Protein Information

Cytoscape View

UniProt AC / UniProt ID P06865 / HEXA_HUMAN
Protein Name Beta-hexosaminidase subunit alpha precursor
Gene Name Name: HEXA
Organism Homo sapiens (Human)

PRO ID PR:P06865
DAG View
PRO Name beta-hexosaminidase subunit alpha (human)
Definition A beta-hexosaminidase subunit alpha that is encoded in the genome of human.
Short Label hHEXA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P06865 (HEXA) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
N115 N-Glycosylation GlyGen   UniProt 16698036, 11707436, 1533633
N157 N-Glycosylation GlyGen   UniProt 19159218, 24190977, 16698036, ...11707436, 1533633, 29741879
T189 Phosphorylation PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
Y227 O-Glycosylation GlyGen 23584533, 25813380
N295 N-Glycosylation GlyGen   UniProt 16698036, 11707436, 19159218, ...1533633
S331 Phosphorylation PhosphoSitePlus
K342 Ubiquitination PhosphoSitePlus
S417 Phosphorylation PhosphoSitePlus
Y421 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T21 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T21 M21 Biomuta DOID:363 / uterine cancer [ tcga ]
N295 S295 Biomuta DOID:2394 / ovarian cancer [ tcga ] DOID:2994 / germ cell cancer [ cosmic ]
K342 R342 Biomuta DOID:2994 / germ cell cancer [ cosmic ]