iPTMnet Report for P07099 (EPHX1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P07099 / HYEP_HUMAN
Protein Name Epoxide hydrolase 1
Gene Name Name: EPHX1
Synonyms:EPHX,EPOX;
Organism Homo sapiens (Human)

PRO ID PR:P07099
DAG View
PRO Name epoxide hydrolase 1 (human)
Definition An epoxide hydrolase 1 that is encoded in the genome of human.
Short Label hEPHX1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P07099 (EPHX1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
T55 Phosphorylation PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
K91 Ubiquitination PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
S95 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K105 Ubiquitination PhosphoSitePlus
K117 Methylation PhosphoSitePlus
K119 Methylation PhosphoSitePlus
K131 Acetylation PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
S173 Phosphorylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
T204 Phosphorylation PhosphoSitePlus
K210 Acetylation PhosphoSitePlus
Y283 Phosphorylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
Y291 Phosphorylation PhosphoSitePlus
S297 Phosphorylation PhosphoSitePlus
Y299 Phosphorylation PhosphoSitePlus
Y339 Phosphorylation PhosphoSitePlus
Y361 Phosphorylation PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
Y393 Phosphorylation PhosphoSitePlus
T408 Phosphorylation PhosphoSitePlus
S422 Phosphorylation HPRD 20068231
Y423 Phosphorylation PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus
S450 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 I47 Biomuta DOID:363 / uterine cancer [ icgc ]
S56 A56 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K197 T197 Biomuta DOID:3571 / liver cancer [ cosmic ]
K210 R210 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
Y283 N283 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y291 H291 Biomuta DOID:263 / kidney cancer [ icgc ]
Y339 C339 Biomuta DOID:3571 / liver cancer [ cosmic ]
T408 K408 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T408 M408 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]
Y423 N423 Biomuta DOID:4159 / skin cancer [ cosmic ]