654
S50 O-Glycosylation GlyGen 23301498, 30379171, 28657654
S51 O-Glycosylation GlyGen 23301498, 30379171, 28657654
R54 Methylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K102 Methylation PhosphoSitePlus
R111 Methylation PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
S226 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K263 Ubiquitination PhosphoSitePlus
K271 Ubiquitination PhosphoSitePlus
K298 Acetylation PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
S346 Phosphorylation RLIMS-P 28634551
R382 Methylation PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
Y401 Phosphorylation PhosphoSitePlus
K403 Acetylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K451 Ubiquitination PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S511 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S545 Phosphorylation PhosphoSitePlus
S553 Phosphorylation PhosphoSitePlus
S558 Phosphorylation PhosphoSitePlus
S559 Phosphorylation PhosphoSitePlus
S615 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 15822905
S620 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 15822905
S628 Phosphorylation phospho.ELM   PhosphoSitePlus 15822905
S633 Phosphorylation phospho.ELM   PhosphoSitePlus 15822905
S641 Phosphorylation PhosphoSitePlus
S646 Phosphorylation PhosphoSitePlus
K653 Acetylation PhosphoSitePlus
S654 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S659 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S667 Phosphorylation phospho.ELM   PhosphoSitePlus 15822905
S670 Phosphorylation PhosphoSitePlus
S672 Phosphorylation phospho.ELM   PhosphoSitePlus 15822905
S680 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 15822905
S685 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340, 15822905
K693 Acetylation PhosphoSitePlus
K698 Acetylation PhosphoSitePlus
S736 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 28634551, 17287340
T748 Phosphorylation PhosphoSitePlus
T750 Phosphorylation PhosphoSitePlus
S783 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S788 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
S821 Phosphorylation PhosphoSitePlus
S837 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21406692, 28634551
S863 O-Glycosylation GlyGen 23301498, 30379171, 28657654
K871 Ubiquitination PhosphoSitePlus
Y872 Phosphorylation PhosphoSitePlus
K875 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S511 Phosphorylation HPRD 1537832, 18510355, 17287340
S545 Phosphorylation HPRD 1537832, 18510355
S553 Phosphorylation HPRD 18510355
S558 Phosphorylation HPRD 18510355, 18452278
S559 Phosphorylation HPRD 18510355, 18452278
S615 Phosphorylation HPRD 1537832, 18510355, 17287340
S620 Phosphorylation HPRD 1537832, 18510355, 17287340
S628 Phosphorylation HPRD 18510355
S633 Phosphorylation HPRD 18510355
S641 Phosphorylation HPRD 18510355
S659 Phosphorylation HPRD 18510355
S667 Phosphorylation HPRD 18510355, 20166139
S670 Phosphorylation HPRD 18510355, 20166139
S672 Phosphorylation HPRD 18510355
S680 Phosphorylation HPRD 18510355, 17287340
S685 Phosphorylation HPRD 18510355, 17287340
S736 Phosphorylation HPRD 1537832, 18510355, 17287340, ...18452278
S783 Phosphorylation HPRD 17287340
S788 Phosphorylation HPRD 17287340
S837 Phosphorylation HPRD 18510355, 15345747


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R21 H21 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S28 R28 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S30 F30 Biomuta DOID:1324 / lung cancer [ cosmic ]
S37 L37 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R42 C42 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
R54 H54 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
R54 C54 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3277 / thymus cancer [ cosmic ]
S73 R73 Biomuta DOID:4159 / skin cancer [ cosmic ]
R111 C111 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
R111 H111 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S333 L333 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R382 C382 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R382 H382 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
Y384 C384 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
K445 M445 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S511 A511 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S615 Y615 Biomuta DOID:4362 / cervical cancer [ cosmic ]
S628 Y628 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:1319 / brain cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
S641 Y641 Biomuta DOID:4159 / skin cancer [ cosmic ]
S659 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S667 Y667 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S670 P670 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
S672 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S685 L685 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S837 R837 Biomuta DOID:4159 / skin cancer [ cosmic ]
K871 R871 Biomuta DOID:1319 / brain cancer [ cosmic ]