iPTMnet Report for P07101 (TH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07101 / TY3H_HUMAN
Protein Name Tyrosine 3-monooxygenase
Gene Name Name: TH
Synonyms:TYH;
Organism Homo sapiens (Human)

PRO ID PR:P07101
DAG View
PRO Name tyrosine 3-monooxygenase (human)
Definition A tyrosine 3-monooxygenase that is encoded in the genome of human.
Short Label hTH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07101 (TH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T3 Phosphorylation PhosphoSitePlus
S19 Phosphorylation Q8IW41 (MAPKAPK5) , P49137 (MAPKAPK2) , Q9UQM7 (CAMK2A) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11359875, 18181650, 24947669, ...11502746, 1680128, 7901013, 16644734, 19801645, 12421349, 16626642
S40 Phosphorylation P49137 (MAPKAPK2) , P51812 (RPS6KA3) , O75582 (RPS6KA5) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 22483316, 30808844, 11359875, ...11502746, 21302933, 18406059, 18513370, 1680128, 16644734, 15287903, 1678738, 27958651, 34238765, 35013193, 18639636, 9327834, 11401575, 31035382, 18181650, 7901013, 12421349
S62 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) neXtProt   PhosphoSitePlus   Signor   UniProt 15471880, 1347949, 15447670, ...11359875, 24947669, 7901013, 16644734, 28637871
S71 Phosphorylation P49137 (MAPKAPK2) , P51812 (RPS6KA3) , Q9UQM7 (CAMK2A) , P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 11359875, 1680128, 7901013, ...16644734, 12421349
S118 Phosphorylation PhosphoSitePlus
Y230 Phosphorylation PhosphoSitePlus
Y419 Phosphorylation PhosphoSitePlus
S502 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation P49137 (MAPKAPK2) , Q13555 (CAMK2G) HPRD 7901013, 11359875, 6150037
S40 Phosphorylation P17612 (PRKACA) , P49137 (MAPKAPK2) , O75582 (RPS6KA5) HPRD 7901013, 12421349, 11359875
S62 Phosphorylation HPRD 1973163
S71 Phosphorylation HPRD 20166139
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation Q13555 (CAMK2G) , P49137 (MAPKAPK2) HPRD   PhosphoSitePlus 7901013, 11359875, 6150037
S36 Phosphorylation P17612 (PRKACA) HPRD 11359875
S58 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD   PhosphoSitePlus 16644734, 1973163, 7901013
S67 Phosphorylation P17612 (PRKACA) , P51812 (RPS6KA3) , P49137 (MAPKAPK2) HPRD   PhosphoSitePlus 1347949, 11502746, 7901013, ...20166139, 16644734, 12421349
S431 Phosphorylation HPRD 12421349
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation P49137 (MAPKAPK2) , Q8IW41 (MAPKAPK5) , Q13555 (CAMK2G) HPRD   PhosphoSitePlus 11359875, 6150037, 7901013, ...12421349, 19801645
S31 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) HPRD   PhosphoSitePlus 16644734, 12421349, 1973163, ...7901013
S40 Phosphorylation Q9UQM7 (CAMK2A) , P51812 (RPS6KA3) , P17612 (PRKACA) , O75582 (RPS6KA5) , Q8IW41 (MAPKAPK5) , P49137 (MAPKAPK2) HPRD   PhosphoSitePlus 24947669, 1347949, 11502746, ...7901013, 20166139, 16644734, 12421349
S404 Phosphorylation Q8IW41 (MAPKAPK5) , P49137 (MAPKAPK2) HPRD   PhosphoSitePlus 12421349
Site PTM Type PTM Enzyme Score Source PMID
S19 Phosphorylation Q9UQM7 (CAMK2A) , P49137 (MAPKAPK2) PhosphoSitePlus 7901013, 1680128
S35 Phosphorylation Q9UQM7 (CAMK2A) , P27361 (MAPK3) PhosphoSitePlus 7901013, 1680128
S44 Phosphorylation P51812 (RPS6KA3) , P17612 (PRKACA) , P49137 (MAPKAPK2) , Q9UQM7 (CAMK2A) PhosphoSitePlus 7901013, 16644734, 1680128


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T3 I3 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, cosmic ]
S19 C19 Biomuta DOID:10534 / stomach cancer [ cosmic ]